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7AXR

Crystal structure of BRD4(1) bound to the dual BET-HDAC inhibitor LSH24

Functional Information from PDB Data
site_idAC1
Number of Residues17
Detailsbinding site for residue S7T A 201
ChainResidue
ATHR73
AGLU154
ALEU156
AGLN159
ALYS160
AHOH342
AHOH354
AHOH356
AHOH366
AGLN78
AASN130
ATHR134
ATYR137
APRO142
AGLY143
AVAL147
AGLU151

site_idAC2
Number of Residues14
Detailsbinding site for residue S7T A 202
ChainResidue
ATRP81
APRO82
AGLN85
AVAL87
AASP96
ATYR97
ATYR139
AASN140
AILE146
AHOH306
AHOH315
AHOH362
AHOH373
AHOH386

Functional Information from PROSITE/UniProt
site_idPS00633
Number of Residues60
DetailsBROMODOMAIN_1 Bromodomain signature. AwpFqqpvDavklnlpDYYkiIktpMdmgtIkkrlenny..Ywnaqeciqdfnt.MftNCyiY
ChainResidueDetails
AALA80-TYR139

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues1
DetailsSITE: Acetylated histone binding => ECO:0000269|PubMed:22464331
ChainResidueDetails
AASN140

site_idSWS_FT_FI2
Number of Residues2
DetailsCROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:28112733
ChainResidueDetails
ALYS99

222624

PDB entries from 2024-07-17

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