6ZYA
Extended human uromodulin filament core at 3.5 A resolution
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005509 | molecular_function | calcium ion binding |
Functional Information from PROSITE/UniProt
| site_id | PS00010 |
| Number of Residues | 12 |
| Details | ASX_HYDROXYL Aspartic acid and asparagine hydroxylation site. CvNtpgsFsCvC |
| Chain | Residue | Details |
| A | CYS83-CYS94 | |
| A | CYS126-CYS137 |
| site_id | PS00682 |
| Number of Residues | 41 |
| Details | ZP_1 ZP domain signature. VgtmldggDlsrFaLlMtnCYaTPss..NaTdplkyfIIqdr.C |
| Chain | Residue | Details |
| A | VAL487-CYS527 |
| site_id | PS01186 |
| Number of Residues | 14 |
| Details | EGF_2 EGF-like domain signature 2. CtCqeGFtgdglt..C |
| Chain | Residue | Details |
| A | CYS50-CYS63 | |
| A | CYS92-CYS106 | |
| A | CYS135-CYS150 |
| site_id | PS01187 |
| Number of Residues | 28 |
| Details | EGF_CA Calcium-binding EGF-like domain signature. DlDECaipgahn.......Csanss..CvNtpgsFsC |
| Chain | Residue | Details |
| A | ASP65-CYS92 | |
| A | ASP108-CYS135 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 95 |
| Details | Region: {"description":"ZP-N","evidences":[{"source":"PubMed","id":"26811476","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"32815518","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"33196145","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"35273390","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 23 |
| Details | Region: {"description":"Flexible ZP-N/ZP-C linker; important for secretion and polymerization into filaments","evidences":[{"source":"PubMed","id":"26811476","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 11 |
| Details | Region: {"description":"Internal hydrophobic patch (IHP)","evidences":[{"source":"PubMed","id":"26811476","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"32815518","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"33196145","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 1 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) (complex) asparagine","evidences":[{"source":"PubMed","id":"22171320","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"32616672","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"32815518","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"33196145","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"35273390","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6TQK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6TQL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6ZS5","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6ZYA","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7PFP","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 1 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) (high mannose) asparagine; alternate","evidences":[{"source":"PubMed","id":"32616672","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"32815518","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"33196145","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6TQK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6TQL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6ZS5","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6ZYA","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7PFP","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
