Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

7AQR

Cryo-EM structure of Arabidopsis thaliana Complex-I (peripheral arm)

Functional Information from GO Data

Chain	GOid	namespace	contents
B	0005739	cellular_component	mitochondrion
B	0005747	cellular_component	obsolete mitochondrial respiratory chain complex I
B	0005886	cellular_component	plasma membrane
B	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
B	0008270	molecular_function	zinc ion binding
B	0016491	molecular_function	oxidoreductase activity
B	0046872	molecular_function	metal ion binding
B	0048038	molecular_function	quinone binding
B	0051536	molecular_function	iron-sulfur cluster binding
B	0051539	molecular_function	4 iron, 4 sulfur cluster binding
B	0070469	cellular_component	respirasome
B	1902600	biological_process	proton transmembrane transport
C	0005739	cellular_component	mitochondrion
C	0005743	cellular_component	mitochondrial inner membrane
C	0005747	cellular_component	obsolete mitochondrial respiratory chain complex I
C	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
C	0016491	molecular_function	oxidoreductase activity
C	0016651	molecular_function	oxidoreductase activity, acting on NAD(P)H
C	0070469	cellular_component	respirasome
C	1902600	biological_process	proton transmembrane transport
D	0005739	cellular_component	mitochondrion
D	0005747	cellular_component	obsolete mitochondrial respiratory chain complex I
D	0006120	biological_process	mitochondrial electron transport, NADH to ubiquinone
D	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
D	0016491	molecular_function	oxidoreductase activity
D	0016651	molecular_function	oxidoreductase activity, acting on NAD(P)H
D	0048038	molecular_function	quinone binding
D	0051287	molecular_function	NAD binding
D	0070469	cellular_component	respirasome
D	1902600	biological_process	proton transmembrane transport
E	0005739	cellular_component	mitochondrion
E	0005743	cellular_component	mitochondrial inner membrane
E	0005747	cellular_component	obsolete mitochondrial respiratory chain complex I
E	0005829	cellular_component	cytosol
E	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
E	0008270	molecular_function	zinc ion binding
E	0016491	molecular_function	oxidoreductase activity
E	0045271	cellular_component	respiratory chain complex I
E	0046872	molecular_function	metal ion binding
E	0051537	molecular_function	2 iron, 2 sulfur cluster binding
E	0070469	cellular_component	respirasome
E	1902600	biological_process	proton transmembrane transport
F	0005739	cellular_component	mitochondrion
F	0005743	cellular_component	mitochondrial inner membrane
F	0005747	cellular_component	obsolete mitochondrial respiratory chain complex I
F	0005886	cellular_component	plasma membrane
F	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
F	0010181	molecular_function	FMN binding
F	0016491	molecular_function	oxidoreductase activity
F	0045271	cellular_component	respiratory chain complex I
F	0046872	molecular_function	metal ion binding
F	0051287	molecular_function	NAD binding
F	0051539	molecular_function	4 iron, 4 sulfur cluster binding
F	0070469	cellular_component	respirasome
F	1902600	biological_process	proton transmembrane transport
G	0005739	cellular_component	mitochondrion
G	0005743	cellular_component	mitochondrial inner membrane
G	0005747	cellular_component	obsolete mitochondrial respiratory chain complex I
G	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
G	0009507	cellular_component	chloroplast
G	0009536	cellular_component	plastid
G	0009853	biological_process	photorespiration
G	0016020	cellular_component	membrane
G	0016491	molecular_function	oxidoreductase activity
G	0016651	molecular_function	oxidoreductase activity, acting on NAD(P)H
G	0031966	cellular_component	mitochondrial membrane
G	0042773	biological_process	ATP synthesis coupled electron transport
G	0045271	cellular_component	respiratory chain complex I
G	0046872	molecular_function	metal ion binding
G	0051536	molecular_function	iron-sulfur cluster binding
G	0051537	molecular_function	2 iron, 2 sulfur cluster binding
G	0051539	molecular_function	4 iron, 4 sulfur cluster binding
G	0070469	cellular_component	respirasome
G	1902600	biological_process	proton transmembrane transport
I	0005739	cellular_component	mitochondrion
I	0005747	cellular_component	obsolete mitochondrial respiratory chain complex I
