7AOU
The Fk1 domain of FKBP51 in complex with (2'R,5'S,12'R)-12'-cyclohexyl-2'-[2-(3,4-dimethoxyphenyl)ethyl]-3',19'-dioxa-10',13',16'-triazaspiro[cyclopropane-1,15'- tricyclo[18.3.1.0-5,10]tetracosane]-1'(24'),20',22'-triene-4',11',14',17'-tetrone
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003755 | molecular_function | peptidyl-prolyl cis-trans isomerase activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 20 |
| Details | binding site for residue RTT A 301 |
| Chain | Residue |
| A | LYS28 |
| A | VAL86 |
| A | ILE87 |
| A | TRP90 |
| A | ALA112 |
| A | TYR113 |
| A | LYS121 |
| A | HOH431 |
| A | HOH484 |
| A | HOH485 |
| A | HOH514 |
| A | LYS29 |
| A | HOH526 |
| A | ASP30 |
| A | ARG31 |
| A | TYR57 |
| A | SER70 |
| A | PHE77 |
| A | GLY84 |
| A | GLN85 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 88 |
| Details | Domain: {"description":"PPIase FKBP-type 1","evidences":[{"source":"PROSITE-ProRule","id":"PRU00277","evidenceCode":"ECO:0000255"}]} |
| site_id | SWS_FT_FI2 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"28147277","evidenceCode":"ECO:0000269"}]} |
