7ARC

Cryo-EM structure of Polytomella Complex-I (peripheral arm)

Functional Information from GO Data

Chain	GOid	namespace	contents
B	0005739	cellular_component	mitochondrion
B	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
B	0009060	biological_process	aerobic respiration
B	0015990	biological_process	electron transport coupled proton transport
B	0032981	biological_process	mitochondrial respiratory chain complex I assembly
B	0046872	molecular_function	metal ion binding
B	0048038	molecular_function	quinone binding
B	0051536	molecular_function	iron-sulfur cluster binding
B	0051539	molecular_function	4 iron, 4 sulfur cluster binding
C	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
C	0016651	molecular_function	oxidoreductase activity, acting on NAD(P)H
D	0016651	molecular_function	oxidoreductase activity, acting on NAD(P)H
D	0048038	molecular_function	quinone binding
D	0051287	molecular_function	NAD binding
E	0016491	molecular_function	oxidoreductase activity
F	0005739	cellular_component	mitochondrion
F	0005743	cellular_component	mitochondrial inner membrane
F	0006120	biological_process	mitochondrial electron transport, NADH to ubiquinone
F	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
F	0010181	molecular_function	FMN binding
F	0045271	cellular_component	respiratory chain complex I
F	0046872	molecular_function	metal ion binding
F	0051287	molecular_function	NAD binding
F	0051539	molecular_function	4 iron, 4 sulfur cluster binding
F	1902600	biological_process	proton transmembrane transport
G	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
G	0016020	cellular_component	membrane
G	0016491	molecular_function	oxidoreductase activity
G	0016651	molecular_function	oxidoreductase activity, acting on NAD(P)H
G	0042773	biological_process	ATP synthesis coupled electron transport
G	0051536	molecular_function	iron-sulfur cluster binding
I	0003954	molecular_function	NADH dehydrogenase activity
I	0005739	cellular_component	mitochondrion
I	0006120	biological_process	mitochondrial electron transport, NADH to ubiquinone
I	0016020	cellular_component	membrane
I	0016651	molecular_function	oxidoreductase activity, acting on NAD(P)H
I	0032981	biological_process	mitochondrial respiratory chain complex I assembly
I	0051539	molecular_function	4 iron, 4 sulfur cluster binding
q	0016020	cellular_component	membrane
q	0032981	biological_process	mitochondrial respiratory chain complex I assembly
Q	0022900	biological_process	electron transport chain
U	0000035	molecular_function	acyl binding
U	0000036	molecular_function	acyl carrier activity
U	0005739	cellular_component	mitochondrion
U	0006633	biological_process	fatty acid biosynthetic process
U	1902494	cellular_component	catalytic complex
V	0022904	biological_process	respiratory electron transport chain
W	0005739	cellular_component	mitochondrion
W	0005743	cellular_component	mitochondrial inner membrane
W	0006979	biological_process	response to oxidative stress

Functional Information from PROSITE/UniProt

site_id	PS00198
Number of Residues	12
Details	4FE4S_FER_1 4Fe-4S ferredoxin-type iron-sulfur binding region signature. CiSCKlCEaICP

Chain	Residue	Details
I	CYS130-PRO141
I	CYS169-PRO180

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site_id	PS00535
Number of Residues	12
Details	COMPLEX1_49K Respiratory chain NADH dehydrogenase 49 Kd subunit signature. LHRGtEKLlEyK

Chain	Residue	Details
D	LEU48-LYS59

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site_id	PS00542
Number of Residues	22
Details	COMPLEX1_30K Respiratory chain NADH dehydrogenase 30 Kd subunit signature. EREtwDMFgvffsnHpdlRrVL

Chain	Residue	Details
C	GLU140-LEU161

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site_id	PS00641
Number of Residues	18
Details	COMPLEX1_75K_1 Respiratory-chain NADH dehydrogenase 75 Kd subunit signature 1. PrfCYhqrlsiaGnCRmC

Chain	Residue	Details
G	PRO73-CYS90

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site_id	PS00642
Number of Residues	13
Details	COMPLEX1_75K_2 Respiratory-chain NADH dehydrogenase 75 Kd subunit signature 2. CPiCDqGGeCdLQ

Chain	Residue	Details
G	CYS140-GLN152

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site_id	PS00643
Number of Residues	11
Details	COMPLEX1_75K_3 Respiratory-chain NADH dehydrogenase 75 Kd subunit signature 3. RCIhCtRCVrF

Chain	Residue	Details
G	ARG187-PHE197

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site_id	PS00644
Number of Residues	16
Details	COMPLEX1_51K_1 Respiratory-chain NADH dehydrogenase 51 Kd subunit signature 1. GAGAYICGEETALIES

Chain	Residue	Details
F	GLY208-SER223

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site_id	PS00645
Number of Residues	12
Details	COMPLEX1_51K_2 Respiratory-chain NADH dehydrogenase 51 Kd subunit signature 2. ESCGqCtPCReG

Chain	Residue	Details
F	GLU385-GLY396

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site_id	PS01099
Number of Residues	19
Details	COMPLEX1_24K Respiratory-chain NADH dehydrogenase 24 Kd subunit signature. DgtFTlgemeCMGaCvnAP

Chain	Residue	Details
E	ASP174-PRO192

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site_id	PS01150
Number of Residues	17
Details	COMPLEX1_20K Respiratory-chain NADH dehydrogenase 20 Kd subunit signature. GcDRVVPVDVYvPgCPP

Chain	Residue	Details
B	GLY120-PRO136

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