7A71
Structure of G132S BlaC from Mycobacterium tuberculosis
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005576 | cellular_component | extracellular region |
| A | 0005886 | cellular_component | plasma membrane |
| A | 0008800 | molecular_function | beta-lactamase activity |
| A | 0016787 | molecular_function | hydrolase activity |
| A | 0017001 | biological_process | antibiotic catabolic process |
| A | 0030655 | biological_process | beta-lactam antibiotic catabolic process |
| A | 0042597 | cellular_component | periplasmic space |
| A | 0046677 | biological_process | response to antibiotic |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 11 |
| Details | binding site for residue TRS A 501 |
| Chain | Residue |
| A | PRO107 |
| A | HOH634 |
| A | HOH644 |
| A | GLN110 |
| A | GLN111 |
| A | THR145 |
| A | ALA146 |
| A | THR149 |
| A | ARG161 |
| A | LEU162 |
| A | ASP163 |
| site_id | AC2 |
| Number of Residues | 6 |
| Details | binding site for residue TRS A 502 |
| Chain | Residue |
| A | ARG38 |
| A | ASN197 |
| A | ARG204 |
| A | TYR241 |
| A | GLY271 |
| A | TYR272 |
| site_id | AC3 |
| Number of Residues | 5 |
| Details | binding site for residue GOL A 503 |
| Chain | Residue |
| A | LEU94 |
| A | THR115 |
| A | GLY116 |
| A | THR118 |
| A | GLN121 |
| site_id | AC4 |
| Number of Residues | 6 |
| Details | binding site for residue GOL A 504 |
| Chain | Residue |
| A | ARG103 |
| A | GLU165 |
| A | GLU166 |
| A | GLU168 |
| A | HOH605 |
| A | HOH735 |
| site_id | AC5 |
| Number of Residues | 9 |
| Details | binding site for residue GOL A 505 |
| Chain | Residue |
| A | MET211 |
| A | ALA212 |
| A | ALA218 |
| A | ARG222 |
| A | VAL231 |
| A | ASP233 |
| A | HOH636 |
| A | HOH703 |
| A | HOH714 |
| site_id | AC6 |
| Number of Residues | 7 |
| Details | binding site for residue GOL A 506 |
| Chain | Residue |
| A | ASP28 |
| A | ASP31 |
| A | ARG32 |
| A | SER154 |
| A | GLN192 |
| A | ALA198 |
| A | HOH625 |
| site_id | AC7 |
| Number of Residues | 7 |
| Details | binding site for residue GOL A 507 |
| Chain | Residue |
| A | THR53 |
| A | THR54 |
| A | ALA55 |
| A | GLU275 |
| A | SO4509 |
| A | HOH650 |
| A | HOH763 |
| site_id | AC8 |
| Number of Residues | 8 |
| Details | binding site for residue SO4 A 508 |
| Chain | Residue |
| A | SER70 |
| A | SER130 |
| A | THR235 |
| A | GLY236 |
| A | THR237 |
| A | HOH616 |
| A | HOH707 |
| A | HOH723 |
| site_id | AC9 |
| Number of Residues | 8 |
| Details | binding site for residue SO4 A 509 |
| Chain | Residue |
| A | ALA55 |
| A | LYS219 |
| A | ARG277 |
| A | GLU278 |
| A | ALA279 |
| A | GOL507 |
| A | HOH673 |
| A | HOH745 |
| site_id | AD1 |
| Number of Residues | 5 |
| Details | binding site for residue SO4 A 510 |
| Chain | Residue |
| A | GLY27 |
| A | HIS82 |
| A | SER154 |
| A | HOH710 |
| A | HOH792 |
Functional Information from PROSITE/UniProt
| site_id | PS00146 |
| Number of Residues | 16 |
| Details | BETA_LACTAMASE_A Beta-lactamase class-A active site. FaFCSTfKaplVAAVL |
| Chain | Residue | Details |
| A | PHE66-LEU81 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI2 |
| Number of Residues | 1 |
| Details | Active site: {"description":"Acyl-ester intermediate","evidences":[{"source":"PubMed","id":"19251630","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"20353175","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"20961112","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 1 |
| Details | Active site: {"description":"Proton acceptor","evidences":[{"source":"PubMed","id":"20353175","evidenceCode":"ECO:0000303"},{"source":"PubMed","id":"20961112","evidenceCode":"ECO:0000303"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 3 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"19251630","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"20353175","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"20961112","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 1 |
| Details | Site: {"description":"Increases nucleophilicity of active site Ser","evidences":[{"source":"PubMed","id":"20353175","evidenceCode":"ECO:0000303"},{"source":"PubMed","id":"20961112","evidenceCode":"ECO:0000303"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 1 |
| Details | Site: {"description":"Functions as a gatekeeper residue that regulates substrate accessibility to the enzyme active site","evidences":[{"source":"PubMed","id":"24023821","evidenceCode":"ECO:0000303"}]} |
| Chain | Residue | Details |
