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7A6Y

Structure of 14-3-3 gamma in complex with DAPK2 peptide stabilized by FC-A

Functional Information from GO Data
ChainGOidnamespacecontents
A0002181biological_processcytoplasmic translation
A0002841biological_processnegative regulation of T cell mediated immune response to tumor cell
A0002842biological_processpositive regulation of T cell mediated immune response to tumor cell
A0003723molecular_functionRNA binding
A0005080molecular_functionprotein kinase C binding
A0005159molecular_functioninsulin-like growth factor receptor binding
A0005515molecular_functionprotein binding
A0005634cellular_componentnucleus
A0005737cellular_componentcytoplasm
A0005739cellular_componentmitochondrion
A0005759cellular_componentmitochondrial matrix
A0005829cellular_componentcytosol
A0005925cellular_componentfocal adhesion
A0006469biological_processnegative regulation of protein kinase activity
A0006605biological_processprotein targeting
A0007165biological_processsignal transduction
A0008104biological_processprotein localization
A0008426molecular_functionprotein kinase C inhibitor activity
A0009966biological_processregulation of signal transduction
A0016020cellular_componentmembrane
A0019904molecular_functionprotein domain specific binding
A0022409biological_processpositive regulation of cell-cell adhesion
A0030971molecular_functionreceptor tyrosine kinase binding
A0031146biological_processSCF-dependent proteasomal ubiquitin-dependent protein catabolic process
A0031669biological_processcellular response to nutrient levels
A0031982cellular_componentvesicle
A0032869biological_processcellular response to insulin stimulus
A0032880biological_processregulation of protein localization
A0034198biological_processcellular response to amino acid starvation
A0038202biological_processTORC1 signaling
A0042149biological_processcellular response to glucose starvation
A0042802molecular_functionidentical protein binding
A0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
A0045202cellular_componentsynapse
A0045664biological_processregulation of neuron differentiation
A0045947biological_processnegative regulation of translational initiation
A0045948biological_processpositive regulation of translational initiation
A0048167biological_processregulation of synaptic plasticity
A0050821biological_processprotein stabilization
A0050868biological_processnegative regulation of T cell activation
A0050870biological_processpositive regulation of T cell activation
A0061462biological_processprotein localization to lysosome
A0070062cellular_componentextracellular exosome
A0085020biological_processprotein K6-linked ubiquitination
A0098793cellular_componentpresynapse
A0140031molecular_functionphosphorylation-dependent protein binding
A0140311molecular_functionprotein sequestering activity
A1904262biological_processnegative regulation of TORC1 signaling
A1904263biological_processpositive regulation of TORC1 signaling
B0002181biological_processcytoplasmic translation
B0002841biological_processnegative regulation of T cell mediated immune response to tumor cell
B0002842biological_processpositive regulation of T cell mediated immune response to tumor cell
B0003723molecular_functionRNA binding
B0005080molecular_functionprotein kinase C binding
B0005159molecular_functioninsulin-like growth factor receptor binding
B0005515molecular_functionprotein binding
B0005634cellular_componentnucleus
B0005737cellular_componentcytoplasm
B0005739cellular_componentmitochondrion
B0005759cellular_componentmitochondrial matrix
B0005829cellular_componentcytosol
B0005925cellular_componentfocal adhesion
B0006469biological_processnegative regulation of protein kinase activity
B0006605biological_processprotein targeting
B0007165biological_processsignal transduction
B0008104biological_processprotein localization
B0008426molecular_functionprotein kinase C inhibitor activity
B0009966biological_processregulation of signal transduction
B0016020cellular_componentmembrane
B0019904molecular_functionprotein domain specific binding
B0022409biological_processpositive regulation of cell-cell adhesion
B0030971molecular_functionreceptor tyrosine kinase binding
B0031146biological_processSCF-dependent proteasomal ubiquitin-dependent protein catabolic process
B0031669biological_processcellular response to nutrient levels
B0031982cellular_componentvesicle
B0032869biological_processcellular response to insulin stimulus
B0032880biological_processregulation of protein localization
B0034198biological_processcellular response to amino acid starvation
B0038202biological_processTORC1 signaling
B0042149biological_processcellular response to glucose starvation
B0042802molecular_functionidentical protein binding
B0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
B0045202cellular_componentsynapse
B0045664biological_processregulation of neuron differentiation
B0045947biological_processnegative regulation of translational initiation
B0045948biological_processpositive regulation of translational initiation
B0048167biological_processregulation of synaptic plasticity
B0050821biological_processprotein stabilization
B0050868biological_processnegative regulation of T cell activation
B0050870biological_processpositive regulation of T cell activation
B0061462biological_processprotein localization to lysosome
B0070062cellular_componentextracellular exosome
B0085020biological_processprotein K6-linked ubiquitination
B0098793cellular_componentpresynapse
B0140031molecular_functionphosphorylation-dependent protein binding
B0140311molecular_functionprotein sequestering activity
B1904262biological_processnegative regulation of TORC1 signaling
B1904263biological_processpositive regulation of TORC1 signaling
