7ADC

Transcription termination intermediate complex 3 delta NusG

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0001000	molecular_function	bacterial-type RNA polymerase core enzyme binding
A	0003676	molecular_function	nucleic acid binding
A	0003700	molecular_function	DNA-binding transcription factor activity
A	0003723	molecular_function	RNA binding
A	0005515	molecular_function	protein binding
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0006353	biological_process	DNA-templated transcription termination
A	0008023	cellular_component	transcription elongation factor complex
A	0019904	molecular_function	protein domain specific binding
A	0031554	biological_process	regulation of termination of DNA-templated transcription
A	0031564	biological_process	transcription antitermination
A	0032784	biological_process	regulation of DNA-templated transcription elongation
A	0042254	biological_process	ribosome biogenesis
A	0051259	biological_process	protein complex oligomerization
U	0000345	cellular_component	cytosolic DNA-directed RNA polymerase complex
U	0000428	cellular_component	DNA-directed RNA polymerase complex
U	0003677	molecular_function	DNA binding
U	0003899	molecular_function	DNA-directed RNA polymerase activity
U	0005515	molecular_function	protein binding
U	0005737	cellular_component	cytoplasm
U	0005829	cellular_component	cytosol
U	0006351	biological_process	DNA-templated transcription
U	0006352	biological_process	DNA-templated transcription initiation
U	0006879	biological_process	intracellular iron ion homeostasis
U	0008023	cellular_component	transcription elongation factor complex
U	0009408	biological_process	response to heat
U	0016020	cellular_component	membrane
U	0016740	molecular_function	transferase activity
U	0016779	molecular_function	nucleotidyltransferase activity
U	0031564	biological_process	transcription antitermination
U	0032784	biological_process	regulation of DNA-templated transcription elongation
U	0034062	molecular_function	5'-3' RNA polymerase activity
U	0036460	biological_process	cellular response to cell envelope stress
U	0042128	biological_process	nitrate assimilation
U	0044780	biological_process	bacterial-type flagellum assembly
U	0046983	molecular_function	protein dimerization activity
U	0048870	biological_process	cell motility
U	0071973	biological_process	bacterial-type flagellum-dependent cell motility
U	0090605	biological_process	submerged biofilm formation
U	2000142	biological_process	regulation of DNA-templated transcription initiation
V	0000345	cellular_component	cytosolic DNA-directed RNA polymerase complex
V	0000428	cellular_component	DNA-directed RNA polymerase complex
V	0003677	molecular_function	DNA binding
V	0003899	molecular_function	DNA-directed RNA polymerase activity
V	0005515	molecular_function	protein binding
V	0005737	cellular_component	cytoplasm
V	0005829	cellular_component	cytosol
V	0006351	biological_process	DNA-templated transcription
V	0006352	biological_process	DNA-templated transcription initiation
V	0006879	biological_process	intracellular iron ion homeostasis
V	0008023	cellular_component	transcription elongation factor complex
V	0009408	biological_process	response to heat
V	0016020	cellular_component	membrane
V	0016740	molecular_function	transferase activity
V	0016779	molecular_function	nucleotidyltransferase activity
V	0031564	biological_process	transcription antitermination
V	0032784	biological_process	regulation of DNA-templated transcription elongation
V	0034062	molecular_function	5'-3' RNA polymerase activity
V	0036460	biological_process	cellular response to cell envelope stress
V	0042128	biological_process	nitrate assimilation
V	0044780	biological_process	bacterial-type flagellum assembly
V	0046983	molecular_function	protein dimerization activity
V	0048870	biological_process	cell motility
V	0071973	biological_process	bacterial-type flagellum-dependent cell motility
V	0090605	biological_process	submerged biofilm formation
V	2000142	biological_process	regulation of DNA-templated transcription initiation
W	0000345	cellular_component	cytosolic DNA-directed RNA polymerase complex
W	0000428	cellular_component	DNA-directed RNA polymerase complex
W	0001000	molecular_function	bacterial-type RNA polymerase core enzyme binding
W	0003677	molecular_function	DNA binding
W	0003899	molecular_function	DNA-directed RNA polymerase activity
W	0005829	cellular_component	cytosol
W	0006351	biological_process	DNA-templated transcription
W	0006352	biological_process	DNA-templated transcription initiation
W	0006879	biological_process	intracellular iron ion homeostasis
W	0008023	cellular_component	transcription elongation factor complex
W	0009408	biological_process	response to heat
W	0016740	molecular_function	transferase activity
W	0016779	molecular_function	nucleotidyltransferase activity
W	0030880	cellular_component	RNA polymerase complex
W	0031564	biological_process	transcription antitermination
W	0032784	biological_process	regulation of DNA-templated transcription elongation
W	0034062	molecular_function	5'-3' RNA polymerase activity
W	0036460	biological_process	cellular response to cell envelope stress
W	0042128	biological_process	nitrate assimilation
W	0044780	biological_process	bacterial-type flagellum assembly
W	0048870	biological_process	cell motility
W	0065003	biological_process	protein-containing complex assembly
W	0071973	biological_process	bacterial-type flagellum-dependent cell motility
W	0090605	biological_process	submerged biofilm formation
W	2000142	biological_process	regulation of DNA-templated transcription initiation
X	0000345	cellular_component	cytosolic DNA-directed RNA polymerase complex
X	0000428	cellular_component	DNA-directed RNA polymerase complex
X	0003677	molecular_function	DNA binding
X	0003899	molecular_function	DNA-directed RNA polymerase activity
X	0005515	molecular_function	protein binding
X	0005737	cellular_component	cytoplasm
X	0005829	cellular_component	cytosol
X	0006351	biological_process	DNA-templated transcription
X	0006352	biological_process	DNA-templated transcription initiation
X	0006879	biological_process	intracellular iron ion homeostasis
