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Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

7A5O

Human MUC2 AAs 21-1397

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0070701	cellular_component	mucus layer
B	0070701	cellular_component	mucus layer
C	0070701	cellular_component	mucus layer
D	0070701	cellular_component	mucus layer
E	0070701	cellular_component	mucus layer
F	0070701	cellular_component	mucus layer
G	0070701	cellular_component	mucus layer
H	0070701	cellular_component	mucus layer
I	0070701	cellular_component	mucus layer
J	0070701	cellular_component	mucus layer

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	40
Details	BINDING: BINDING => ECO:0000269\|PubMed:36206754

Chain	Residue	Details
C	HIS277
C	HIS324
D	ARG34
D	GLU156
D	HIS277
D	HIS324
E	ARG34
E	GLU156
E	HIS277
E	HIS324
F	ARG34
F	GLU156
F	HIS277
F	HIS324
G	ARG34
G	GLU156
G	HIS277
G	HIS324
H	ARG34
H	GLU156
H	HIS277
H	HIS324
I	ARG34
I	GLU156
I	HIS277
I	HIS324
J	ARG34
J	GLU156
J	HIS277
J	HIS324
A	HIS277
A	HIS324
B	ARG34
A	ARG34
A	GLU156
B	GLU156
B	HIS277
B	HIS324
C	ARG34
C	GLU156

site_id	SWS_FT_FI2
Number of Residues	20
Details	BINDING: BINDING => ECO:0000269\|PubMed:35377815, ECO:0007744\|PDB:7POV

Chain	Residue	Details
G	ASP403
H	ASP49
H	ASP403
I	ASP49
I	ASP403
J	ASP49
J	ASP403
A	ASP49
A	ASP403
B	ASP49
B	ASP403
C	ASP49
C	ASP403
D	ASP49
D	ASP403
E	ASP49
E	ASP403
F	ASP49
F	ASP403
G	ASP49

site_id	SWS_FT_FI3
Number of Residues	30
Details	BINDING: BINDING => ECO:0000305\|PubMed:36206754

Chain	Residue	Details
A	MET146
A	MET154
A	MET326
B	MET146
B	MET154
B	MET326
C	MET146
C	MET154
C	MET326
D	MET146
D	MET154
D	MET326
E	MET146
E	MET154
E	MET326
F	MET146
F	MET154
F	MET326
G	MET146
G	MET154
G	MET326
H	MET146
H	MET154
H	MET326
I	MET146
I	MET154
I	MET326
J	MET146
J	MET154
J	MET326

site_id	SWS_FT_FI4
Number of Residues	10
Details	BINDING: BINDING => ECO:0000269\|PubMed:33031746, ECO:0007744\|PDB:7A5O

Chain	Residue	Details
A	ASP171
B	ASP171
C	ASP171
D	ASP171
E	ASP171
F	ASP171
G	ASP171
H	ASP171
I	ASP171
J	ASP171

site_id	SWS_FT_FI5
Number of Residues	80
Details	BINDING: BINDING => ECO:0000269\|PubMed:33031746, ECO:0000269\|PubMed:35377815, ECO:0007744\|PDB:7A5O, ECO:0007744\|PDB:7POV

Chain	Residue	Details
A	ASN173
A	LEU175
A	GLU180
A	ASN530
A	ASN532
A	LEU534
A	ASP537
A	ASP538
B	ASN173
B	LEU175
B	GLU180
B	ASN530
B	ASN532
B	LEU534
B	ASP537
B	ASP538
C	ASN173
C	LEU175
C	GLU180
C	ASN530
C	ASN532
C	LEU534
C	ASP537
C	ASP538
D	ASN173
D	LEU175
D	GLU180
D	ASN530
D	ASN532
D	LEU534
D	ASP537
D	ASP538
E	ASN173
E	LEU175
E	GLU180
E	ASN530
E	ASN532
E	LEU534
E	ASP537
E	ASP538
F	ASN173
F	LEU175
F	GLU180
F	ASN530
F	ASN532
F	LEU534
F	ASP537
F	ASP538
G	ASN173
G	LEU175
G	GLU180
G	ASN530
G	ASN532
G	LEU534
G	ASP537
G	ASP538
H	ASN173
H	LEU175
H	GLU180
H	ASN530
H	ASN532
H	LEU534
H	ASP537
H	ASP538
I	ASN173
I	LEU175
I	GLU180
I	ASN530
I	ASN532
I	LEU534
I	ASP537
I	ASP538
J	ASN173
J	LEU175
J	GLU180
J	ASN530
J	ASN532
J	LEU534
J	ASP537
J	ASP538

site_id	SWS_FT_FI6
Number of Residues	10
Details	BINDING: BINDING => ECO:0000269\|PubMed:31310764, ECO:0000269\|PubMed:35377815, ECO:0007744\|PDB:6RBF, ECO:0007744\|PDB:7POV

