Loading
PDBj
MenuPDBj@FacebookPDBj@X(formerly Twitter)PDBj@BlueSkyPDBj@YouTubewwPDB FoundationwwPDBDonate
RCSB PDBPDBeBMRBAdv. SearchSearch help

7AXR

Crystal structure of BRD4(1) bound to the dual BET-HDAC inhibitor LSH24

Functional Information from PDB Data
site_idAC1
Number of Residues17
Detailsbinding site for residue S7T A 201
ChainResidue
ATHR73
AGLU154
ALEU156
AGLN159
ALYS160
AHOH342
AHOH354
AHOH356
AHOH366
AGLN78
AASN130
ATHR134
ATYR137
APRO142
AGLY143
AVAL147
AGLU151

site_idAC2
Number of Residues14
Detailsbinding site for residue S7T A 202
ChainResidue
ATRP81
APRO82
AGLN85
AVAL87
AASP96
ATYR97
ATYR139
AASN140
AILE146
AHOH306
AHOH315
AHOH362
AHOH373
AHOH386

Functional Information from PROSITE/UniProt
site_idPS00633
Number of Residues60
DetailsBROMODOMAIN_1 Bromodomain signature. AwpFqqpvDavklnlpDYYkiIktpMdmgtIkkrlenny..Ywnaqeciqdfnt.MftNCyiY
ChainResidueDetails
AALA80-TYR139

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues106
DetailsDomain: {"description":"Bromo 1","evidences":[{"source":"PROSITE-ProRule","id":"PRU00035","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

site_idSWS_FT_FI2
Number of Residues1
DetailsSite: {"description":"Acetylated histone binding","evidences":[{"source":"PubMed","id":"22464331","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails

site_idSWS_FT_FI3
Number of Residues2
DetailsCross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)","evidences":[{"source":"PubMed","id":"28112733","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

242842

PDB entries from 2025-10-08

PDB statisticsPDBj update infoContact PDBjnumon