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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

7AKR

Human ADP-ribosylserine hydrolase ARH3 mutant E41A in complex with ADP-ribose dimer

This is a non-PDB format compatible entry.
Functional Information from GO Data
ChainGOidnamespacecontents
AAA0000287molecular_functionmagnesium ion binding
AAA0004553molecular_functionhydrolase activity, hydrolyzing O-glycosyl compounds
AAA0004649molecular_functionpoly(ADP-ribose) glycohydrolase activity
AAA0005515molecular_functionprotein binding
AAA0005634cellular_componentnucleus
AAA0005654cellular_componentnucleoplasm
AAA0005694cellular_componentchromosome
AAA0005737cellular_componentcytoplasm
AAA0005739cellular_componentmitochondrion
AAA0005759cellular_componentmitochondrial matrix
AAA0006281biological_processDNA repair
AAA0006287biological_processbase-excision repair, gap-filling
AAA0006974biological_processDNA damage response
AAA0016604cellular_componentnuclear body
AAA0016787molecular_functionhydrolase activity
AAA0046872molecular_functionmetal ion binding
AAA0060546biological_processnegative regulation of necroptotic process
AAA0061463molecular_functionO-acetyl-ADP-ribose deacetylase activity
AAA0071451biological_processcellular response to superoxide
AAA0090734cellular_componentsite of DNA damage
AAA0140290biological_processpeptidyl-serine ADP-deribosylation
AAA0140292molecular_functionADP-ribosylserine hydrolase activity
BBB0000287molecular_functionmagnesium ion binding
BBB0004553molecular_functionhydrolase activity, hydrolyzing O-glycosyl compounds
BBB0004649molecular_functionpoly(ADP-ribose) glycohydrolase activity
BBB0005515molecular_functionprotein binding
BBB0005634cellular_componentnucleus
BBB0005654cellular_componentnucleoplasm
BBB0005694cellular_componentchromosome
BBB0005737cellular_componentcytoplasm
BBB0005739cellular_componentmitochondrion
BBB0005759cellular_componentmitochondrial matrix
BBB0006281biological_processDNA repair
BBB0006287biological_processbase-excision repair, gap-filling
BBB0006974biological_processDNA damage response
BBB0016604cellular_componentnuclear body
BBB0016787molecular_functionhydrolase activity
BBB0046872molecular_functionmetal ion binding
BBB0060546biological_processnegative regulation of necroptotic process
BBB0061463molecular_functionO-acetyl-ADP-ribose deacetylase activity
BBB0071451biological_processcellular response to superoxide
BBB0090734cellular_componentsite of DNA damage
BBB0140290biological_processpeptidyl-serine ADP-deribosylation
BBB0140292molecular_functionADP-ribosylserine hydrolase activity
CCC0000287molecular_functionmagnesium ion binding
CCC0004553molecular_functionhydrolase activity, hydrolyzing O-glycosyl compounds
CCC0004649molecular_functionpoly(ADP-ribose) glycohydrolase activity
CCC0005515molecular_functionprotein binding
CCC0005634cellular_componentnucleus
CCC0005654cellular_componentnucleoplasm
CCC0005694cellular_componentchromosome
CCC0005737cellular_componentcytoplasm
CCC0005739cellular_componentmitochondrion
CCC0005759cellular_componentmitochondrial matrix
CCC0006281biological_processDNA repair
CCC0006287biological_processbase-excision repair, gap-filling
CCC0006974biological_processDNA damage response
CCC0016604cellular_componentnuclear body
CCC0016787molecular_functionhydrolase activity
CCC0046872molecular_functionmetal ion binding
CCC0060546biological_processnegative regulation of necroptotic process
CCC0061463molecular_functionO-acetyl-ADP-ribose deacetylase activity
CCC0071451biological_processcellular response to superoxide
CCC0090734cellular_componentsite of DNA damage
CCC0140290biological_processpeptidyl-serine ADP-deribosylation
CCC0140292molecular_functionADP-ribosylserine hydrolase activity
DDD0000287molecular_functionmagnesium ion binding
DDD0004553molecular_functionhydrolase activity, hydrolyzing O-glycosyl compounds
DDD0004649molecular_functionpoly(ADP-ribose) glycohydrolase activity
DDD0005515molecular_functionprotein binding
DDD0005634cellular_componentnucleus
DDD0005654cellular_componentnucleoplasm
DDD0005694cellular_componentchromosome
DDD0005737cellular_componentcytoplasm
DDD0005739cellular_componentmitochondrion
DDD0005759cellular_componentmitochondrial matrix
DDD0006281biological_processDNA repair
DDD0006287biological_processbase-excision repair, gap-filling
DDD0006974biological_processDNA damage response
DDD0016604cellular_componentnuclear body
DDD0016787molecular_functionhydrolase activity
DDD0046872molecular_functionmetal ion binding
DDD0060546biological_processnegative regulation of necroptotic process
DDD0061463molecular_functionO-acetyl-ADP-ribose deacetylase activity
DDD0071451biological_processcellular response to superoxide
DDD0090734cellular_componentsite of DNA damage
DDD0140290biological_processpeptidyl-serine ADP-deribosylation
DDD0140292molecular_functionADP-ribosylserine hydrolase activity
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues4
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"21892188","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"29907568","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"30045870","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5ZQY","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6D36","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6D3A","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI2
Number of Residues4
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"21892188","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"29907568","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"30045870","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"33894202","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5ZQY","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6D36","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6D3A","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7L9I","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI3
Number of Residues32
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"29907568","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"30045870","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5ZQY","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6D36","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6D3A","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI4
Number of Residues4
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"34321462","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7ARW","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI5
Number of Residues8
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"29907568","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6D36","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6D3A","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI6
Number of Residues8
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"21892188","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"29907568","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"30045870","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"33894202","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"34321462","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5ZQY","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6D36","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6D3A","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7AKR","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7AKS","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7ARW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7L9H","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI7
Number of Residues4
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"21892188","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"29907568","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"30045870","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"33894202","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5ZQY","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6D36","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6D3A","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7L9H","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI8
Number of Residues4
DetailsSite: {"description":"Glutamate flap","evidences":[{"source":"PubMed","id":"29907568","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"30045870","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI9
Number of Residues2
DetailsModified residue: {"description":"Phosphothreonine","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

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PDB entries from 2025-10-22

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