Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

7AL8

Structure of ATSI with bovine trypsin

Functional Information from GO Data

Chain	GOid	namespace	contents
B	0004175	molecular_function	endopeptidase activity
B	0004252	molecular_function	serine-type endopeptidase activity
B	0005515	molecular_function	protein binding
B	0005576	cellular_component	extracellular region
B	0005615	cellular_component	extracellular space
B	0006508	biological_process	proteolysis
B	0007586	biological_process	digestion
B	0008236	molecular_function	serine-type peptidase activity
B	0046872	molecular_function	metal ion binding
B	0097180	cellular_component	serine protease inhibitor complex
B	0097655	molecular_function	serpin family protein binding
C	0004867	molecular_function	serine-type endopeptidase inhibitor activity
C	0009611	biological_process	response to wounding
C	0010466	biological_process	negative regulation of peptidase activity
E	0004175	molecular_function	endopeptidase activity
E	0004252	molecular_function	serine-type endopeptidase activity
E	0005515	molecular_function	protein binding
E	0005576	cellular_component	extracellular region
E	0005615	cellular_component	extracellular space
E	0006508	biological_process	proteolysis
E	0007586	biological_process	digestion
E	0008236	molecular_function	serine-type peptidase activity
E	0046872	molecular_function	metal ion binding
E	0097180	cellular_component	serine protease inhibitor complex
E	0097655	molecular_function	serpin family protein binding
F	0004867	molecular_function	serine-type endopeptidase inhibitor activity
F	0009611	biological_process	response to wounding
F	0010466	biological_process	negative regulation of peptidase activity
H	0004175	molecular_function	endopeptidase activity
H	0004252	molecular_function	serine-type endopeptidase activity
H	0005515	molecular_function	protein binding
H	0005576	cellular_component	extracellular region
H	0005615	cellular_component	extracellular space
H	0006508	biological_process	proteolysis
H	0007586	biological_process	digestion
H	0008236	molecular_function	serine-type peptidase activity
H	0046872	molecular_function	metal ion binding
H	0097180	cellular_component	serine protease inhibitor complex
H	0097655	molecular_function	serpin family protein binding
I	0004867	molecular_function	serine-type endopeptidase inhibitor activity
I	0009611	biological_process	response to wounding
I	0010466	biological_process	negative regulation of peptidase activity
K	0004175	molecular_function	endopeptidase activity
K	0004252	molecular_function	serine-type endopeptidase activity
K	0005515	molecular_function	protein binding
K	0005576	cellular_component	extracellular region
K	0005615	cellular_component	extracellular space
K	0006508	biological_process	proteolysis
K	0007586	biological_process	digestion
K	0008236	molecular_function	serine-type peptidase activity
K	0046872	molecular_function	metal ion binding
K	0097180	cellular_component	serine protease inhibitor complex
K	0097655	molecular_function	serpin family protein binding
L	0004867	molecular_function	serine-type endopeptidase inhibitor activity
L	0009611	biological_process	response to wounding
L	0010466	biological_process	negative regulation of peptidase activity
N	0004175	molecular_function	endopeptidase activity
N	0004252	molecular_function	serine-type endopeptidase activity
N	0005515	molecular_function	protein binding
N	0005576	cellular_component	extracellular region
N	0005615	cellular_component	extracellular space
N	0006508	biological_process	proteolysis
N	0007586	biological_process	digestion
N	0008236	molecular_function	serine-type peptidase activity
N	0046872	molecular_function	metal ion binding
N	0097180	cellular_component	serine protease inhibitor complex
N	0097655	molecular_function	serpin family protein binding
O	0004867	molecular_function	serine-type endopeptidase inhibitor activity
O	0009611	biological_process	response to wounding
O	0010466	biological_process	negative regulation of peptidase activity
Q	0004175	molecular_function	endopeptidase activity
Q	0004252	molecular_function	serine-type endopeptidase activity
Q	0005515	molecular_function	protein binding
Q	0005576	cellular_component	extracellular region
Q	0005615	cellular_component	extracellular space
Q	0006508	biological_process	proteolysis
Q	0007586	biological_process	digestion
Q	0008236	molecular_function	serine-type peptidase activity
Q	0046872	molecular_function	metal ion binding
Q	0097180	cellular_component	serine protease inhibitor complex
Q	0097655	molecular_function	serpin family protein binding
R	0004867	molecular_function	serine-type endopeptidase inhibitor activity
R	0009611	biological_process	response to wounding
R	0010466	biological_process	negative regulation of peptidase activity
T	0004175	molecular_function	endopeptidase activity
T	0004252	molecular_function	serine-type endopeptidase activity
T	0005515	molecular_function	protein binding
T	0005576	cellular_component	extracellular region
T	0005615	cellular_component	extracellular space
T	0006508	biological_process	proteolysis
T	0007586	biological_process	digestion
T	0008236	molecular_function	serine-type peptidase activity
T	0046872	molecular_function	metal ion binding
T	0097180	cellular_component	serine protease inhibitor complex
T	0097655	molecular_function	serpin family protein binding
U	0004175	molecular_function	endopeptidase activity
U	0004252	molecular_function	serine-type endopeptidase activity
U	0005515	molecular_function	protein binding
U	0005576	cellular_component	extracellular region
U	0005615	cellular_component	extracellular space
U	0006508	biological_process	proteolysis
U	0007586	biological_process	digestion
U	0008236	molecular_function	serine-type peptidase activity
U	0046872	molecular_function	metal ion binding
U	0097180	cellular_component	serine protease inhibitor complex
U	0097655	molecular_function	serpin family protein binding
V	0004867	molecular_function	serine-type endopeptidase inhibitor activity
V	0009611	biological_process	response to wounding
V	0010466	biological_process	negative regulation of peptidase activity
X	0004867	molecular_function	serine-type endopeptidase inhibitor activity
X	0009611	biological_process	response to wounding
X	0010466	biological_process	negative regulation of peptidase activity