I	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
I	0016020	cellular_component	membrane
I	0016491	molecular_function	oxidoreductase activity
I	0016651	molecular_function	oxidoreductase activity, acting on NAD(P)H
I	0046872	molecular_function	metal ion binding
I	0051539	molecular_function	4 iron, 4 sulfur cluster binding
I	0070469	cellular_component	respirasome
I	1902600	biological_process	proton transmembrane transport
P	0005739	cellular_component	mitochondrion
P	0005747	cellular_component	obsolete mitochondrial respiratory chain complex I
P	0005759	cellular_component	mitochondrial matrix
P	0070469	cellular_component	respirasome
q	0005739	cellular_component	mitochondrion
q	0005743	cellular_component	mitochondrial inner membrane
q	0005747	cellular_component	obsolete mitochondrial respiratory chain complex I
q	0005829	cellular_component	cytosol
q	0016020	cellular_component	membrane
q	0032981	biological_process	mitochondrial respiratory chain complex I assembly
q	0050897	molecular_function	cobalt ion binding
q	0070469	cellular_component	respirasome
Q	0005739	cellular_component	mitochondrion
Q	0005743	cellular_component	mitochondrial inner membrane
Q	0005747	cellular_component	obsolete mitochondrial respiratory chain complex I
Q	0006970	biological_process	response to osmotic stress
Q	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
Q	0009536	cellular_component	plastid
Q	0009631	biological_process	cold acclimation
Q	0022900	biological_process	electron transport chain
Q	0050897	molecular_function	cobalt ion binding
Q	0070469	cellular_component	respirasome
Q	1902600	biological_process	proton transmembrane transport
r	0005739	cellular_component	mitochondrion
r	0005886	cellular_component	plasma membrane
R	0005739	cellular_component	mitochondrion
R	0005743	cellular_component	mitochondrial inner membrane
R	0005747	cellular_component	obsolete mitochondrial respiratory chain complex I
R	0006120	biological_process	mitochondrial electron transport, NADH to ubiquinone
R	0070469	cellular_component	respirasome
S	0005739	cellular_component	mitochondrion
S	0005743	cellular_component	mitochondrial inner membrane
S	0005747	cellular_component	obsolete mitochondrial respiratory chain complex I
S	0009536	cellular_component	plastid
S	0070469	cellular_component	respirasome
U	0000036	molecular_function	acyl carrier activity
U	0005515	molecular_function	protein binding
U	0005634	cellular_component	nucleus
U	0005739	cellular_component	mitochondrion
U	0005747	cellular_component	obsolete mitochondrial respiratory chain complex I
U	0005759	cellular_component	mitochondrial matrix
U	0005829	cellular_component	cytosol
U	0006120	biological_process	mitochondrial electron transport, NADH to ubiquinone
U	0006633	biological_process	fatty acid biosynthetic process
U	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
U	0046872	molecular_function	metal ion binding
U	0050897	molecular_function	cobalt ion binding
U	0070469	cellular_component	respirasome
U	1902600	biological_process	proton transmembrane transport
V	0005515	molecular_function	protein binding
V	0005739	cellular_component	mitochondrion
V	0005743	cellular_component	mitochondrial inner membrane
V	0005747	cellular_component	obsolete mitochondrial respiratory chain complex I
V	0009536	cellular_component	plastid
V	0009853	biological_process	photorespiration
V	0022904	biological_process	respiratory electron transport chain
V	0031966	cellular_component	mitochondrial membrane
V	0045271	cellular_component	respiratory chain complex I
V	0070469	cellular_component	respirasome
W	0005739	cellular_component	mitochondrion
W	0005743	cellular_component	mitochondrial inner membrane
W	0005747	cellular_component	obsolete mitochondrial respiratory chain complex I
W	0005829	cellular_component	cytosol
W	0070469	cellular_component	respirasome
Z	0005576	cellular_component	extracellular region
Z	0005739	cellular_component	mitochondrion
Z	0005743	cellular_component	mitochondrial inner membrane
Z	0005747	cellular_component	obsolete mitochondrial respiratory chain complex I
Z	0009793	biological_process	embryo development ending in seed dormancy
Z	0009853	biological_process	photorespiration
Z	0031966	cellular_component	mitochondrial membrane
Z	0045271	cellular_component	respiratory chain complex I
Z	0070469	cellular_component	respirasome