C0002181biological_processcytoplasmic translation
C0002841biological_processnegative regulation of T cell mediated immune response to tumor cell
C0002842biological_processpositive regulation of T cell mediated immune response to tumor cell
C0003723molecular_functionRNA binding
C0005080molecular_functionprotein kinase C binding
C0005159molecular_functioninsulin-like growth factor receptor binding
C0005515molecular_functionprotein binding
C0005634cellular_componentnucleus
C0005737cellular_componentcytoplasm
C0005739cellular_componentmitochondrion
C0005759cellular_componentmitochondrial matrix
C0005829cellular_componentcytosol
C0005925cellular_componentfocal adhesion
C0006469biological_processnegative regulation of protein kinase activity
C0006605biological_processprotein targeting
C0007165biological_processsignal transduction
C0008104biological_processprotein localization
C0008426molecular_functionprotein kinase C inhibitor activity
C0009966biological_processregulation of signal transduction
C0016020cellular_componentmembrane
C0019904molecular_functionprotein domain specific binding
C0022409biological_processpositive regulation of cell-cell adhesion
C0030971molecular_functionreceptor tyrosine kinase binding
C0031146biological_processSCF-dependent proteasomal ubiquitin-dependent protein catabolic process
C0031669biological_processcellular response to nutrient levels
C0031982cellular_componentvesicle
C0032869biological_processcellular response to insulin stimulus
C0032880biological_processregulation of protein localization
C0034198biological_processcellular response to amino acid starvation
C0038202biological_processTORC1 signaling
C0042149biological_processcellular response to glucose starvation
C0042802molecular_functionidentical protein binding
C0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
C0045202cellular_componentsynapse
C0045664biological_processregulation of neuron differentiation
C0045947biological_processnegative regulation of translational initiation
C0045948biological_processpositive regulation of translational initiation
C0048167biological_processregulation of synaptic plasticity
C0050821biological_processprotein stabilization
C0050868biological_processnegative regulation of T cell activation
C0050870biological_processpositive regulation of T cell activation
C0061462biological_processprotein localization to lysosome
C0070062cellular_componentextracellular exosome
C0085020biological_processprotein K6-linked ubiquitination
C0098793cellular_componentpresynapse
C0140031molecular_functionphosphorylation-dependent protein binding
C0140311molecular_functionprotein sequestering activity
C1904262biological_processnegative regulation of TORC1 signaling
C1904263biological_processpositive regulation of TORC1 signaling
D0002181biological_processcytoplasmic translation
D0002841biological_processnegative regulation of T cell mediated immune response to tumor cell
D0002842biological_processpositive regulation of T cell mediated immune response to tumor cell
D0003723molecular_functionRNA binding
D0005080molecular_functionprotein kinase C binding
D0005159molecular_functioninsulin-like growth factor receptor binding
D0005515molecular_functionprotein binding
D0005634cellular_componentnucleus
D0005737cellular_componentcytoplasm
D0005739cellular_componentmitochondrion
D0005759cellular_componentmitochondrial matrix
D0005829cellular_componentcytosol
D0005925cellular_componentfocal adhesion
D0006469biological_processnegative regulation of protein kinase activity
D0006605biological_processprotein targeting
D0007165biological_processsignal transduction
D0008104biological_processprotein localization
D0008426molecular_functionprotein kinase C inhibitor activity
D0009966biological_processregulation of signal transduction
D0016020cellular_componentmembrane
D0019904molecular_functionprotein domain specific binding
D0022409biological_processpositive regulation of cell-cell adhesion
D0030971molecular_functionreceptor tyrosine kinase binding
D0031146biological_processSCF-dependent proteasomal ubiquitin-dependent protein catabolic process
D0031669biological_processcellular response to nutrient levels
D0031982cellular_componentvesicle
D0032869biological_processcellular response to insulin stimulus
D0032880biological_processregulation of protein localization
D0034198biological_processcellular response to amino acid starvation
D0038202biological_processTORC1 signaling
D0042149biological_processcellular response to glucose starvation
D0042802molecular_functionidentical protein binding
D0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
D0045202cellular_componentsynapse
D0045664biological_processregulation of neuron differentiation
D0045947biological_processnegative regulation of translational initiation
D0045948biological_processpositive regulation of translational initiation
D0048167biological_processregulation of synaptic plasticity
D0050821biological_processprotein stabilization
D0050868biological_processnegative regulation of T cell activation
D0050870biological_processpositive regulation of T cell activation
D0061462biological_processprotein localization to lysosome
D0070062cellular_componentextracellular exosome
D0085020biological_processprotein K6-linked ubiquitination
D0098793cellular_componentpresynapse
D0140031molecular_functionphosphorylation-dependent protein binding
D0140311molecular_functionprotein sequestering activity
D1904262biological_processnegative regulation of TORC1 signaling
D1904263biological_processpositive regulation of TORC1 signaling
Functional Information from PROSITE/UniProt
site_idPS00796
Number of Residues11
Details1433_1 14-3-3 proteins signature 1. RNLLSVAYKNV
ChainResidueDetails
AARG42-VAL52

