7AQR

Cryo-EM structure of Arabidopsis thaliana Complex-I (peripheral arm)

Functional Information from GO Data

Chain	GOid	namespace	contents
B	0005739	cellular_component	mitochondrion
B	0005886	cellular_component	plasma membrane
B	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
B	0008270	molecular_function	zinc ion binding
B	0009060	biological_process	aerobic respiration
B	0015990	biological_process	electron transport coupled proton transport
B	0016491	molecular_function	oxidoreductase activity
B	0022904	biological_process	respiratory electron transport chain
B	0032981	biological_process	mitochondrial respiratory chain complex I assembly
B	0045271	cellular_component	respiratory chain complex I
B	0046872	molecular_function	metal ion binding
B	0048038	molecular_function	quinone binding
B	0051536	molecular_function	iron-sulfur cluster binding
B	0051539	molecular_function	4 iron, 4 sulfur cluster binding
C	0005634	cellular_component	nucleus
C	0005739	cellular_component	mitochondrion
C	0005743	cellular_component	mitochondrial inner membrane
C	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
C	0008270	molecular_function	zinc ion binding
C	0009536	cellular_component	plastid
C	0016491	molecular_function	oxidoreductase activity
C	0016651	molecular_function	oxidoreductase activity, acting on NAD(P)H
C	0022904	biological_process	respiratory electron transport chain
C	0045271	cellular_component	respiratory chain complex I
C	0050897	molecular_function	cobalt ion binding
C	1902600	biological_process	proton transmembrane transport
D	0005739	cellular_component	mitochondrion
D	0005743	cellular_component	mitochondrial inner membrane
D	0006120	biological_process	mitochondrial electron transport, NADH to ubiquinone
D	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
D	0009536	cellular_component	plastid
D	0016491	molecular_function	oxidoreductase activity
D	0016651	molecular_function	oxidoreductase activity, acting on NAD(P)H
D	0022904	biological_process	respiratory electron transport chain
D	0045271	cellular_component	respiratory chain complex I
D	0048038	molecular_function	quinone binding
D	0051287	molecular_function	NAD binding
D	1902600	biological_process	proton transmembrane transport
E	0003954	molecular_function	NADH dehydrogenase activity
E	0005739	cellular_component	mitochondrion
E	0005743	cellular_component	mitochondrial inner membrane
E	0005829	cellular_component	cytosol
E	0006120	biological_process	mitochondrial electron transport, NADH to ubiquinone
E	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
E	0008270	molecular_function	zinc ion binding
E	0016491	molecular_function	oxidoreductase activity
E	0022904	biological_process	respiratory electron transport chain
E	0045271	cellular_component	respiratory chain complex I
E	0046872	molecular_function	metal ion binding
E	0051536	molecular_function	iron-sulfur cluster binding
E	0051537	molecular_function	2 iron, 2 sulfur cluster binding
E	1902600	biological_process	proton transmembrane transport
F	0005739	cellular_component	mitochondrion
F	0005743	cellular_component	mitochondrial inner membrane
F	0005886	cellular_component	plasma membrane
F	0006120	biological_process	mitochondrial electron transport, NADH to ubiquinone
F	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
F	0010181	molecular_function	FMN binding
F	0016491	molecular_function	oxidoreductase activity
F	0022904	biological_process	respiratory electron transport chain
F	0045271	cellular_component	respiratory chain complex I
F	0046872	molecular_function	metal ion binding
F	0051287	molecular_function	NAD binding
F	0051536	molecular_function	iron-sulfur cluster binding
F	0051539	molecular_function	4 iron, 4 sulfur cluster binding
F	1902600	biological_process	proton transmembrane transport
G	0005739	cellular_component	mitochondrion
G	0005743	cellular_component	mitochondrial inner membrane
G	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
G	0009507	cellular_component	chloroplast
G	0009536	cellular_component	plastid
G	0009853	biological_process	photorespiration
G	0016020	cellular_component	membrane
G	0016491	molecular_function	oxidoreductase activity
G	0016651	molecular_function	oxidoreductase activity, acting on NAD(P)H
G	0022904	biological_process	respiratory electron transport chain
G	0031966	cellular_component	mitochondrial membrane
G	0042773	biological_process	ATP synthesis coupled electron transport
G	0045271	cellular_component	respiratory chain complex I
G	0046872	molecular_function	metal ion binding
G	0051536	molecular_function	iron-sulfur cluster binding
G	0051537	molecular_function	2 iron, 2 sulfur cluster binding
G	0051539	molecular_function	4 iron, 4 sulfur cluster binding
G	1902600	biological_process	proton transmembrane transport
I	0003954	molecular_function	NADH dehydrogenase activity
I	0005739	cellular_component	mitochondrion
I	0006120	biological_process	mitochondrial electron transport, NADH to ubiquinone
I	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
I	0016020	cellular_component	membrane
