7A1Z

Crystal structure of human protein kinase CK2alpha' (CSNK2A2 gene product) in complex with the ATP-competitive inhibitor 6-bromo-5-chloro-1H-triazolo[4,5-b]pyridine

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000785	cellular_component	chromatin
A	0001669	cellular_component	acrosomal vesicle
A	0004672	molecular_function	protein kinase activity
A	0004674	molecular_function	protein serine/threonine kinase activity
A	0005515	molecular_function	protein binding
A	0005524	molecular_function	ATP binding
A	0005634	cellular_component	nucleus
A	0005654	cellular_component	nucleoplasm
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0005956	cellular_component	protein kinase CK2 complex
A	0006302	biological_process	double-strand break repair
A	0006468	biological_process	protein phosphorylation
A	0006915	biological_process	apoptotic process
A	0007283	biological_process	spermatogenesis
A	0016055	biological_process	Wnt signaling pathway
A	0021987	biological_process	cerebral cortex development
A	0031519	cellular_component	PcG protein complex
A	0032435	biological_process	negative regulation of proteasomal ubiquitin-dependent protein catabolic process
A	0051726	biological_process	regulation of cell cycle
A	0097421	biological_process	liver regeneration
A	0106310	molecular_function	protein serine kinase activity
A	1901524	biological_process	regulation of mitophagy
A	1903955	biological_process	positive regulation of protein targeting to mitochondrion
A	1905818	biological_process	regulation of chromosome separation
A	2001234	biological_process	negative regulation of apoptotic signaling pathway

Functional Information from PDB Data

site_id	AC1
Number of Residues	9
Details	binding site for residue QWN A 401

Chain	Residue
A	LYS69
A	ILE96
A	PHE114
A	GLU115
A	MET164
A	ILE175
A	ASP176
A	HOH540
A	HOH607

---

site_id	AC2
Number of Residues	2
Details	binding site for residue CL A 402

Chain	Residue
A	ARG156
A	ASN190

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site_id	AC3
Number of Residues	8
Details	binding site for residue EDO A 403

Chain	Residue
A	PHE136
A	GLU140
A	VAL328
A	GLU331
A	GLN332
A	HOH502
A	HOH514
A	HOH722

---

site_id	AC4
Number of Residues	9
Details	binding site for residue EDO A 404

Chain	Residue
A	TYR13
A	ALA14
A	GLU15
A	VAL16
A	LEU19
A	HOH674
A	HOH680
A	HOH682
A	HOH712

---

site_id	AC5
Number of Residues	3
Details	binding site for residue EDO A 405

Chain	Residue
A	TRP34
A	GLY35
A	LYS108

---

site_id	AC6
Number of Residues	6
Details	binding site for residue EDO A 406

Chain	Residue
A	PHE122
A	LYS123
A	TYR197
A	PHE198
A	GLU231
A	HOH646

---

site_id	AC7
Number of Residues	5
Details	binding site for residue EDO A 407

Chain	Residue
A	TYR308
A	ASP309
A	GLN312
A	HOH523
A	HOH716

---

site_id	AC8
Number of Residues	8
Details	binding site for residue EDO A 408

Chain	Residue
A	LEU42
A	PHE55
A	GLU318
A	GLU321
A	HIS322
A	HOH507
A	HOH508
A	HOH515

---

Functional Information from PROSITE/UniProt

site_id	PS00107
Number of Residues	24
Details	PROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. LGRGKYSEVFeAinitnner..........VVVK

Chain	Residue	Details
A	LEU46-LYS69

---

site_id	PS00108
Number of Residues	13
Details	PROTEIN_KINASE_ST Serine/Threonine protein kinases active-site signature. ImHrDVKphNVMI

Chain	Residue	Details
A	ILE153-ILE165

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	ACT_SITE: Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027

Chain	Residue	Details
A	ASP157

---

site_id	SWS_FT_FI2
Number of Residues	2
Details	BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00159

Chain	Residue	Details
A	LEU46
A	LYS69

---

site_id	SWS_FT_FI3
Number of Residues	1
Details	MOD_RES: Phosphotyrosine => ECO:0007744|PubMed:19369195

Chain	Residue	Details
A	TYR13

---

site_id	SWS_FT_FI4
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:18691976, ECO:0007744|PubMed:19369195, ECO:0007744|PubMed:23186163

Chain	Residue	Details
A	SER18

---

site_id	SWS_FT_FI5
Number of Residues	2
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:18691976, ECO:0007744|PubMed:19369195

Chain	Residue	Details
A	SER21
A	SER288

---

site_id	SWS_FT_FI6
Number of Residues	1
Details	MOD_RES: N6-acetyllysine => ECO:0007744|PubMed:19608861

Chain	Residue	Details
A	LYS97

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