7AVD
Structure of SARS-CoV-2 Main Protease bound to SEN1269 ligand
Functional Information from GO Data
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 6 |
| Details | binding site for residue CL A 401 |
| Chain | Residue |
| A | PHE8 |
| A | THR111 |
| A | GLN127 |
| A | ASN151 |
| A | ASP295 |
| A | ARG298 |
| site_id | AC2 |
| Number of Residues | 10 |
| Details | binding site for residue S1W B 401 |
| Chain | Residue |
| B | ASP187 |
| B | GLN189 |
| B | ILE249 |
| B | PRO252 |
| B | VAL297 |
| B | PHE305 |
| B | GLN306 |
| B | CYS44 |
| B | MET49 |
| B | HIS164 |
| site_id | AC3 |
| Number of Residues | 4 |
| Details | binding site for residue CL B 402 |
| Chain | Residue |
| B | THR111 |
| B | GLN127 |
| B | ASN151 |
| B | ASP295 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 610 |
| Details | Domain: {"description":"Peptidase C30","evidences":[{"source":"PROSITE-ProRule","id":"PRU00772","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | Active site: {"description":"For 3CL-PRO activity","evidences":[{"source":"PROSITE-ProRule","id":"PRU00772","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"32198291","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | Active site: {"description":"Nucleophile; for 3CL-PRO activity","evidences":[{"source":"PROSITE-ProRule","id":"PRU00772","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"32198291","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 6 |
| Details | Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)","evidences":[{"source":"PubMed","id":"39223933","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