I	0016491	molecular_function	oxidoreductase activity
I	0016651	molecular_function	oxidoreductase activity, acting on NAD(P)H
I	0022904	biological_process	respiratory electron transport chain
I	0032981	biological_process	mitochondrial respiratory chain complex I assembly
I	0045271	cellular_component	respiratory chain complex I
I	0046872	molecular_function	metal ion binding
I	0051536	molecular_function	iron-sulfur cluster binding
I	0051539	molecular_function	4 iron, 4 sulfur cluster binding
I	1902600	biological_process	proton transmembrane transport
P	0005739	cellular_component	mitochondrion
P	0005759	cellular_component	mitochondrial matrix
P	0006744	biological_process	ubiquinone biosynthetic process
P	0022904	biological_process	respiratory electron transport chain
P	0044877	molecular_function	protein-containing complex binding
P	0045271	cellular_component	respiratory chain complex I
Q	0005739	cellular_component	mitochondrion
Q	0005743	cellular_component	mitochondrial inner membrane
Q	0006970	biological_process	response to osmotic stress
Q	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
Q	0009536	cellular_component	plastid
Q	0009631	biological_process	cold acclimation
Q	0022900	biological_process	electron transport chain
Q	0022904	biological_process	respiratory electron transport chain
Q	0032981	biological_process	mitochondrial respiratory chain complex I assembly
Q	0045271	cellular_component	respiratory chain complex I
Q	0050897	molecular_function	cobalt ion binding
Q	1902600	biological_process	proton transmembrane transport
R	0003674	molecular_function	molecular_function
R	0005739	cellular_component	mitochondrion
R	0005743	cellular_component	mitochondrial inner membrane
R	0006120	biological_process	mitochondrial electron transport, NADH to ubiquinone
R	0022904	biological_process	respiratory electron transport chain
R	0045271	cellular_component	respiratory chain complex I
S	0003674	molecular_function	molecular_function
S	0005739	cellular_component	mitochondrion
S	0005743	cellular_component	mitochondrial inner membrane
S	0008150	biological_process	biological_process
S	0009507	cellular_component	chloroplast
S	0009536	cellular_component	plastid
S	0022904	biological_process	respiratory electron transport chain
S	0045271	cellular_component	respiratory chain complex I
U	0000035	molecular_function	acyl binding
U	0000036	molecular_function	acyl carrier activity
U	0005515	molecular_function	protein binding
U	0005634	cellular_component	nucleus
U	0005739	cellular_component	mitochondrion
U	0005759	cellular_component	mitochondrial matrix
U	0005829	cellular_component	cytosol
U	0006120	biological_process	mitochondrial electron transport, NADH to ubiquinone
U	0006629	biological_process	lipid metabolic process
U	0006631	biological_process	fatty acid metabolic process
U	0006633	biological_process	fatty acid biosynthetic process
U	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
U	0009507	cellular_component	chloroplast
U	0022904	biological_process	respiratory electron transport chain
U	0045271	cellular_component	respiratory chain complex I
U	0046872	molecular_function	metal ion binding
U	0050897	molecular_function	cobalt ion binding
U	1902600	biological_process	proton transmembrane transport
V	0003674	molecular_function	molecular_function
V	0005515	molecular_function	protein binding
V	0005739	cellular_component	mitochondrion
V	0005743	cellular_component	mitochondrial inner membrane
V	0009536	cellular_component	plastid
V	0009853	biological_process	photorespiration
V	0022904	biological_process	respiratory electron transport chain
V	0031966	cellular_component	mitochondrial membrane
V	0045271	cellular_component	respiratory chain complex I
W	0003674	molecular_function	molecular_function
W	0005739	cellular_component	mitochondrion
W	0005743	cellular_component	mitochondrial inner membrane
W	0005829	cellular_component	cytosol
W	0022904	biological_process	respiratory electron transport chain
W	0045271	cellular_component	respiratory chain complex I
Z	0003674	molecular_function	molecular_function
Z	0005576	cellular_component	extracellular region
Z	0005739	cellular_component	mitochondrion
Z	0005743	cellular_component	mitochondrial inner membrane
Z	0009793	biological_process	embryo development ending in seed dormancy
Z	0009853	biological_process	photorespiration
Z	0022904	biological_process	respiratory electron transport chain
Z	0031966	cellular_component	mitochondrial membrane
Z	0045271	cellular_component	respiratory chain complex I
q	0005739	cellular_component	mitochondrion
q	0005743	cellular_component	mitochondrial inner membrane
q	0005829	cellular_component	cytosol
q	0016020	cellular_component	membrane
q	0022904	biological_process	respiratory electron transport chain
q	0045271	cellular_component	respiratory chain complex I
q	0050897	molecular_function	cobalt ion binding
r	0003674	molecular_function	molecular_function
r	0005739	cellular_component	mitochondrion
r	0005886	cellular_component	plasma membrane
r	0008150	biological_process	biological_process

