Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

7AKR

Human ADP-ribosylserine hydrolase ARH3 mutant E41A in complex with ADP-ribose dimer

This is a non-PDB format compatible entry.

Functional Information from GO Data

Chain	GOid	namespace	contents
AAA	0000287	molecular_function	magnesium ion binding
AAA	0004553	molecular_function	hydrolase activity, hydrolyzing O-glycosyl compounds
AAA	0004649	molecular_function	poly(ADP-ribose) glycohydrolase activity
AAA	0005515	molecular_function	protein binding
AAA	0005634	cellular_component	nucleus
AAA	0005654	cellular_component	nucleoplasm
AAA	0005694	cellular_component	chromosome
AAA	0005737	cellular_component	cytoplasm
AAA	0005739	cellular_component	mitochondrion
AAA	0005759	cellular_component	mitochondrial matrix
AAA	0006281	biological_process	DNA repair
AAA	0006287	biological_process	base-excision repair, gap-filling
AAA	0016604	cellular_component	nuclear body
AAA	0016787	molecular_function	hydrolase activity
AAA	0016799	molecular_function	hydrolase activity, hydrolyzing N-glycosyl compounds
AAA	0046872	molecular_function	metal ion binding
AAA	0060546	biological_process	negative regulation of necroptotic process
AAA	0061463	molecular_function	O-acetyl-ADP-ribose deacetylase activity
AAA	0071451	biological_process	cellular response to superoxide
AAA	0090734	cellular_component	site of DNA damage
AAA	0140290	biological_process	peptidyl-serine ADP-deribosylation
AAA	0140292	molecular_function	ADP-ribosylserine hydrolase activity
BBB	0000287	molecular_function	magnesium ion binding
BBB	0004553	molecular_function	hydrolase activity, hydrolyzing O-glycosyl compounds
BBB	0004649	molecular_function	poly(ADP-ribose) glycohydrolase activity
BBB	0005515	molecular_function	protein binding
BBB	0005634	cellular_component	nucleus
BBB	0005654	cellular_component	nucleoplasm
BBB	0005694	cellular_component	chromosome
BBB	0005737	cellular_component	cytoplasm
BBB	0005739	cellular_component	mitochondrion
BBB	0005759	cellular_component	mitochondrial matrix
BBB	0006281	biological_process	DNA repair
BBB	0006287	biological_process	base-excision repair, gap-filling
BBB	0016604	cellular_component	nuclear body
BBB	0016787	molecular_function	hydrolase activity
BBB	0016799	molecular_function	hydrolase activity, hydrolyzing N-glycosyl compounds
BBB	0046872	molecular_function	metal ion binding
BBB	0060546	biological_process	negative regulation of necroptotic process
BBB	0061463	molecular_function	O-acetyl-ADP-ribose deacetylase activity
BBB	0071451	biological_process	cellular response to superoxide
BBB	0090734	cellular_component	site of DNA damage
BBB	0140290	biological_process	peptidyl-serine ADP-deribosylation
BBB	0140292	molecular_function	ADP-ribosylserine hydrolase activity
CCC	0000287	molecular_function	magnesium ion binding
CCC	0004553	molecular_function	hydrolase activity, hydrolyzing O-glycosyl compounds
CCC	0004649	molecular_function	poly(ADP-ribose) glycohydrolase activity
CCC	0005515	molecular_function	protein binding
CCC	0005634	cellular_component	nucleus
CCC	0005654	cellular_component	nucleoplasm
CCC	0005694	cellular_component	chromosome
CCC	0005737	cellular_component	cytoplasm
CCC	0005739	cellular_component	mitochondrion
CCC	0005759	cellular_component	mitochondrial matrix
CCC	0006281	biological_process	DNA repair
CCC	0006287	biological_process	base-excision repair, gap-filling
CCC	0016604	cellular_component	nuclear body
CCC	0016787	molecular_function	hydrolase activity
CCC	0016799	molecular_function	hydrolase activity, hydrolyzing N-glycosyl compounds
CCC	0046872	molecular_function	metal ion binding
CCC	0060546	biological_process	negative regulation of necroptotic process
CCC	0061463	molecular_function	O-acetyl-ADP-ribose deacetylase activity
CCC	0071451	biological_process	cellular response to superoxide
CCC	0090734	cellular_component	site of DNA damage
CCC	0140290	biological_process	peptidyl-serine ADP-deribosylation
CCC	0140292	molecular_function	ADP-ribosylserine hydrolase activity
DDD	0000287	molecular_function	magnesium ion binding
DDD	0004553	molecular_function	hydrolase activity, hydrolyzing O-glycosyl compounds
DDD	0004649	molecular_function	poly(ADP-ribose) glycohydrolase activity
DDD	0005515	molecular_function	protein binding
DDD	0005634	cellular_component	nucleus
DDD	0005654	cellular_component	nucleoplasm
DDD	0005694	cellular_component	chromosome
DDD	0005737	cellular_component	cytoplasm
DDD	0005739	cellular_component	mitochondrion
DDD	0005759	cellular_component	mitochondrial matrix
DDD	0006281	biological_process	DNA repair
DDD	0006287	biological_process	base-excision repair, gap-filling
DDD	0016604	cellular_component	nuclear body
DDD	0016787	molecular_function	hydrolase activity
DDD	0016799	molecular_function	hydrolase activity, hydrolyzing N-glycosyl compounds
DDD	0046872	molecular_function	metal ion binding
DDD	0060546	biological_process	negative regulation of necroptotic process
DDD	0061463	molecular_function	O-acetyl-ADP-ribose deacetylase activity
DDD	0071451	biological_process	cellular response to superoxide
DDD	0090734	cellular_component	site of DNA damage
DDD	0140290	biological_process	peptidyl-serine ADP-deribosylation
DDD	0140292	molecular_function	ADP-ribosylserine hydrolase activity