Functional Information from PROSITE/UniProt

site_id	PS00012
Number of Residues	16
Details	PHOSPHOPANTETHEINE Phosphopantetheine attachment site. DLGLDSLDSVEVVMAL

Chain	Residue	Details
U	ASP78-LEU93

site_id	PS00198
Number of Residues	12
Details	4FE4S_FER_1 4Fe-4S ferredoxin-type iron-sulfur binding region signature. CiACKlCEaVCP

Chain	Residue	Details
I	CYS123-PRO134
I	CYS162-PRO173

site_id	PS00535
Number of Residues	12
Details	COMPLEX1_49K Respiratory chain NADH dehydrogenase 49 Kd subunit signature. LHRGtEKLiEyK

Chain	Residue	Details
D	LEU47-LYS58

site_id	PS00542
Number of Residues	22
Details	COMPLEX1_30K Respiratory chain NADH dehydrogenase 30 Kd subunit signature. EREvwDMFgvsfinHpdlRrIL

Chain	Residue	Details
C	GLU112-LEU133

site_id	PS00641
Number of Residues	18
Details	COMPLEX1_75K_1 Respiratory-chain NADH dehydrogenase 75 Kd subunit signature 1. PrfCYhsrlsiaGnCRmC

Chain	Residue	Details
G	PRO103-CYS120

site_id	PS00642
Number of Residues	13
Details	COMPLEX1_75K_2 Respiratory-chain NADH dehydrogenase 75 Kd subunit signature 2. CPiCDqGGeCdLQ

Chain	Residue	Details
G	CYS170-GLN182

site_id	PS00643
Number of Residues	11
Details	COMPLEX1_75K_3 Respiratory-chain NADH dehydrogenase 75 Kd subunit signature 3. RCIqCtRCVrF

Chain	Residue	Details
G	ARG217-PHE227

site_id	PS00644
Number of Residues	16
Details	COMPLEX1_51K_1 Respiratory-chain NADH dehydrogenase 51 Kd subunit signature 1. GAGAYICGEETALLES

Chain	Residue	Details
F	GLY223-SER238

site_id	PS00645
Number of Residues	12
Details	COMPLEX1_51K_2 Respiratory-chain NADH dehydrogenase 51 Kd subunit signature 2. ESCGqCtPCReG

Chain	Residue	Details
F	GLU400-GLY411

site_id	PS01099
Number of Residues	19
Details	COMPLEX1_24K Respiratory-chain NADH dehydrogenase 24 Kd subunit signature. DglFSvgemeCMGcCvnAP

Chain	Residue	Details
E	ASP161-PRO179

site_id	PS01150
Number of Residues	17
Details	COMPLEX1_20K Respiratory-chain NADH dehydrogenase 20 Kd subunit signature. GcDRIVPVDIYvPgCPP

Chain	Residue	Details
B	GLY174-PRO190

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	22
Details	TRANSMEM: Helical => ECO:0000255

Chain	Residue	Details
Z	GLY43-GLY65
I	CYS126
I	CYS129
I	CYS133
I	CYS162
I	CYS165
I	CYS168
I	CYS172

site_id	SWS_FT_FI2
Number of Residues	4
Details	BINDING: BINDING => ECO:0000255\|PROSITE-ProRule:PRU01184

Chain	Residue	Details
G	HIS166
G	CYS170
G	CYS173
G	CYS179

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)