7AU3
Cytochrome c oxidase structure in F-state
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004129 | molecular_function | cytochrome-c oxidase activity |
| A | 0005886 | cellular_component | plasma membrane |
| A | 0006119 | biological_process | oxidative phosphorylation |
| A | 0006811 | biological_process | monoatomic ion transport |
| A | 0009060 | biological_process | aerobic respiration |
| A | 0015990 | biological_process | electron transport coupled proton transport |
| A | 0016020 | cellular_component | membrane |
| A | 0020037 | molecular_function | heme binding |
| A | 0045277 | cellular_component | respiratory chain complex IV |
| A | 0046872 | molecular_function | metal ion binding |
| A | 0070469 | cellular_component | respirasome |
| A | 1902600 | biological_process | proton transmembrane transport |
| B | 0004129 | molecular_function | cytochrome-c oxidase activity |
| B | 0005507 | molecular_function | copper ion binding |
| B | 0016020 | cellular_component | membrane |
| B | 0016491 | molecular_function | oxidoreductase activity |
| B | 0022900 | biological_process | electron transport chain |
| C | 0004129 | molecular_function | cytochrome-c oxidase activity |
| C | 0005886 | cellular_component | plasma membrane |
| C | 0009055 | molecular_function | electron transfer activity |
| C | 0016020 | cellular_component | membrane |
| C | 0019646 | biological_process | aerobic electron transport chain |
| C | 0022904 | biological_process | respiratory electron transport chain |
| C | 1902600 | biological_process | proton transmembrane transport |
| D | 0004129 | molecular_function | cytochrome-c oxidase activity |
| D | 0005886 | cellular_component | plasma membrane |
| D | 0016020 | cellular_component | membrane |
| D | 1902600 | biological_process | proton transmembrane transport |
Functional Information from PROSITE/UniProt
| site_id | PS00077 |
| Number of Residues | 55 |
| Details | COX1_CUB Heme-copper oxidase catalytic subunit, copper B binding region signature. WFFGHPeVyiiilpgfgiishvistfakkpifgylpmvlamaaigilgfvvwa..HH |
| Chain | Residue | Details |
| A | TRP272-HIS326 |
| site_id | PS00078 |
| Number of Residues | 49 |
| Details | COX2 CO II and nitrous oxide reductase dinuclear copper centers signature. ViHawtipafavkqdavpgriaqlwfsvdqegvyfgq......CselCginHayM |
| Chain | Residue | Details |
| B | VAL179-MET227 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 21 |
| Details | TOPO_DOM: Cytoplasmic |
| Chain | Residue | Details |
| C | ALA1-SER14 | |
| C | GLU77-HIS78 | |
| C | GLY166-ASP167 | |
| C | GLY237-GLN243 | |
| A | GLY365-PHE369 | |
| A | ARG438-TYR440 | |
| A | LYS515-HIS558 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 199 |
| Details | TRANSMEM: Helical |
| Chain | Residue | Details |
| C | ILE15-MET35 | |
| C | PRO48-GLY76 | |
| C | THR79-TYR114 | |
| C | HIS139-GLU165 | |
| C | ARG168-ALA196 | |
| C | THR203-LYS236 | |
| C | HIS244-ARG273 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 39 |
| Details | TOPO_DOM: Periplasmic |
| Chain | Residue | Details |
| C | LYS36-GLY47 | |
| C | PRO115-TRP138 | |
| C | ALA197-ASP202 | |
| A | MET332 | |
| A | ALA396-ASP404 | |
| A | GLY470-TYR478 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 6 |
| Details | BINDING: |
| Chain | Residue | Details |
| B | HIS181 | |
| B | CYS216 | |
| B | GLU218 | |
| B | CYS220 | |
| B | HIS224 | |
| B | MET227 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 1 |
| Details | MOD_RES: Pyrrolidone carboxylic acid => ECO:0000269|PubMed:2820725 |
| Chain | Residue | Details |
| B | GLN1 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 29 |
| Details | TRANSMEM: Helical; Name=IV |
| Chain | Residue | Details |
| A | TYR177-ASN206 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 33 |
| Details | TRANSMEM: Helical; Name=V |
| Chain | Residue | Details |
| A | PRO218-PHE251 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 36 |
| Details | TRANSMEM: Helical; Name=VI |
| Chain | Residue | Details |
| A | ASP263-LYS299 |
| site_id | SWS_FT_FI9 |
| Number of Residues | 27 |
| Details | TRANSMEM: Helical; Name=VII |
| Chain | Residue | Details |
| A | GLY304-GLY331 |
| site_id | SWS_FT_FI10 |
| Number of Residues | 31 |
| Details | TRANSMEM: Helical; Name=VIII |
| Chain | Residue | Details |
| A | SER333-GLY364 |
| site_id | SWS_FT_FI11 |
| Number of Residues | 25 |
| Details | TRANSMEM: Helical; Name=IX |
| Chain | Residue | Details |
| A | LYS370-GLN395 |
| site_id | SWS_FT_FI12 |
| Number of Residues | 32 |
| Details | TRANSMEM: Helical; Name=X |
| Chain | Residue | Details |
| A | THR405-GLY437 |
| site_id | SWS_FT_FI13 |
| Number of Residues | 28 |
| Details | TRANSMEM: Helical; Name=XI |
| Chain | Residue | Details |
| A | PRO441-GLN469 |
| site_id | SWS_FT_FI14 |
| Number of Residues | 35 |
| Details | TRANSMEM: Helical; Name=XII |
| Chain | Residue | Details |
| A | PRO479-GLY514 |
| site_id | SWS_FT_FI15 |
| Number of Residues | 3 |
| Details | BINDING: axial binding residue |
| Chain | Residue | Details |
| A | HIS94 | |
| A | HIS411 | |
| A | HIS413 |
| site_id | SWS_FT_FI16 |
| Number of Residues | 4 |
| Details | BINDING: |
| Chain | Residue | Details |
| A | HIS276 | |
| A | TYR280 | |
| A | HIS325 | |
| A | HIS326 |
| site_id | SWS_FT_FI17 |
| Number of Residues | 2 |
| Details | CROSSLNK: 1'-histidyl-3'-tyrosine (His-Tyr) |
| Chain | Residue | Details |
| A | HIS276 | |
| A | TYR280 |
