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7A3F

Crystal structure of apo DPP9

Functional Information from GO Data
ChainGOidnamespacecontents
A0004177molecular_functionaminopeptidase activity
A0005515molecular_functionprotein binding
A0005634cellular_componentnucleus
A0005737cellular_componentcytoplasm
A0005829cellular_componentcytosol
A0005874cellular_componentmicrotubule
A0006508biological_processproteolysis
A0008236molecular_functionserine-type peptidase activity
A0008239molecular_functiondipeptidyl-peptidase activity
A0031252cellular_componentcell leading edge
A0042802molecular_functionidentical protein binding
A0043069biological_processnegative regulation of programmed cell death
A0070269biological_processpyroptosis
B0004177molecular_functionaminopeptidase activity
B0005515molecular_functionprotein binding
B0005634cellular_componentnucleus
B0005737cellular_componentcytoplasm
B0005829cellular_componentcytosol
B0005874cellular_componentmicrotubule
B0006508biological_processproteolysis
B0008236molecular_functionserine-type peptidase activity
B0008239molecular_functiondipeptidyl-peptidase activity
B0031252cellular_componentcell leading edge
B0042802molecular_functionidentical protein binding
B0043069biological_processnegative regulation of programmed cell death
B0070269biological_processpyroptosis
C0004177molecular_functionaminopeptidase activity
C0005515molecular_functionprotein binding
C0005634cellular_componentnucleus
C0005737cellular_componentcytoplasm
C0005829cellular_componentcytosol
C0005874cellular_componentmicrotubule
C0006508biological_processproteolysis
C0008236molecular_functionserine-type peptidase activity
C0008239molecular_functiondipeptidyl-peptidase activity
C0031252cellular_componentcell leading edge
C0042802molecular_functionidentical protein binding
C0043069biological_processnegative regulation of programmed cell death
C0070269biological_processpyroptosis
D0004177molecular_functionaminopeptidase activity
D0005515molecular_functionprotein binding
D0005634cellular_componentnucleus
D0005737cellular_componentcytoplasm
D0005829cellular_componentcytosol
D0005874cellular_componentmicrotubule
D0006508biological_processproteolysis
D0008236molecular_functionserine-type peptidase activity
D0008239molecular_functiondipeptidyl-peptidase activity
D0031252cellular_componentcell leading edge
D0042802molecular_functionidentical protein binding
D0043069biological_processnegative regulation of programmed cell death
D0070269biological_processpyroptosis
Functional Information from PDB Data
site_idAC1
Number of Residues6
Detailsbinding site for residue PO4 B 901
ChainResidue
BTYR644
BSER730
BTYR731
BVAL756
BTYR762
BTYR766

site_idAC2
Number of Residues5
Detailsbinding site for residue GOL B 902
ChainResidue
BLYS480
BGLU486
BTYR413
BGLU414
BASN445

site_idAC3
Number of Residues5
Detailsbinding site for residue PO4 A 901
ChainResidue
ATYR644
ASER730
ATYR731
ATYR762
ATYR766

site_idAC4
Number of Residues4
Detailsbinding site for residue GOL A 902
ChainResidue
AASN312
APRO313
AILE315
AGLU350

site_idAC5
Number of Residues4
Detailsbinding site for residue PO4 C 901
ChainResidue
CTYR644
CSER730
CTYR762
CTYR766

site_idAC6
Number of Residues5
Detailsbinding site for residue PO4 D 901
ChainResidue
DTYR644
DSER730
DTYR731
DTYR762
DTYR766

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues4
DetailsACT_SITE: Charge relay system => ECO:0000305|PubMed:30291141
ChainResidueDetails
DSER730
BSER730
ASER730
CSER730

site_idSWS_FT_FI2
Number of Residues8
DetailsACT_SITE: Charge relay system => ECO:0000250|UniProtKB:Q6V1X1
ChainResidueDetails
BHIS840
AASP808
AHIS840
CASP808
CHIS840
DASP808
DHIS840
BASP808

site_idSWS_FT_FI3
Number of Residues4
DetailsBINDING: covalent => ECO:0000269|PubMed:33731932, ECO:0000269|PubMed:34019797, ECO:0007744|PDB:6X6C, ECO:0007744|PDB:7JN7
ChainResidueDetails
BSER730
ASER730
CSER730
DSER730

site_idSWS_FT_FI4
Number of Residues4
DetailsMOD_RES: N-acetylalanine => ECO:0007744|PubMed:19413330
ChainResidueDetails
BALA2
AALA2
CALA2
DALA2

221051

PDB entries from 2024-06-12

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