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	BINDING: BINDING => ECO:0000269\|PubMed:21892188, ECO:0000269\|PubMed:29907568, ECO:0000269\|PubMed:30045870, ECO:0007744\|PDB:5ZQY, ECO:0007744\|PDB:6D36, ECO:0007744\|PDB:6D3A

Chain	Residue	Details
AAA	ALA41
BBB	ALA41
CCC	ALA41
DDD	ALA41

site_id	SWS_FT_FI2
Number of Residues	4
Details	BINDING: BINDING => ECO:0000269\|PubMed:21892188, ECO:0000269\|PubMed:29907568, ECO:0000269\|PubMed:30045870, ECO:0000269\|PubMed:33894202, ECO:0007744\|PDB:5ZQY, ECO:0007744\|PDB:6D36, ECO:0007744\|PDB:6D3A, ECO:0007744\|PDB:7L9I

Chain	Residue	Details
DDD	THR76
AAA	THR76
BBB	THR76
CCC	THR76

site_id	SWS_FT_FI3
Number of Residues	12
Details	BINDING: BINDING => ECO:0000269\|PubMed:29907568, ECO:0000269\|PubMed:30045870, ECO:0007744\|PDB:5ZQY, ECO:0007744\|PDB:6D36, ECO:0007744\|PDB:6D3A

Chain	Residue	Details
BBB	LYS146
BBB	HIS182
CCC	ASP77
CCC	LYS146
CCC	HIS182
DDD	ASP77
DDD	LYS146
DDD	HIS182
AAA	HIS182
BBB	ASP77
AAA	ASP77
AAA	LYS146

site_id	SWS_FT_FI4
Number of Residues	4
Details	BINDING: BINDING => ECO:0000269\|PubMed:34321462, ECO:0007744\|PDB:7ARW

Chain	Residue	Details
DDD	ASP78
AAA	ASP78
BBB	ASP78
CCC	ASP78

site_id	SWS_FT_FI5
Number of Residues	8
Details	BINDING: BINDING => ECO:0000269\|PubMed:29907568, ECO:0007744\|PDB:6D36, ECO:0007744\|PDB:6D3A

Chain	Residue	Details
AAA	LEU235
AAA	ILE271
BBB	LEU235
BBB	ILE271
CCC	LEU235
CCC	ILE271
DDD	LEU235
DDD	ILE271

site_id	SWS_FT_FI6
Number of Residues	8
Details	BINDING: BINDING => ECO:0000269\|PubMed:21892188, ECO:0000269\|PubMed:29907568, ECO:0000269\|PubMed:30045870, ECO:0000269\|PubMed:33894202, ECO:0000269\|PubMed:34321462, ECO:0007744\|PDB:5ZQY, ECO:0007744\|PDB:6D36, ECO:0007744\|PDB:6D3A, ECO:0007744\|PDB:7AKR, ECO:0007744\|PDB:7AKS, ECO:0007744\|PDB:7ARW, ECO:0007744\|PDB:7L9H

Chain	Residue	Details
CCC	ASP314
CCC	ASP316
DDD	ASP314
DDD	ASP316
AAA	ASP314
AAA	ASP316
BBB	ASP314
BBB	ASP316

site_id	SWS_FT_FI7
Number of Residues	4
Details	BINDING: BINDING => ECO:0000269\|PubMed:21892188, ECO:0000269\|PubMed:29907568, ECO:0000269\|PubMed:30045870, ECO:0000269\|PubMed:33894202, ECO:0007744\|PDB:5ZQY, ECO:0007744\|PDB:6D36, ECO:0007744\|PDB:6D3A, ECO:0007744\|PDB:7L9H

Chain	Residue	Details
AAA	THR317
BBB	THR317
CCC	THR317
DDD	THR317

site_id	SWS_FT_FI8
Number of Residues	4
Details	SITE: Glutamate flap => ECO:0000269\|PubMed:29907568, ECO:0000269\|PubMed:30045870

Chain	Residue	Details
AAA	ALA41
BBB	ALA41
CCC	ALA41
DDD	ALA41

site_id	SWS_FT_FI9
Number of Residues	4
Details	MOD_RES: Phosphothreonine => ECO:0007744\|PubMed:23186163

Chain	Residue	Details
AAA	THR64
BBB	THR64
CCC	THR64
DDD	THR64

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)