7AKR

Human ADP-ribosylserine hydrolase ARH3 mutant E41A in complex with ADP-ribose dimer

This is a non-PDB format compatible entry.

Functional Information from GO Data

Chain	GOid	namespace	contents
AAA	0000287	molecular_function	magnesium ion binding
AAA	0004553	molecular_function	hydrolase activity, hydrolyzing O-glycosyl compounds
AAA	0004649	molecular_function	poly(ADP-ribose) glycohydrolase activity
AAA	0005515	molecular_function	protein binding
AAA	0005634	cellular_component	nucleus
AAA	0005654	cellular_component	nucleoplasm
AAA	0005694	cellular_component	chromosome
AAA	0005737	cellular_component	cytoplasm
AAA	0005739	cellular_component	mitochondrion
AAA	0005759	cellular_component	mitochondrial matrix
AAA	0006281	biological_process	DNA repair
AAA	0006287	biological_process	base-excision repair, gap-filling
AAA	0006974	biological_process	DNA damage response
AAA	0016787	molecular_function	hydrolase activity
AAA	0046872	molecular_function	metal ion binding
AAA	0060546	biological_process	negative regulation of necroptotic process
AAA	0061463	molecular_function	O-acetyl-ADP-ribose deacetylase activity
AAA	0071451	biological_process	cellular response to superoxide
AAA	0090734	cellular_component	site of DNA damage
AAA	0140290	biological_process	peptidyl-serine ADP-deribosylation
AAA	0140292	molecular_function	ADP-ribosylserine hydrolase activity
BBB	0000287	molecular_function	magnesium ion binding
BBB	0004553	molecular_function	hydrolase activity, hydrolyzing O-glycosyl compounds
BBB	0004649	molecular_function	poly(ADP-ribose) glycohydrolase activity
BBB	0005515	molecular_function	protein binding
BBB	0005634	cellular_component	nucleus
BBB	0005654	cellular_component	nucleoplasm
BBB	0005694	cellular_component	chromosome
BBB	0005737	cellular_component	cytoplasm
BBB	0005739	cellular_component	mitochondrion
BBB	0005759	cellular_component	mitochondrial matrix
BBB	0006281	biological_process	DNA repair
BBB	0006287	biological_process	base-excision repair, gap-filling
BBB	0006974	biological_process	DNA damage response
BBB	0016787	molecular_function	hydrolase activity
BBB	0046872	molecular_function	metal ion binding
BBB	0060546	biological_process	negative regulation of necroptotic process
BBB	0061463	molecular_function	O-acetyl-ADP-ribose deacetylase activity
BBB	0071451	biological_process	cellular response to superoxide
BBB	0090734	cellular_component	site of DNA damage
BBB	0140290	biological_process	peptidyl-serine ADP-deribosylation
BBB	0140292	molecular_function	ADP-ribosylserine hydrolase activity
CCC	0000287	molecular_function	magnesium ion binding
CCC	0004553	molecular_function	hydrolase activity, hydrolyzing O-glycosyl compounds
CCC	0004649	molecular_function	poly(ADP-ribose) glycohydrolase activity
CCC	0005515	molecular_function	protein binding
CCC	0005634	cellular_component	nucleus
CCC	0005654	cellular_component	nucleoplasm
CCC	0005694	cellular_component	chromosome
CCC	0005737	cellular_component	cytoplasm
CCC	0005739	cellular_component	mitochondrion
CCC	0005759	cellular_component	mitochondrial matrix
CCC	0006281	biological_process	DNA repair
CCC	0006287	biological_process	base-excision repair, gap-filling
CCC	0006974	biological_process	DNA damage response
CCC	0016787	molecular_function	hydrolase activity
CCC	0046872	molecular_function	metal ion binding
CCC	0060546	biological_process	negative regulation of necroptotic process
CCC	0061463	molecular_function	O-acetyl-ADP-ribose deacetylase activity
CCC	0071451	biological_process	cellular response to superoxide
CCC	0090734	cellular_component	site of DNA damage
CCC	0140290	biological_process	peptidyl-serine ADP-deribosylation
CCC	0140292	molecular_function	ADP-ribosylserine hydrolase activity
DDD	0000287	molecular_function	magnesium ion binding
DDD	0004553	molecular_function	hydrolase activity, hydrolyzing O-glycosyl compounds
DDD	0004649	molecular_function	poly(ADP-ribose) glycohydrolase activity
DDD	0005515	molecular_function	protein binding
DDD	0005634	cellular_component	nucleus
DDD	0005654	cellular_component	nucleoplasm
DDD	0005694	cellular_component	chromosome
DDD	0005737	cellular_component	cytoplasm
DDD	0005739	cellular_component	mitochondrion
DDD	0005759	cellular_component	mitochondrial matrix
DDD	0006281	biological_process	DNA repair
DDD	0006287	biological_process	base-excision repair, gap-filling
DDD	0006974	biological_process	DNA damage response
DDD	0016787	molecular_function	hydrolase activity
DDD	0046872	molecular_function	metal ion binding
DDD	0060546	biological_process	negative regulation of necroptotic process
DDD	0061463	molecular_function	O-acetyl-ADP-ribose deacetylase activity
DDD	0071451	biological_process	cellular response to superoxide
DDD	0090734	cellular_component	site of DNA damage
DDD	0140290	biological_process	peptidyl-serine ADP-deribosylation
DDD	0140292	molecular_function	ADP-ribosylserine hydrolase activity

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"PubMed","id":"21892188","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"29907568","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"30045870","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5ZQY","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6D36","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6D3A","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"PubMed","id":"21892188","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"29907568","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"30045870","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"33894202","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5ZQY","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6D36","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6D3A","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7L9I","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	32
Details	Binding site: {"evidences":[{"source":"PubMed","id":"29907568","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"30045870","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5ZQY","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6D36","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6D3A","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"PubMed","id":"34321462","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7ARW","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	8
Details	Binding site: {"evidences":[{"source":"PubMed","id":"29907568","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6D36","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6D3A","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	8
Details	Binding site: {"evidences":[{"source":"PubMed","id":"21892188","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"29907568","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"30045870","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"33894202","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"34321462","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5ZQY","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6D36","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6D3A","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7AKR","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7AKS","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7ARW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7L9H","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"PubMed","id":"21892188","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"29907568","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"30045870","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"33894202","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5ZQY","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6D36","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6D3A","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7L9H","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	4
Details	Site: {"description":"Glutamate flap","evidences":[{"source":"PubMed","id":"29907568","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"30045870","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI9
Number of Residues	2
Details	Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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