Functional Information from PROSITE/UniProt

site_id	PS00012
Number of Residues	16
Details	PHOSPHOPANTETHEINE Phosphopantetheine attachment site. DLGLDSLDSVEVVMAL

Chain	Residue	Details
U	ASP78-LEU93

---

site_id	PS00198
Number of Residues	12
Details	4FE4S_FER_1 4Fe-4S ferredoxin-type iron-sulfur binding region signature. CiACKlCEaVCP

Chain	Residue	Details
I	CYS123-PRO134
I	CYS162-PRO173

---

site_id	PS00535
Number of Residues	12
Details	COMPLEX1_49K Respiratory chain NADH dehydrogenase 49 Kd subunit signature. LHRGtEKLiEyK

Chain	Residue	Details
D	LEU47-LYS58

---

site_id	PS00542
Number of Residues	22
Details	COMPLEX1_30K Respiratory chain NADH dehydrogenase 30 Kd subunit signature. EREvwDMFgvsfinHpdlRrIL

Chain	Residue	Details
C	GLU112-LEU133

---

site_id	PS00641
Number of Residues	18
Details	COMPLEX1_75K_1 Respiratory-chain NADH dehydrogenase 75 Kd subunit signature 1. PrfCYhsrlsiaGnCRmC

Chain	Residue	Details
G	PRO103-CYS120

---

site_id	PS00642
Number of Residues	13
Details	COMPLEX1_75K_2 Respiratory-chain NADH dehydrogenase 75 Kd subunit signature 2. CPiCDqGGeCdLQ

Chain	Residue	Details
G	CYS170-GLN182

---

site_id	PS00643
Number of Residues	11
Details	COMPLEX1_75K_3 Respiratory-chain NADH dehydrogenase 75 Kd subunit signature 3. RCIqCtRCVrF

Chain	Residue	Details
G	ARG217-PHE227

---

site_id	PS00644
Number of Residues	16
Details	COMPLEX1_51K_1 Respiratory-chain NADH dehydrogenase 51 Kd subunit signature 1. GAGAYICGEETALLES

Chain	Residue	Details
F	GLY223-SER238

---

site_id	PS00645
Number of Residues	12
Details	COMPLEX1_51K_2 Respiratory-chain NADH dehydrogenase 51 Kd subunit signature 2. ESCGqCtPCReG

Chain	Residue	Details
F	GLU400-GLY411

---

site_id	PS01099
Number of Residues	19
Details	COMPLEX1_24K Respiratory-chain NADH dehydrogenase 24 Kd subunit signature. DglFSvgemeCMGcCvnAP

Chain	Residue	Details
E	ASP161-PRO179

---

site_id	PS01150
Number of Residues	17
Details	COMPLEX1_20K Respiratory-chain NADH dehydrogenase 20 Kd subunit signature. GcDRIVPVDIYvPgCPP

Chain	Residue	Details
B	GLY174-PRO190

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	12
Details	Binding site: {"evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	73
Details	Binding site: {"evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	78
Details	Domain: {"description":"2Fe-2S ferredoxin-type","evidences":[{"source":"PROSITE-ProRule","id":"PRU00465","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	39
Details	Domain: {"description":"4Fe-4S His(Cys)3-ligated-type","evidences":[{"source":"PROSITE-ProRule","id":"PRU01184","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	56
Details	Domain: {"description":"4Fe-4S Mo/W bis-MGD-type","evidences":[{"source":"PROSITE-ProRule","id":"PRU01004","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU01184","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	29
Details	Domain: {"description":"4Fe-4S ferredoxin-type 1"}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	29
Details	Domain: {"description":"4Fe-4S ferredoxin-type 2"}

Chain

Residue

Details

---

site_id	SWS_FT_FI9
Number of Residues	75
Details	Domain: {"description":"Carrier","evidences":[{"source":"PROSITE-ProRule","id":"PRU00258","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI10
Number of Residues	1
Details	Modified residue: {"description":"O-(pantetheine 4'-phosphoryl)serine","evidences":[{"source":"PROSITE-ProRule","id":"PRU00258","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---