Chain	Residue	Details
A	ASP872
B	ASP872
C	ASP872
D	ASP872
E	ASP872
F	ASP872
G	ASP872
H	ASP872
I	ASP872
J	ASP872

site_id	SWS_FT_FI7
Number of Residues	50
Details	BINDING: BINDING => ECO:0000269\|PubMed:31310764, ECO:0000269\|PubMed:33031746, ECO:0000269\|PubMed:35377815, ECO:0007744\|PDB:6RBF, ECO:0007744\|PDB:7A5O, ECO:0007744\|PDB:7POV

Chain	Residue	Details
A	ASN994
A	ASP996
A	ARG998
A	ASN1001
A	ASP1002
B	ASN994
B	ASP996
B	ARG998
B	ASN1001
B	ASP1002
C	ASN994
C	ASP996
C	ARG998
C	ASN1001
C	ASP1002
D	ASN994
D	ASP996
D	ARG998
D	ASN1001
D	ASP1002
E	ASN994
E	ASP996
E	ARG998
E	ASN1001
E	ASP1002
F	ASN994
F	ASP996
F	ARG998
F	ASN1001
F	ASP1002
G	ASN994
G	ASP996
G	ARG998
G	ASN1001
G	ASP1002
H	ASN994
H	ASP996
H	ARG998
H	ASN1001
H	ASP1002
I	ASN994
I	ASP996
I	ARG998
I	ASN1001
I	ASP1002
J	ASN994
J	ASP996
J	ARG998
J	ASN1001
J	ASP1002

site_id	SWS_FT_FI8
Number of Residues	100
Details	BINDING: BINDING => ECO:0000269\|PubMed:33031746, ECO:0007744\|PDB:6TM2, ECO:0007744\|PDB:7A5O

Chain	Residue	Details
A	ASN1310
A	ASP1312
A	HIS1313
A	SER1316
A	ASP1319
A	GLY1321
A	ASP1322
A	GLU1324
A	ASP1381
A	TYR1382
B	ASN1310
B	ASP1312
B	HIS1313
B	SER1316
B	ASP1319
B	GLY1321
B	ASP1322
B	GLU1324
B	ASP1381
B	TYR1382
C	ASN1310
C	ASP1312
C	HIS1313
C	SER1316
C	ASP1319
C	GLY1321
C	ASP1322
C	GLU1324
C	ASP1381
C	TYR1382
D	ASN1310
D	ASP1312
D	HIS1313
D	SER1316
D	ASP1319
D	GLY1321
D	ASP1322
D	GLU1324
D	ASP1381
D	TYR1382
E	ASN1310
E	ASP1312
E	HIS1313
E	SER1316
E	ASP1319
E	GLY1321
E	ASP1322
E	GLU1324
E	ASP1381
E	TYR1382
F	ASN1310
F	ASP1312
F	HIS1313
F	SER1316
F	ASP1319
F	GLY1321
F	ASP1322
F	GLU1324
F	ASP1381
F	TYR1382
G	ASN1310
G	ASP1312
G	HIS1313
G	SER1316
G	ASP1319
G	GLY1321
G	ASP1322
G	GLU1324
G	ASP1381
G	TYR1382
H	ASN1310
H	ASP1312
H	HIS1313
H	SER1316
H	ASP1319
H	GLY1321
H	ASP1322
H	GLU1324
H	ASP1381
H	TYR1382
I	ASN1310
I	ASP1312
I	HIS1313
I	SER1316
I	ASP1319
I	GLY1321
I	ASP1322
I	GLU1324
I	ASP1381
I	TYR1382
J	ASN1310
J	ASP1312
J	HIS1313
J	SER1316
J	ASP1319
J	GLY1321
J	ASP1322
J	GLU1324
J	ASP1381
J	TYR1382

site_id	SWS_FT_FI9
Number of Residues	10
Details	MOD_RES: Phosphoserine => ECO:0007744\|PubMed:18669648

Chain	Residue	Details
A	SER21
B	SER21
C	SER21
D	SER21
E	SER21
F	SER21
G	SER21
H	SER21
I	SER21
J	SER21

site_id	SWS_FT_FI10
Number of Residues	20
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269\|PubMed:33031746, ECO:0000269\|PubMed:35377815, ECO:0007744\|PDB:7A5O, ECO:0007744\|PDB:7POV

Chain	Residue	Details
A	ASN163
A	ASN670
B	ASN163
B	ASN670
C	ASN163
C	ASN670
D	ASN163
D	ASN670
E	ASN163
E	ASN670
F	ASN163
F	ASN670
G	ASN163
G	ASN670
H	ASN163
H	ASN670
I	ASN163
I	ASN670
J	ASN163
J	ASN670

site_id	SWS_FT_FI11
Number of Residues	60
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255

