7AQE

Structure of SARS-CoV-2 Main Protease bound to UNC-2327

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0008233	molecular_function	peptidase activity
A	0019082	biological_process	viral protein processing

Functional Information from PDB Data

site_id	AC1
Number of Residues	5
Details	binding site for residue CL A 401

Chain	Residue
A	SER284
A	SER284
A	ALA285
A	ALA285
A	LEU286

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site_id	AC2
Number of Residues	8
Details	binding site for residue DMS A 402

Chain	Residue
A	THR224
A	ASP263
A	HOH527
A	HOH615
A	GLN74
A	LEU75
A	ARG76
A	PHE223

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site_id	AC3
Number of Residues	2
Details	binding site for residue DMS A 403

Chain	Residue
A	TYR37
A	PHE103

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site_id	AC4
Number of Residues	13
Details	binding site for residue RV5 A 404

Chain	Residue
A	THR25
A	HIS41
A	CYS44
A	THR45
A	SER46
A	MET49
A	ASN142
A	GLU166
A	LEU167
A	PRO168
A	GLN189
A	GLY251
A	HOH661

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site_id	AC5
Number of Residues	3
Details	binding site for residue DMS A 405

Chain	Residue
A	ASN53
A	TYR54
A	GLU55

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	ACT_SITE: For 3CL-PRO activity => ECO:0000255|PROSITE-ProRule:PRU00772, ECO:0000305|PubMed:32198291

Chain	Residue	Details
A	HIS41

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site_id	SWS_FT_FI2
Number of Residues	1
Details	ACT_SITE: Nucleophile; for 3CL-PRO activity => ECO:0000255|PROSITE-ProRule:PRU00772, ECO:0000269|PubMed:32198291

Chain	Residue	Details
A	CYS145

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site_id	SWS_FT_FI3
Number of Residues	1
Details	SITE: Cleavage; by 3CL-PRO => ECO:0000250|UniProtKB:P0C6V3

Chain	Residue	Details
A	GLN306

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site_id	SWS_FT_FI4
Number of Residues	3
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:39223933

Chain	Residue	Details
A	LYS5
A	LYS90

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