7AOB
Crystal structure of Thermaerobacter marianensis malate dehydrogenase
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003824 | molecular_function | catalytic activity |
| A | 0004459 | molecular_function | L-lactate dehydrogenase activity |
| A | 0006089 | biological_process | lactate metabolic process |
| A | 0006090 | biological_process | pyruvate metabolic process |
| A | 0006099 | biological_process | tricarboxylic acid cycle |
| A | 0016491 | molecular_function | oxidoreductase activity |
| A | 0016616 | molecular_function | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor |
| A | 0019752 | biological_process | carboxylic acid metabolic process |
| A | 0030060 | molecular_function | L-malate dehydrogenase (NAD+) activity |
| B | 0003824 | molecular_function | catalytic activity |
| B | 0004459 | molecular_function | L-lactate dehydrogenase activity |
| B | 0006089 | biological_process | lactate metabolic process |
| B | 0006090 | biological_process | pyruvate metabolic process |
| B | 0006099 | biological_process | tricarboxylic acid cycle |
| B | 0016491 | molecular_function | oxidoreductase activity |
| B | 0016616 | molecular_function | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor |
| B | 0019752 | biological_process | carboxylic acid metabolic process |
| B | 0030060 | molecular_function | L-malate dehydrogenase (NAD+) activity |
| C | 0003824 | molecular_function | catalytic activity |
| C | 0004459 | molecular_function | L-lactate dehydrogenase activity |
| C | 0006089 | biological_process | lactate metabolic process |
| C | 0006090 | biological_process | pyruvate metabolic process |
| C | 0006099 | biological_process | tricarboxylic acid cycle |
| C | 0016491 | molecular_function | oxidoreductase activity |
| C | 0016616 | molecular_function | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor |
| C | 0019752 | biological_process | carboxylic acid metabolic process |
| C | 0030060 | molecular_function | L-malate dehydrogenase (NAD+) activity |
| D | 0003824 | molecular_function | catalytic activity |
| D | 0004459 | molecular_function | L-lactate dehydrogenase activity |
| D | 0006089 | biological_process | lactate metabolic process |
| D | 0006090 | biological_process | pyruvate metabolic process |
| D | 0006099 | biological_process | tricarboxylic acid cycle |
| D | 0016491 | molecular_function | oxidoreductase activity |
| D | 0016616 | molecular_function | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor |
| D | 0019752 | biological_process | carboxylic acid metabolic process |
| D | 0030060 | molecular_function | L-malate dehydrogenase (NAD+) activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 10 |
| Details | binding site for residue GOL A 401 |
| Chain | Residue |
| A | ALA158 |
| D | HOH666 |
| A | ARG159 |
| A | ASN162 |
| A | VAL163 |
| A | PHE165 |
| B | ARG3 |
| B | ASP57 |
| D | ASP244 |
| D | ARG245 |
| site_id | AC2 |
| Number of Residues | 5 |
| Details | binding site for residue PEG A 402 |
| Chain | Residue |
| A | GLN41 |
| A | GLY62 |
| A | HOH563 |
| A | HOH637 |
| A | HOH697 |
| site_id | AC3 |
| Number of Residues | 8 |
| Details | binding site for residue 1PE A 403 |
| Chain | Residue |
| A | ARG159 |
| A | HOH515 |
| A | HOH689 |
| A | HOH704 |
| A | HOH715 |
| B | ASP29 |
| B | VAL59 |
| B | THR61 |
| site_id | AC4 |
| Number of Residues | 6 |
| Details | binding site for residue PEG A 404 |
| Chain | Residue |
| A | ASP34 |
| A | VAL35 |
| A | ILE99 |
| A | HOH555 |
| A | HOH587 |
| A | HOH658 |
| site_id | AC5 |
| Number of Residues | 6 |
| Details | binding site for residue GOL A 405 |
| Chain | Residue |
| A | ASN13 |
| A | ALA16 |
| A | HOH501 |
| A | HOH533 |
| B | ASN13 |
| B | HOH586 |
| site_id | AC6 |
| Number of Residues | 6 |
| Details | binding site for residue GOL A 406 |
| Chain | Residue |
| A | GLY10 |
| A | GLY12 |
| A | ASN13 |
| A | THR14 |
| A | GLY15 |
| A | THR78 |
| site_id | AC7 |
| Number of Residues | 5 |
| Details | binding site for residue GOL A 407 |
| Chain | Residue |
| A | GLU258 |
| A | LYS279 |
| A | ILE280 |
| A | GLU282 |
| A | HOH645 |
| site_id | AC8 |
| Number of Residues | 3 |
| Details | binding site for residue EDO A 408 |
| Chain | Residue |
| A | GLY80 |
| A | LEU119 |
| A | ASN121 |
| site_id | AC9 |
| Number of Residues | 9 |
| Details | binding site for residue GOL B 401 |
| Chain | Residue |
| A | ARG3 |
| A | ASP57 |
| B | ALA158 |
| B | ARG159 |
| B | ASN162 |
| B | VAL163 |
| B | HOH570 |
| C | ASP244 |
| C | ARG245 |
| site_id | AD1 |
| Number of Residues | 11 |
| Details | binding site for residue GOL C 401 |
| Chain | Residue |
| B | ASP244 |
| B | ARG245 |
| C | ALA158 |
| C | ARG159 |
| C | ASN162 |
| C | VAL163 |
| C | PHE165 |
| C | HOH550 |
| C | HOH601 |
| D | ARG3 |
| D | ASP57 |
| site_id | AD2 |
| Number of Residues | 6 |
| Details | binding site for residue PGE C 402 |
| Chain | Residue |
| C | ARG159 |
| C | ARG209 |
| C | HOH545 |
| C | HOH565 |
| C | HOH598 |
| D | THR61 |
| site_id | AD3 |
| Number of Residues | 10 |
| Details | binding site for residue GOL D 401 |
| Chain | Residue |
| A | ASP244 |
| A | ARG245 |
| C | ARG3 |
| C | ASP57 |
| D | ALA158 |
| D | ARG159 |
| D | ASN162 |
| D | VAL163 |
| D | PHE165 |
| D | HOH670 |
| site_id | AD4 |
| Number of Residues | 5 |
| Details | binding site for residue GOL D 402 |
| Chain | Residue |
| D | THR78 |
| D | GLY80 |
| D | THR120 |
| D | ASN121 |
| D | HOH683 |
| site_id | AD5 |
| Number of Residues | 7 |
| Details | binding site for residue GOL D 403 |
| Chain | Residue |
| C | ASN13 |
| C | HOH531 |
| D | ASN13 |
| D | ALA16 |
| D | ALA17 |
| D | HOH505 |
| D | HOH570 |
