7AEV

Pressure wave-exposed human hemoglobin: pump/probe data (3500 indexed images)

This is a non-PDB format compatible entry.

Functional Information from GO Data

Chain	GOid	namespace	contents
AAA	0004601	molecular_function	peroxidase activity
AAA	0005344	molecular_function	oxygen carrier activity
AAA	0005506	molecular_function	iron ion binding
AAA	0005515	molecular_function	protein binding
AAA	0005576	cellular_component	extracellular region
AAA	0005615	cellular_component	extracellular space
AAA	0005829	cellular_component	cytosol
AAA	0005833	cellular_component	hemoglobin complex
AAA	0015670	biological_process	carbon dioxide transport
AAA	0015671	biological_process	oxygen transport
AAA	0016020	cellular_component	membrane
AAA	0019825	molecular_function	oxygen binding
AAA	0020037	molecular_function	heme binding
AAA	0030185	biological_process	nitric oxide transport
AAA	0031720	molecular_function	haptoglobin binding
AAA	0031838	cellular_component	haptoglobin-hemoglobin complex
AAA	0042542	biological_process	response to hydrogen peroxide
AAA	0042744	biological_process	hydrogen peroxide catabolic process
AAA	0043177	molecular_function	organic acid binding
AAA	0046872	molecular_function	metal ion binding
AAA	0070062	cellular_component	extracellular exosome
AAA	0071682	cellular_component	endocytic vesicle lumen
AAA	0072562	cellular_component	blood microparticle
AAA	0098869	biological_process	cellular oxidant detoxification
BBB	0004601	molecular_function	peroxidase activity
BBB	0005344	molecular_function	oxygen carrier activity
BBB	0005515	molecular_function	protein binding
BBB	0005576	cellular_component	extracellular region
BBB	0005615	cellular_component	extracellular space
BBB	0005829	cellular_component	cytosol
BBB	0005833	cellular_component	hemoglobin complex
BBB	0008217	biological_process	regulation of blood pressure
BBB	0015670	biological_process	carbon dioxide transport
BBB	0015671	biological_process	oxygen transport
BBB	0019825	molecular_function	oxygen binding
BBB	0020037	molecular_function	heme binding
BBB	0030185	biological_process	nitric oxide transport
BBB	0030492	molecular_function	hemoglobin binding
BBB	0031720	molecular_function	haptoglobin binding
BBB	0031721	molecular_function	hemoglobin alpha binding
BBB	0031838	cellular_component	haptoglobin-hemoglobin complex
BBB	0042542	biological_process	response to hydrogen peroxide
BBB	0042744	biological_process	hydrogen peroxide catabolic process
BBB	0043177	molecular_function	organic acid binding
BBB	0045429	biological_process	positive regulation of nitric oxide biosynthetic process
BBB	0046872	molecular_function	metal ion binding
BBB	0070062	cellular_component	extracellular exosome
BBB	0070293	biological_process	renal absorption
BBB	0070527	biological_process	platelet aggregation
BBB	0071682	cellular_component	endocytic vesicle lumen
BBB	0072562	cellular_component	blood microparticle
BBB	0097746	biological_process	blood vessel diameter maintenance
BBB	0098869	biological_process	cellular oxidant detoxification
BBB	1904724	cellular_component	tertiary granule lumen
BBB	1904813	cellular_component	ficolin-1-rich granule lumen
CCC	0004601	molecular_function	peroxidase activity
CCC	0005344	molecular_function	oxygen carrier activity
CCC	0005506	molecular_function	iron ion binding
CCC	0005515	molecular_function	protein binding
CCC	0005576	cellular_component	extracellular region
CCC	0005615	cellular_component	extracellular space
CCC	0005829	cellular_component	cytosol
CCC	0005833	cellular_component	hemoglobin complex
CCC	0015670	biological_process	carbon dioxide transport
CCC	0015671	biological_process	oxygen transport
CCC	0016020	cellular_component	membrane
CCC	0019825	molecular_function	oxygen binding
CCC	0020037	molecular_function	heme binding
CCC	0030185	biological_process	nitric oxide transport
CCC	0031720	molecular_function	haptoglobin binding
CCC	0031838	cellular_component	haptoglobin-hemoglobin complex
CCC	0042542	biological_process	response to hydrogen peroxide
CCC	0042744	biological_process	hydrogen peroxide catabolic process
CCC	0043177	molecular_function	organic acid binding
CCC	0046872	molecular_function	metal ion binding
CCC	0070062	cellular_component	extracellular exosome
CCC	0071682	cellular_component	endocytic vesicle lumen
CCC	0072562	cellular_component	blood microparticle
CCC	0098869	biological_process	cellular oxidant detoxification
DDD	0004601	molecular_function	peroxidase activity
DDD	0005344	molecular_function	oxygen carrier activity
DDD	0005515	molecular_function	protein binding
DDD	0005576	cellular_component	extracellular region
DDD	0005615	cellular_component	extracellular space
DDD	0005829	cellular_component	cytosol
DDD	0005833	cellular_component	hemoglobin complex
DDD	0008217	biological_process	regulation of blood pressure
DDD	0015670	biological_process	carbon dioxide transport
DDD	0015671	biological_process	oxygen transport
DDD	0019825	molecular_function	oxygen binding
DDD	0020037	molecular_function	heme binding
DDD	0030185	biological_process	nitric oxide transport
DDD	0030492	molecular_function	hemoglobin binding
DDD	0031720	molecular_function	haptoglobin binding
DDD	0031721	molecular_function	hemoglobin alpha binding
DDD	0031838	cellular_component	haptoglobin-hemoglobin complex
DDD	0042542	biological_process	response to hydrogen peroxide
DDD	0042744	biological_process	hydrogen peroxide catabolic process
DDD	0043177	molecular_function	organic acid binding
DDD	0045429	biological_process	positive regulation of nitric oxide biosynthetic process
DDD	0046872	molecular_function	metal ion binding
DDD	0070062	cellular_component	extracellular exosome
DDD	0070293	biological_process	renal absorption
DDD	0070527	biological_process	platelet aggregation
DDD	0071682	cellular_component	endocytic vesicle lumen
DDD	0072562	cellular_component	blood microparticle
DDD	0097746	biological_process	blood vessel diameter maintenance
DDD	0098869	biological_process	cellular oxidant detoxification
DDD	1904724	cellular_component	tertiary granule lumen
DDD	1904813	cellular_component	ficolin-1-rich granule lumen