X	0008023	cellular_component	transcription elongation factor complex
X	0009408	biological_process	response to heat
X	0016020	cellular_component	membrane
X	0016740	molecular_function	transferase activity
X	0016779	molecular_function	nucleotidyltransferase activity
X	0031564	biological_process	transcription antitermination
X	0032549	molecular_function	ribonucleoside binding
X	0032784	biological_process	regulation of DNA-templated transcription elongation
X	0034062	molecular_function	5'-3' RNA polymerase activity
X	0036460	biological_process	cellular response to cell envelope stress
X	0042128	biological_process	nitrate assimilation
X	0044780	biological_process	bacterial-type flagellum assembly
X	0046677	biological_process	response to antibiotic
X	0048870	biological_process	cell motility
X	0071973	biological_process	bacterial-type flagellum-dependent cell motility
X	0090605	biological_process	submerged biofilm formation
X	2000142	biological_process	regulation of DNA-templated transcription initiation
Y	0000287	molecular_function	magnesium ion binding
Y	0000345	cellular_component	cytosolic DNA-directed RNA polymerase complex
Y	0000428	cellular_component	DNA-directed RNA polymerase complex
Y	0003677	molecular_function	DNA binding
Y	0003899	molecular_function	DNA-directed RNA polymerase activity
Y	0005515	molecular_function	protein binding
Y	0005737	cellular_component	cytoplasm
Y	0005829	cellular_component	cytosol
Y	0006351	biological_process	DNA-templated transcription
Y	0006352	biological_process	DNA-templated transcription initiation
Y	0006879	biological_process	intracellular iron ion homeostasis
Y	0008023	cellular_component	transcription elongation factor complex
Y	0008270	molecular_function	zinc ion binding
Y	0009408	biological_process	response to heat
Y	0016020	cellular_component	membrane
Y	0016740	molecular_function	transferase activity
Y	0016779	molecular_function	nucleotidyltransferase activity
Y	0031564	biological_process	transcription antitermination
Y	0032784	biological_process	regulation of DNA-templated transcription elongation
Y	0034062	molecular_function	5'-3' RNA polymerase activity
Y	0036460	biological_process	cellular response to cell envelope stress
Y	0042128	biological_process	nitrate assimilation
Y	0044780	biological_process	bacterial-type flagellum assembly
Y	0046677	biological_process	response to antibiotic
Y	0046872	molecular_function	metal ion binding
Y	0048870	biological_process	cell motility
Y	0071973	biological_process	bacterial-type flagellum-dependent cell motility
Y	0090605	biological_process	submerged biofilm formation
Y	2000142	biological_process	regulation of DNA-templated transcription initiation
a	0000166	molecular_function	nucleotide binding
a	0003676	molecular_function	nucleic acid binding
a	0003723	molecular_function	RNA binding
a	0004386	molecular_function	helicase activity
a	0005515	molecular_function	protein binding
a	0005524	molecular_function	ATP binding
a	0005829	cellular_component	cytosol
a	0006353	biological_process	DNA-templated transcription termination
a	0008186	molecular_function	ATP-dependent activity, acting on RNA
a	0016020	cellular_component	membrane
a	0016787	molecular_function	hydrolase activity
a	0042802	molecular_function	identical protein binding
b	0000166	molecular_function	nucleotide binding
b	0003676	molecular_function	nucleic acid binding
b	0003723	molecular_function	RNA binding
b	0004386	molecular_function	helicase activity
b	0005515	molecular_function	protein binding
b	0005524	molecular_function	ATP binding
b	0005829	cellular_component	cytosol
b	0006353	biological_process	DNA-templated transcription termination
b	0008186	molecular_function	ATP-dependent activity, acting on RNA
b	0016020	cellular_component	membrane
b	0016787	molecular_function	hydrolase activity
b	0042802	molecular_function	identical protein binding
c	0000166	molecular_function	nucleotide binding
c	0003676	molecular_function	nucleic acid binding
c	0003723	molecular_function	RNA binding
c	0004386	molecular_function	helicase activity
c	0005515	molecular_function	protein binding
c	0005524	molecular_function	ATP binding
c	0005829	cellular_component	cytosol
c	0006353	biological_process	DNA-templated transcription termination
c	0008186	molecular_function	ATP-dependent activity, acting on RNA
c	0016020	cellular_component	membrane
c	0016787	molecular_function	hydrolase activity
c	0042802	molecular_function	identical protein binding
d	0000166	molecular_function	nucleotide binding
d	0003676	molecular_function	nucleic acid binding
d	0003723	molecular_function	RNA binding
d	0004386	molecular_function	helicase activity
d	0005515	molecular_function	protein binding
d	0005524	molecular_function	ATP binding
d	0005829	cellular_component	cytosol
d	0006353	biological_process	DNA-templated transcription termination
d	0008186	molecular_function	ATP-dependent activity, acting on RNA
d	0016020	cellular_component	membrane
d	0016787	molecular_function	hydrolase activity
d	0042802	molecular_function	identical protein binding
e	0000166	molecular_function	nucleotide binding
e	0003676	molecular_function	nucleic acid binding
e	0003723	molecular_function	RNA binding
e	0004386	molecular_function	helicase activity
e	0005515	molecular_function	protein binding
e	0005524	molecular_function	ATP binding
e	0005829	cellular_component	cytosol
e	0006353	biological_process	DNA-templated transcription termination
e	0008186	molecular_function	ATP-dependent activity, acting on RNA
e	0016020	cellular_component	membrane
e	0016787	molecular_function	hydrolase activity
e	0042802	molecular_function	identical protein binding
f	0000166	molecular_function	nucleotide binding
f	0003676	molecular_function	nucleic acid binding
f	0003723	molecular_function	RNA binding
f	0004386	molecular_function	helicase activity
f	0005515	molecular_function	protein binding
f	0005524	molecular_function	ATP binding
f	0005829	cellular_component	cytosol
f	0006353	biological_process	DNA-templated transcription termination
f	0008186	molecular_function	ATP-dependent activity, acting on RNA
f	0016020	cellular_component	membrane
f	0016787	molecular_function	hydrolase activity
f	0042802	molecular_function	identical protein binding