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues4
DetailsMOD_RES: Phosphothreonine; by PKB/AKT1 => ECO:0000269|PubMed:26047703
ChainResidueDetails
JTPO369
KTPO369
LTPO369
MTPO369
CARG57
CARG132
DARG57
DARG132

site_idSWS_FT_FI2
Number of Residues4
DetailsMOD_RES: N-acetylmethionine; in 14-3-3 protein gamma; alternate; partial => ECO:0000269|Ref.7
ChainResidueDetails
AMET1
BMET1
CMET1
DMET1

site_idSWS_FT_FI3
Number of Residues4
DetailsMOD_RES: N-acetylvaline; partial => ECO:0000269|PubMed:14534293, ECO:0000269|Ref.7, ECO:0000269|Ref.9, ECO:0007744|PubMed:19413330
ChainResidueDetails
AVAL2
BVAL2
CVAL2
DVAL2

site_idSWS_FT_FI4
Number of Residues4
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163
ChainResidueDetails
ASER71
BSER71
CSER71
DSER71

site_idSWS_FT_FI5
Number of Residues4
DetailsMOD_RES: Phosphotyrosine => ECO:0000250|UniProtKB:P61983
ChainResidueDetails
ATYR133
BTYR133
CTYR133
DTYR133

site_idSWS_FT_FI6
Number of Residues4
DetailsMOD_RES: Phosphothreonine => ECO:0000269|Ref.7
ChainResidueDetails
ATHR145
BTHR145
CTHR145
DTHR145

site_idSWS_FT_FI7
Number of Residues4
DetailsMOD_RES: Phosphoserine => ECO:0000250|UniProtKB:P61983
ChainResidueDetails
ASER215
BSER215
CSER215
DSER215

site_idSWS_FT_FI8
Number of Residues4
DetailsMOD_RES: Phosphothreonine => ECO:0007744|PubMed:24275569
ChainResidueDetails
ATHR234
BTHR234
CTHR234
DTHR234

237735

PDB entries from 2025-06-18

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