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	6
Details	BINDING:

Chain	Residue	Details
BBB	HIS2
BBB	LYS82
BBB	HIS143
DDD	HIS2
DDD	LYS82
DDD	HIS143

---

site_id	SWS_FT_FI2
Number of Residues	2
Details	BINDING: distal binding residue

Chain	Residue	Details
BBB	HIS63
DDD	HIS63

---

site_id	SWS_FT_FI3
Number of Residues	2
Details	BINDING: proximal binding residue

Chain	Residue	Details
BBB	HIS92
AAA	LEU91
AAA	LEU106
AAA	THR108
AAA	VAL121
AAA	SER133
CCC	THR8
CCC	ALA13
CCC	TYR24
CCC	LEU29
CCC	HIS45
DDD	HIS92
CCC	ASP47
CCC	SER52
CCC	VAL55
CCC	GLY59
CCC	LEU91
CCC	LEU106
CCC	THR108
CCC	VAL121
CCC	SER133
AAA	TYR24
AAA	LEU29
AAA	HIS45
AAA	ASP47
AAA	SER52
AAA	VAL55
AAA	GLY59

---

site_id	SWS_FT_FI4
Number of Residues	38
Details	SITE: (Microbial infection) Cleavage; by N.americanus apr-2 => ECO:0000269|PubMed:12552433

Chain	Residue	Details
BBB	GLU7
BBB	GLY74
BBB	THR84
BBB	HIS92
BBB	ARG104
BBB	LEU110
BBB	GLY119
BBB	PHE122
BBB	ALA128
BBB	ALA140
BBB	LYS144
BBB	GLY25
DDD	GLU7
DDD	GLY25
DDD	GLY29
DDD	TYR35
DDD	TRP37
DDD	PHE45
DDD	ASP52
DDD	GLY56
DDD	PHE71
DDD	GLY74
BBB	GLY29
DDD	THR84
DDD	HIS92
DDD	ARG104
DDD	LEU110
DDD	GLY119
DDD	PHE122
DDD	ALA128
DDD	ALA140
DDD	LYS144
BBB	TYR35
BBB	TRP37
BBB	PHE45
BBB	ASP52
BBB	GLY56
BBB	PHE71

---

site_id	SWS_FT_FI5
Number of Residues	6
Details	SITE: Not glycated => ECO:0000269|PubMed:7358733

Chain	Residue	Details
BBB	LYS59
BBB	LYS82
BBB	LYS95
DDD	LYS59
DDD	LYS82
DDD	LYS95

---

site_id	SWS_FT_FI6
Number of Residues	4
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:24275569

Chain	Residue	Details
BBB	SER9
BBB	SER44
DDD	SER9
DDD	SER44
CCC	LYS16
CCC	LYS40

---

site_id	SWS_FT_FI7
Number of Residues	6
Details	MOD_RES: Phosphothreonine => ECO:0007744|PubMed:24275569

Chain	Residue	Details
BBB	THR12
BBB	THR50
BBB	THR87
DDD	THR12
DDD	THR50
DDD	THR87

---

site_id	SWS_FT_FI8
Number of Residues	4
Details	MOD_RES: N6-acetyllysine => ECO:0000269|PubMed:4531009

Chain	Residue	Details
BBB	LYS59
BBB	LYS82
DDD	LYS59
DDD	LYS82

---

site_id	SWS_FT_FI9
Number of Residues	2
Details	MOD_RES: S-nitrosocysteine => ECO:0000269|PubMed:8637569, ECO:0000269|PubMed:9843411

Chain	Residue	Details
BBB	CYS93
DDD	CYS93

---

site_id	SWS_FT_FI10
Number of Residues	2
Details	MOD_RES: N6-acetyllysine; alternate => ECO:0000269|PubMed:4531009

Chain	Residue	Details
BBB	LYS144
DDD	LYS144
AAA	SER131
AAA	SER138
CCC	SER102
CCC	SER124
CCC	SER131
CCC	SER138

---

site_id	SWS_FT_FI11
Number of Residues	8
Details	CARBOHYD: N-linked (Glc) (glycation) lysine => ECO:0000269|PubMed:7358733

Chain	Residue	Details
BBB	LYS8
BBB	LYS17
BBB	LYS66
BBB	LYS120
DDD	LYS8
DDD	LYS17
DDD	LYS66
DDD	LYS120

---

site_id	SWS_FT_FI12
Number of Residues	2
Details	CARBOHYD: N-linked (Glc) (glycation) lysine; alternate => ECO:0000269|PubMed:7358733

Chain	Residue	Details
BBB	LYS144
DDD	LYS144
AAA	LYS40
CCC	LYS7
CCC	LYS16
CCC	LYS40

---

site_id	SWS_FT_FI13
Number of Residues	2
Details	CARBOHYD: N-linked (Glc) (glycation) lysine => ECO:0000269|PubMed:7358733

Chain	Residue	Details
AAA	LYS61
CCC	LYS61

---