7A0E
The Crystal Structure of Bovine Thrombin in complex with Hirudin (C6U/C14U) at 1.9 Angstroms Resolution
This is a non-PDB format compatible entry.
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| HHH | 0004252 | molecular_function | serine-type endopeptidase activity |
| HHH | 0005509 | molecular_function | calcium ion binding |
| HHH | 0006508 | biological_process | proteolysis |
| HHH | 0007596 | biological_process | blood coagulation |
| III | 0004857 | molecular_function | enzyme inhibitor activity |
| III | 0004867 | molecular_function | serine-type endopeptidase inhibitor activity |
| III | 0005576 | cellular_component | extracellular region |
| III | 0005615 | cellular_component | extracellular space |
| III | 0030414 | molecular_function | peptidase inhibitor activity |
| III | 0035821 | biological_process | modulation of process of another organism |
| III | 0090729 | molecular_function | toxin activity |
| LLL | 0004252 | molecular_function | serine-type endopeptidase activity |
| LLL | 0005576 | cellular_component | extracellular region |
| LLL | 0006508 | biological_process | proteolysis |
| LLL | 0007596 | biological_process | blood coagulation |
Functional Information from PROSITE/UniProt
| site_id | PS00134 |
| Number of Residues | 6 |
| Details | TRYPSIN_HIS Serine proteases, trypsin family, histidine active site. LTAAHC |
| Chain | Residue | Details |
| HHH | LEU39-CYS44 |
| site_id | PS00135 |
| Number of Residues | 12 |
| Details | TRYPSIN_SER Serine proteases, trypsin family, serine active site. DAceGDSGGPFV |
| Chain | Residue | Details |
| HHH | ASP199-VAL210 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 22 |
| Details | Region: {"description":"High affinity receptor-binding region which is also known as the TP508 peptide","evidences":[{"evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 3 |
| Details | Active site: {"description":"Charge relay system"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 1 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"book","publicationDate":"1975","firstPage":"25","lastPage":"46","publisher":"Leiden University Press","address":"Leiden","bookName":"Boerhaave symposium on prothrombin and related coagulation factors","editors":["Hemker H.C.","Veltkamp J.J."],"authors":["Magnusson S.","Sottrup-Jensen L.","Petersen T.E.","Claeys H."]}}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | Region: {"description":"Interaction with thrombin active site"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"Sulfotyrosine","evidences":[{"source":"PubMed","id":"17685615","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"8251938","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 1 |
| Details | Glycosylation: {"description":"O-linked (GalNAc...) threonine","evidences":[{"evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