Functional Information from PROSITE/UniProt

site_id	PS00134
Number of Residues	6
Details	TRYPSIN_HIS Serine proteases, trypsin family, histidine active site. VSAAHC

Chain	Residue	Details
U	VAL59-CYS64

site_id	PS00135
Number of Residues	12
Details	TRYPSIN_SER Serine proteases, trypsin family, serine active site. DScqGDSGGPVV

Chain	Residue	Details
U	ASP194-VAL205

site_id	PS00285
Number of Residues	12
Details	POTATO_INHIBITOR Potato inhibitor I family signature. WPELVGeyGykA

Chain	Residue	Details
X	TRP9-ALA20

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	8
Details	SITE: Reactive bond => ECO:0000250

Chain	Residue	Details
X	LYS44
H	HIS63
H	ASP107
H	SER200
K	HIS63
K	ASP107
K	SER200
N	HIS63
N	ASP107
N	SER200
Q	HIS63
C	LYS44
Q	ASP107
Q	SER200
T	HIS63
T	ASP107
T	SER200
F	LYS44
I	LYS44
L	LYS44
O	LYS44
R	LYS44
V	LYS44
E	SER200

site_id	SWS_FT_FI2
Number of Residues	56
Details	BINDING:

Chain	Residue	Details
U	GLU75
B	VAL80
B	GLU85
B	ASP194
B	GLN197
B	SER200
E	GLU75
E	ASN77
E	VAL80
E	GLU85
E	ASP194
U	ASN77
E	GLN197
E	SER200
H	GLU75
H	ASN77
H	VAL80
H	GLU85
H	ASP194
H	GLN197
H	SER200
K	GLU75
U	VAL80
K	ASN77
K	VAL80
K	GLU85
K	ASP194
K	GLN197
K	SER200
N	GLU75
N	ASN77
N	VAL80
N	GLU85
U	GLU85
N	ASP194
N	GLN197
N	SER200
Q	GLU75
Q	ASN77
Q	VAL80
Q	GLU85
Q	ASP194
Q	GLN197
Q	SER200
U	ASP194
T	GLU75
T	ASN77
T	VAL80
T	GLU85
T	ASP194
T	GLN197
T	SER200
U	GLN197
U	SER200
B	GLU75
B	ASN77

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)