Functional Information from PROSITE/UniProt

site_id	PS01166
Number of Residues	13
Details	RNA_POL_BETA RNA polymerases beta chain signature. GdKMAGrHGNKGV

Chain	Residue	Details
X	GLY1063-VAL1075

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	450
Details	Domain: {"description":"Rho RNA-BD","evidences":[{"source":"PROSITE-ProRule","id":"PRU01203","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	54
Details	Region: {"description":"RNA-binding 1"}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	24
Details	Region: {"description":"RNA-binding 2"}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	30
Details	Binding site: {"evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	36
Details	Binding site: {}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	6
Details	Site: {"description":"RNA-binding 2"}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	65
Details	Domain: {"description":"S1 motif","evidences":[{"source":"HAMAP-Rule","id":"MF_00945","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	63
Details	Domain: {"description":"KH 1","evidences":[{"source":"HAMAP-Rule","id":"MF_00945","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI9
Number of Residues	66
Details	Domain: {"description":"KH 2","evidences":[{"source":"HAMAP-Rule","id":"MF_00945","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI10
Number of Residues	50
Details	Repeat: {"description":"1"}

Chain

Residue

Details

---

site_id	SWS_FT_FI11
Number of Residues	50
Details	Repeat: {"description":"2"}

Chain

Residue

Details

---

site_id	SWS_FT_FI12
Number of Residues	136
Details	Region: {"description":"N-terminal domain (NTD) interacts with RNAP","evidences":[{"source":"PubMed","id":"21922055","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI13
Number of Residues	81
Details	Region: {"description":"Acidic repeat 1 (AR1)","evidences":[{"source":"PubMed","id":"21922055","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI14
Number of Residues	125
Details	Region: {"description":"2 X 51 AA approximate repeats"}

Chain

Residue

Details

---

site_id	SWS_FT_FI15
Number of Residues	68
Details	Region: {"description":"Acidic repeat 2 (AR2), required for interaction with SuhB, interacts with RNAP subunit alpha (rpoA), NusG","evidences":[{"source":"PubMed","id":"31020314","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"31127279","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"21922055","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI16
Number of Residues	6
Details	Region: {"description":"Required for interaction with Crp at class II promoters"}

Chain

Residue

Details

---

site_id	SWS_FT_FI17
Number of Residues	1
Details	Modified residue: {"description":"ADP-ribosylarginine","evidences":[{"source":"PubMed","id":"4371081","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI18
Number of Residues	1
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"21696463","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI19
Number of Residues	1
Details	Modified residue: {"description":"N6-acetyllysine; by PatZ","evidences":[{"source":"PubMed","id":"21696463","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI20
Number of Residues	2
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"HAMAP-Rule","id":"MF_01321","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI23
Number of Residues	11
Details	Binding site: {"evidences":[{"source":"PubMed","id":"32871103","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4MEX","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4MEY","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI24
Number of Residues	1
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"HAMAP-Rule","id":"MF_01322","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"18723842","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---