7AG4
Crystal structure of active site mutant of SQ Isomerase (YihS-H248A) from Salmonella enterica in complex with sulfofructose (SF)
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005975 | biological_process | carbohydrate metabolic process |
| A | 0016853 | molecular_function | isomerase activity |
| A | 0061593 | molecular_function | sulfoquinovose isomerase activity |
| A | 0061720 | biological_process | 6-sulfoquinovose(1-) catabolic process to glycerone phosphate and 3-sulfolactaldehyde |
| A | 1902777 | biological_process | 6-sulfoquinovose(1-) catabolic process |
| B | 0005975 | biological_process | carbohydrate metabolic process |
| B | 0016853 | molecular_function | isomerase activity |
| B | 0061593 | molecular_function | sulfoquinovose isomerase activity |
| B | 0061720 | biological_process | 6-sulfoquinovose(1-) catabolic process to glycerone phosphate and 3-sulfolactaldehyde |
| B | 1902777 | biological_process | 6-sulfoquinovose(1-) catabolic process |
| C | 0005975 | biological_process | carbohydrate metabolic process |
| C | 0016853 | molecular_function | isomerase activity |
| C | 0061593 | molecular_function | sulfoquinovose isomerase activity |
| C | 0061720 | biological_process | 6-sulfoquinovose(1-) catabolic process to glycerone phosphate and 3-sulfolactaldehyde |
| C | 1902777 | biological_process | 6-sulfoquinovose(1-) catabolic process |
| D | 0005975 | biological_process | carbohydrate metabolic process |
| D | 0016853 | molecular_function | isomerase activity |
| D | 0061593 | molecular_function | sulfoquinovose isomerase activity |
| D | 0061720 | biological_process | 6-sulfoquinovose(1-) catabolic process to glycerone phosphate and 3-sulfolactaldehyde |
| D | 1902777 | biological_process | 6-sulfoquinovose(1-) catabolic process |
| E | 0005975 | biological_process | carbohydrate metabolic process |
| E | 0016853 | molecular_function | isomerase activity |
| E | 0061593 | molecular_function | sulfoquinovose isomerase activity |
| E | 0061720 | biological_process | 6-sulfoquinovose(1-) catabolic process to glycerone phosphate and 3-sulfolactaldehyde |
| E | 1902777 | biological_process | 6-sulfoquinovose(1-) catabolic process |
| F | 0005975 | biological_process | carbohydrate metabolic process |
| F | 0016853 | molecular_function | isomerase activity |
| F | 0061593 | molecular_function | sulfoquinovose isomerase activity |
| F | 0061720 | biological_process | 6-sulfoquinovose(1-) catabolic process to glycerone phosphate and 3-sulfolactaldehyde |
| F | 1902777 | biological_process | 6-sulfoquinovose(1-) catabolic process |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 17 |
| Details | binding site for residue RB8 A 501 |
| Chain | Residue |
| A | TRP51 |
| A | GLN362 |
| A | TRP375 |
| A | GLN379 |
| A | ASP380 |
| A | HIS383 |
| A | HOH647 |
| A | HOH670 |
| A | HOH674 |
| A | ARG55 |
| A | TYR111 |
| A | ASN172 |
| A | HIS176 |
| A | ARG238 |
| A | PHE239 |
| A | GLU251 |
| A | TRP316 |
| site_id | AC2 |
| Number of Residues | 17 |
| Details | binding site for residue RB8 B 501 |
| Chain | Residue |
| B | TRP51 |
| B | ARG55 |
| B | TYR111 |
| B | ASN172 |
| B | MET175 |
| B | HIS176 |
| B | ARG238 |
| B | PHE239 |
| B | GLU251 |
| B | TRP316 |
| B | GLN362 |
| B | TRP375 |
| B | GLN379 |
| B | ASP380 |
| B | HIS383 |
| B | HOH646 |
| B | HOH658 |
| site_id | AC3 |
| Number of Residues | 17 |
| Details | binding site for residue RB8 D 501 |
| Chain | Residue |
| D | TRP51 |
| D | ARG55 |
| D | TYR111 |
| D | ASN172 |
| D | MET175 |
| D | HIS176 |
| D | ARG238 |
| D | PHE239 |
| D | GLU251 |
| D | TRP316 |
| D | GLN362 |
| D | TRP375 |
| D | GLN379 |
| D | ASP380 |
| D | HIS383 |
| D | HOH612 |
| D | HOH613 |
| site_id | AC4 |
| Number of Residues | 13 |
| Details | binding site for residue RB8 F 501 |
| Chain | Residue |
| F | TRP51 |
| F | ARG55 |
| F | ASN172 |
| F | MET175 |
| F | HIS176 |
| F | GLU251 |
| F | TRP316 |
| F | GLN362 |
| F | GLN379 |
| F | ASP380 |
| F | HIS383 |
| F | HOH604 |
| F | HOH616 |
| site_id | AC5 |
| Number of Residues | 17 |
| Details | binding site for residue RB8 C 501 |
| Chain | Residue |
| C | TRP51 |
| C | ARG55 |
| C | TYR111 |
| C | ASN172 |
| C | MET175 |
| C | HIS176 |
| C | ARG238 |
| C | PHE239 |
| C | GLU251 |
| C | TRP316 |
| C | GLN362 |
| C | TRP375 |
| C | GLN379 |
| C | ASP380 |
| C | HIS383 |
| C | HOH642 |
| C | HOH681 |
| site_id | AC6 |
| Number of Residues | 14 |
| Details | binding site for residue RB8 E 501 |
| Chain | Residue |
| E | TRP51 |
| E | ARG55 |
| E | TYR111 |
| E | ASN172 |
| E | MET175 |
| E | HIS176 |
| E | GLU251 |
| E | TRP316 |
| E | GLN362 |
| E | GLN379 |
| E | ASP380 |
| E | HIS383 |
| E | HOH608 |
| E | HOH625 |
Functional Information from PROSITE/UniProt
| site_id | PS01295 |
| Number of Residues | 8 |
| Details | ISPD 4-diphosphocytidyl-2C-methyl-D-erythritol synthase signature. VIIHDVAR |
| Chain | Residue | Details |
| A | VAL203-ARG210 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 12 |
| Details | Active site: {"description":"Proton donor/acceptor","evidences":[{"source":"HAMAP-Rule","id":"MF_00998","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"18328504","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"33791429","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 34 |
| Details | Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_00998","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"18328504","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"33791429","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"7AG4","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 18 |
| Details | Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_00998","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"33791429","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"7AG4","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