Chain	Residue	Details
A	ASN423
A	ASN770
A	ASN1139
A	ASN1215
A	ASN1230
A	ASN1246
B	ASN423
B	ASN770
B	ASN1139
B	ASN1215
B	ASN1230
B	ASN1246
C	ASN423
C	ASN770
C	ASN1139
C	ASN1215
C	ASN1230
C	ASN1246
D	ASN423
D	ASN770
D	ASN1139
D	ASN1215
D	ASN1230
D	ASN1246
E	ASN423
E	ASN770
E	ASN1139
E	ASN1215
E	ASN1230
E	ASN1246
F	ASN423
F	ASN770
F	ASN1139
F	ASN1215
F	ASN1230
F	ASN1246
G	ASN423
G	ASN770
G	ASN1139
G	ASN1215
G	ASN1230
G	ASN1246
H	ASN423
H	ASN770
H	ASN1139
H	ASN1215
H	ASN1230
H	ASN1246
I	ASN423
I	ASN770
I	ASN1139
I	ASN1215
I	ASN1230
I	ASN1246
J	ASN423
J	ASN770
J	ASN1139
J	ASN1215
J	ASN1230
J	ASN1246

site_id	SWS_FT_FI12
Number of Residues	10
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269\|PubMed:31310764, ECO:0007744\|PDB:6RBF

Chain	Residue	Details
A	ASN894
B	ASN894
C	ASN894
D	ASN894
E	ASN894
F	ASN894
G	ASN894
H	ASN894
I	ASN894
J	ASN894

site_id	SWS_FT_FI13
Number of Residues	10
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269\|PubMed:31310764, ECO:0000269\|PubMed:33031746, ECO:0000269\|PubMed:35377815, ECO:0007744\|PDB:6RBF, ECO:0007744\|PDB:7A5O, ECO:0007744\|PDB:7POV

Chain	Residue	Details
A	ASN1154
B	ASN1154
C	ASN1154
D	ASN1154
E	ASN1154
F	ASN1154
G	ASN1154
H	ASN1154
I	ASN1154
J	ASN1154

site_id	SWS_FT_FI14
Number of Residues	120
Details	CARBOHYD: O-linked (GalNAc) threonine => ECO:0000269\|PubMed:33031746

Chain	Residue	Details
A	THR1266
A	THR1267
A	THR1269
A	THR1270
A	THR1272
A	THR1275
A	THR1276
A	THR1281
A	THR1282
A	THR1287
A	THR1293
A	THR1297
B	THR1266
B	THR1267
B	THR1269
B	THR1270
B	THR1272
B	THR1275
B	THR1276
B	THR1281
B	THR1282
B	THR1287
B	THR1293
B	THR1297
C	THR1266
C	THR1267
C	THR1269
C	THR1270
C	THR1272
C	THR1275
C	THR1276
C	THR1281
C	THR1282
C	THR1287
C	THR1293
C	THR1297
D	THR1266
D	THR1267
D	THR1269
D	THR1270
D	THR1272
D	THR1275
D	THR1276
D	THR1281
D	THR1282
D	THR1287
D	THR1293
D	THR1297
E	THR1266
E	THR1267
E	THR1269
E	THR1270
E	THR1272
E	THR1275
E	THR1276
E	THR1281
E	THR1282
E	THR1287
E	THR1293
E	THR1297
F	THR1266
F	THR1267
F	THR1269
F	THR1270
F	THR1272
F	THR1275
F	THR1276
F	THR1281
F	THR1282
F	THR1287
F	THR1293
F	THR1297
G	THR1266
G	THR1267
G	THR1269
G	THR1270
G	THR1272
G	THR1275
G	THR1276
G	THR1281
G	THR1282
G	THR1287
G	THR1293
G	THR1297
H	THR1266
H	THR1267
H	THR1269
H	THR1270
H	THR1272
H	THR1275
H	THR1276
H	THR1281
H	THR1282
H	THR1287
H	THR1293
H	THR1297
I	THR1266
I	THR1267
I	THR1269
I	THR1270
I	THR1272
I	THR1275
I	THR1276
I	THR1281
I	THR1282
I	THR1287
I	THR1293
I	THR1297
J	THR1266
J	THR1267
J	THR1269
J	THR1270
J	THR1272
J	THR1275
J	THR1276
J	THR1281
J	THR1282
J	THR1287
J	THR1293
J	THR1297

site_id	SWS_FT_FI15
Number of Residues	30
Details	CARBOHYD: O-linked (GalNAc) serine => ECO:0000269\|PubMed:33031746

Chain	Residue	Details
A	SER1291
A	SER1292
A	SER1296
B	SER1291
B	SER1292
B	SER1296
C	SER1291
C	SER1292
C	SER1296
D	SER1291
D	SER1292
D	SER1296
E	SER1291
E	SER1292
E	SER1296
F	SER1291
F	SER1292
F	SER1296
G	SER1291
G	SER1292
G	SER1296
H	SER1291
H	SER1292
H	SER1296
I	SER1291
I	SER1292
I	SER1296
J	SER1291
J	SER1292
J	SER1296

222415

PDB entries from 2024-07-10

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