7AXD

Crystal structure of the hPXR-LBD in complex with fipronil

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003677	molecular_function	DNA binding
A	0004879	molecular_function	nuclear receptor activity
A	0006355	biological_process	regulation of DNA-templated transcription

Functional Information from PDB Data

site_id	AC1
Number of Residues	14
Details	binding site for residue S6W A 501

Chain	Residue
A	MET243
A	TYR306
A	MET323
A	HIS407
A	IPA504
A	IPA505
A	MET246
A	SER247
A	PHE251
A	PHE281
A	CYS284
A	GLN285
A	PHE288
A	TRP299

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site_id	AC2
Number of Residues	1
Details	binding site for residue IPA A 502

Chain	Residue
A	TRP223

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site_id	AC3
Number of Residues	1
Details	binding site for residue IPA A 504

Chain	Residue
A	S6W501

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site_id	AC4
Number of Residues	4
Details	binding site for residue IPA A 505

Chain	Residue
A	LEU209
A	MET243
A	MET323
A	S6W501

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site_id	AC5
Number of Residues	6
Details	binding site for residue IPA A 506

Chain	Residue
A	LEU335
A	GLU337
A	TYR340
A	ARG387
A	HOH604
A	HOH623

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	5
Details	Binding site: {"evidences":[{"source":"PubMed","id":"12578355","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1M13","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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