7ATU
The LIMK1 Kinase Domain Bound To LIJTF500025
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004672 | molecular_function | protein kinase activity |
| A | 0005524 | molecular_function | ATP binding |
| A | 0006468 | biological_process | protein phosphorylation |
| B | 0004672 | molecular_function | protein kinase activity |
| B | 0005524 | molecular_function | ATP binding |
| B | 0006468 | biological_process | protein phosphorylation |
| C | 0004672 | molecular_function | protein kinase activity |
| C | 0005524 | molecular_function | ATP binding |
| C | 0006468 | biological_process | protein phosphorylation |
| D | 0004672 | molecular_function | protein kinase activity |
| D | 0005524 | molecular_function | ATP binding |
| D | 0006468 | biological_process | protein phosphorylation |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 14 |
| Details | binding site for residue RXN A 701 |
| Chain | Residue |
| A | PHE350 |
| A | THR413 |
| A | LEU451 |
| A | HIS458 |
| A | ASP478 |
| A | PHE479 |
| A | ALA353 |
| A | VAL366 |
| A | LYS368 |
| A | MET388 |
| A | VAL396 |
| A | LEU397 |
| A | PHE399 |
| A | PHE411 |
| site_id | AC2 |
| Number of Residues | 14 |
| Details | binding site for residue RXN B 701 |
| Chain | Residue |
| B | ALA353 |
| B | VAL366 |
| B | LYS368 |
| B | MET388 |
| B | LEU391 |
| B | VAL396 |
| B | LEU397 |
| B | PHE399 |
| B | PHE411 |
| B | THR413 |
| B | LEU451 |
| B | HIS458 |
| B | ASP478 |
| B | PHE479 |
| site_id | AC3 |
| Number of Residues | 16 |
| Details | binding site for residue RXN C 701 |
| Chain | Residue |
| C | ALA353 |
| C | VAL366 |
| C | LYS368 |
| C | MET388 |
| C | LEU391 |
| C | VAL396 |
| C | LEU397 |
| C | PHE399 |
| C | PHE411 |
| C | THR413 |
| C | LEU451 |
| C | ILE456 |
| C | ALA477 |
| C | ASP478 |
| C | PHE479 |
| C | ARG483 |
| site_id | AC4 |
| Number of Residues | 12 |
| Details | binding site for residue RXN D 701 |
| Chain | Residue |
| D | LYS368 |
| D | MET388 |
| D | VAL396 |
| D | LEU397 |
| D | PHE399 |
| D | PHE411 |
| D | THR413 |
| D | LEU451 |
| D | HIS458 |
| D | ASP478 |
| D | PHE479 |
| D | LEU481 |
Functional Information from PROSITE/UniProt
| site_id | PS00107 |
| Number of Residues | 24 |
| Details | PROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. LGKGCFGQAIkVthretgev..........MVMK |
| Chain | Residue | Details |
| A | LEU345-LYS368 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 4 |
| Details | Active site: {"evidences":[{"evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 20 |
| Details | Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00159","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"Phosphothreonine; by ROCK1 and PAK1","evidences":[{"source":"PubMed","id":"10559936","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"10652353","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15660133","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"23633677","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"18691976","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
