7AH8
NF-Y bound to suramin inhibitor
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0001228 | molecular_function | DNA-binding transcription activator activity, RNA polymerase II-specific |
| A | 0005634 | cellular_component | nucleus |
| A | 0006355 | biological_process | regulation of DNA-templated transcription |
| A | 0016602 | cellular_component | CCAAT-binding factor complex |
| A | 0043565 | molecular_function | sequence-specific DNA binding |
| A | 0046982 | molecular_function | protein heterodimerization activity |
| B | 0003677 | molecular_function | DNA binding |
| B | 0046982 | molecular_function | protein heterodimerization activity |
| C | 0001228 | molecular_function | DNA-binding transcription activator activity, RNA polymerase II-specific |
| C | 0005634 | cellular_component | nucleus |
| C | 0006355 | biological_process | regulation of DNA-templated transcription |
| C | 0016602 | cellular_component | CCAAT-binding factor complex |
| C | 0043565 | molecular_function | sequence-specific DNA binding |
| C | 0046982 | molecular_function | protein heterodimerization activity |
| D | 0003677 | molecular_function | DNA binding |
| D | 0046982 | molecular_function | protein heterodimerization activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 5 |
| Details | binding site for residue GOL B 201 |
| Chain | Residue |
| B | PRO44 |
| B | LEU45 |
| D | GLN41 |
| D | LEU45 |
| D | SVR201 |
| site_id | AC2 |
| Number of Residues | 1 |
| Details | binding site for residue FLC C 201 |
| Chain | Residue |
| C | HOH305 |
| site_id | AC3 |
| Number of Residues | 24 |
| Details | binding site for residue SVR D 201 |
| Chain | Residue |
| B | LYS49 |
| B | LYS53 |
| B | LYS59 |
| B | MET60 |
| B | ILE61 |
| B | SER62 |
| B | ALA63 |
| B | PRO66 |
| B | GOL201 |
| C | PHE139 |
| C | ARG140 |
| D | GLN41 |
| D | LYS49 |
| D | LYS53 |
| D | LYS59 |
| D | MET60 |
| D | ILE61 |
| D | SER62 |
| D | ALA63 |
| D | GLU64 |
| D | PRO66 |
| A | PHE139 |
| A | ARG140 |
| B | LEU45 |
Functional Information from PROSITE/UniProt
| site_id | PS00685 |
| Number of Residues | 17 |
| Details | NFYB_HAP3 NF-YB/HAP3 subunit signature. CVSEfISFITSEASERC |
| Chain | Residue | Details |
| A | CYS87-CYS103 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 12 |
| Details | DNA_BIND: DNA_BIND => ECO:0000250 |
| Chain | Residue | Details |
| A | LEU57-ALA63 | |
| C | LEU57-ALA63 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 4 |
| Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:23332751 |
| Chain | Residue | Details |
| A | LYS138 | |
| C | LYS138 |
