7AG8
Cryo-EM structure of wild-type KatG from M. tuberculosis
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004096 | molecular_function | catalase activity |
| A | 0004601 | molecular_function | peroxidase activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0005576 | cellular_component | extracellular region |
| A | 0005829 | cellular_component | cytosol |
| A | 0005886 | cellular_component | plasma membrane |
| A | 0006979 | biological_process | response to oxidative stress |
| A | 0009274 | cellular_component | peptidoglycan-based cell wall |
| A | 0016491 | molecular_function | oxidoreductase activity |
| A | 0016677 | molecular_function | oxidoreductase activity, acting on a heme group of donors, nitrogenous group as acceptor |
| A | 0020037 | molecular_function | heme binding |
| A | 0042744 | biological_process | hydrogen peroxide catabolic process |
| A | 0045739 | biological_process | positive regulation of DNA repair |
| A | 0046677 | biological_process | response to antibiotic |
| A | 0046872 | molecular_function | metal ion binding |
| A | 0070301 | biological_process | cellular response to hydrogen peroxide |
| A | 0070402 | molecular_function | NADPH binding |
| A | 0070404 | molecular_function | NADH binding |
| A | 0098869 | biological_process | cellular oxidant detoxification |
| B | 0004096 | molecular_function | catalase activity |
| B | 0004601 | molecular_function | peroxidase activity |
| B | 0005515 | molecular_function | protein binding |
| B | 0005576 | cellular_component | extracellular region |
| B | 0005829 | cellular_component | cytosol |
| B | 0005886 | cellular_component | plasma membrane |
| B | 0006979 | biological_process | response to oxidative stress |
| B | 0009274 | cellular_component | peptidoglycan-based cell wall |
| B | 0016491 | molecular_function | oxidoreductase activity |
| B | 0016677 | molecular_function | oxidoreductase activity, acting on a heme group of donors, nitrogenous group as acceptor |
| B | 0020037 | molecular_function | heme binding |
| B | 0042744 | biological_process | hydrogen peroxide catabolic process |
| B | 0045739 | biological_process | positive regulation of DNA repair |
| B | 0046677 | biological_process | response to antibiotic |
| B | 0046872 | molecular_function | metal ion binding |
| B | 0070301 | biological_process | cellular response to hydrogen peroxide |
| B | 0070402 | molecular_function | NADPH binding |
| B | 0070404 | molecular_function | NADH binding |
| B | 0098869 | biological_process | cellular oxidant detoxification |
Functional Information from PROSITE/UniProt
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | Active site: {"description":"Proton acceptor","evidences":[{"source":"HAMAP-Rule","id":"MF_01961","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | Binding site: {"description":"axial binding residue","evidences":[{"source":"PubMed","id":"15231843","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16566587","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"24185282","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1SJ2","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2CCA","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2CCD","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4C51","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | Site: {"description":"Transition state stabilizer","evidences":[{"source":"HAMAP-Rule","id":"MF_01961","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 4 |
| Details | Cross-link: {"description":"Tryptophyl-tyrosyl-methioninium (Tyr-Met) (with W-107); alternate","evidences":[{"source":"HAMAP-Rule","id":"MF_01961","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"15231843","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 2 |
| Details | Active site: {"description":"Tryptophan radical intermediate","evidences":[{"source":"PubMed","id":"18052167","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 1 |
| Details | Cross-link: {"description":"Tryptophyl-tyrosyl-methioninium (Trp-Tyr) (with M-255); alternate","evidences":[{"source":"HAMAP-Rule","id":"MF_01961","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"15231843","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
