7B36

MST4 in complex with compound G-5555

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004672	molecular_function	protein kinase activity
A	0005524	molecular_function	ATP binding
A	0006468	biological_process	protein phosphorylation
C	0004672	molecular_function	protein kinase activity
C	0005524	molecular_function	ATP binding
C	0006468	biological_process	protein phosphorylation

Functional Information from PDB Data

site_id	AC1
Number of Residues	2
Details	binding site for residue EDO A 701

Chain	Residue
A	LYS40
A	HOH809

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site_id	AC2
Number of Residues	2
Details	binding site for residue EDO A 702

Chain	Residue
A	PHE184
A	SER220

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site_id	AC3
Number of Residues	15
Details	binding site for residue 59T A 703

Chain	Residue
A	LEU74
A	MET99
A	GLU100
A	LEU102
A	ALA148
A	ASN149
A	LEU151
A	ASP162
A	HOH817
A	HOH829
A	VAL38
A	ALA51
A	LYS53
A	GLU70
A	ILE71

---

site_id	AC4
Number of Residues	4
Details	binding site for residue CL A 704

Chain	Residue
A	LEU110
A	LEU287
A	ARG290
A	PHE291

---

site_id	AC5
Number of Residues	4
Details	binding site for residue EDO C 501

Chain	Residue
C	PHE184
C	PRO217
C	SER220
C	HOH602

---

site_id	AC6
Number of Residues	15
Details	binding site for residue 59T C 502

Chain	Residue
C	VAL38
C	ALA51
C	LYS53
C	ILE71
C	LEU74
C	ILE97
C	MET99
C	GLU100
C	LEU102
C	ALA148
C	ASN149
C	LEU151
C	ASP162
C	HOH606
C	HOH613

---

Functional Information from PROSITE/UniProt

site_id	PS00107
Number of Residues	24
Details	PROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. IGKGSFGEVFkGidnrtqqv..........VAIK

Chain	Residue	Details
A	ILE30-LYS53

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	ACT_SITE: Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU00159

Chain	Residue	Details
A	ASP144
C	ASP144

---

site_id	SWS_FT_FI2
Number of Residues	2
Details	BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00159

Chain	Residue	Details
C	ILE30
A	ILE30

---

site_id	SWS_FT_FI3
Number of Residues	2
Details	BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000305|PubMed:29232556

Chain	Residue	Details
C	LYS53
A	LYS53

---

site_id	SWS_FT_FI4
Number of Residues	2
Details	MOD_RES: N-acetylalanine => ECO:0007744|PubMed:19369195, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:21406692

Chain	Residue	Details
C	ALA2
A	ALA2

---

site_id	SWS_FT_FI5
Number of Residues	2
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:18691976, ECO:0007744|PubMed:19369195, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:21406692, ECO:0007744|PubMed:23186163

Chain	Residue	Details
A	SER4
C	SER4

---

site_id	SWS_FT_FI6
Number of Residues	2
Details	MOD_RES: Phosphothreonine; by autocatalysis => ECO:0000269|PubMed:15037601, ECO:0007744|PubMed:18691976, ECO:0007744|PubMed:19369195, ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:23186163

Chain	Residue	Details
C	THR178
A	THR178

---

site_id	SWS_FT_FI7
Number of Residues	2
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:19369195, ECO:0007744|PubMed:21406692

Chain	Residue	Details
A	SER300
C	SER300

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