6ZST
Thioredoxin glutathione reductase from Schistosoma mansoni in complex with 3-(3-methoxyquinoxalin-2-yl)propanoic acid
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0000166 | molecular_function | nucleotide binding |
A | 0004362 | molecular_function | glutathione-disulfide reductase (NADPH) activity |
A | 0004791 | molecular_function | thioredoxin-disulfide reductase (NADPH) activity |
A | 0005739 | cellular_component | mitochondrion |
A | 0005829 | cellular_component | cytosol |
A | 0006749 | biological_process | glutathione metabolic process |
A | 0016491 | molecular_function | oxidoreductase activity |
A | 0016668 | molecular_function | oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor |
A | 0034599 | biological_process | cellular response to oxidative stress |
A | 0045454 | biological_process | cell redox homeostasis |
A | 0046872 | molecular_function | metal ion binding |
A | 0050660 | molecular_function | flavin adenine dinucleotide binding |
A | 0098869 | biological_process | cellular oxidant detoxification |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 38 |
Details | binding site for residue FAD A 601 |
Chain | Residue |
A | ILE113 |
A | CYS154 |
A | VAL157 |
A | GLY158 |
A | CYS159 |
A | LYS162 |
A | ALA226 |
A | LYS227 |
A | GLY228 |
A | ALA256 |
A | THR257 |
A | GLY114 |
A | GLY258 |
A | TYR296 |
A | VAL297 |
A | ARG393 |
A | GLY432 |
A | ASP433 |
A | GLN440 |
A | LEU441 |
A | THR442 |
A | PRO443 |
A | GLY116 |
A | HIS571 |
A | HOH769 |
A | HOH806 |
A | HOH845 |
A | HOH877 |
A | HOH885 |
A | HOH895 |
A | HOH927 |
A | HOH959 |
A | SER117 |
A | GLY118 |
A | ASP137 |
A | TYR138 |
A | GLY152 |
A | THR153 |
site_id | AC2 |
Number of Residues | 5 |
Details | binding site for residue K A 602 |
Chain | Residue |
A | GLN447 |
A | ASP565 |
A | THR567 |
A | THR579 |
A | HOH932 |
site_id | AC3 |
Number of Residues | 2 |
Details | binding site for residue PEG A 603 |
Chain | Residue |
A | TYR108 |
A | PGE606 |
site_id | AC4 |
Number of Residues | 3 |
Details | binding site for residue PGE A 604 |
Chain | Residue |
A | ASP488 |
A | LYS492 |
A | HOH729 |
site_id | AC5 |
Number of Residues | 11 |
Details | binding site for residue PGE A 605 |
Chain | Residue |
A | GLN327 |
A | LYS331 |
A | HIS502 |
A | ASN504 |
A | TYR521 |
A | LYS585 |
A | PRO591 |
A | HOH727 |
A | HOH846 |
A | HOH972 |
A | HOH1107 |
site_id | AC6 |
Number of Residues | 6 |
Details | binding site for residue PGE A 606 |
Chain | Residue |
A | TYR223 |
A | ASN225 |
A | ILE238 |
A | PEG603 |
A | HOH825 |
A | HOH1026 |
site_id | AC7 |
Number of Residues | 4 |
Details | binding site for residue EY7 A 607 |
Chain | Residue |
A | ARG317 |
A | SER318 |
A | ARG322 |
A | HOH925 |
Functional Information from PROSITE/UniProt
site_id | PS00076 |
Number of Residues | 11 |
Details | PYRIDINE_REDOX_1 Pyridine nucleotide-disulphide oxidoreductases class-I active site. GGtCVnvGCIP |
Chain | Residue | Details |
A | GLY151-PRO161 |
site_id | PS00194 |
Number of Residues | 19 |
Details | THIOREDOXIN_1 Thioredoxin family active site. VIlFSktTCPYCKkVkdvL |
Chain | Residue | Details |
A | VAL20-LEU38 |
site_id | PS00195 |
Number of Residues | 17 |
Details | GLUTAREDOXIN_1 Glutaredoxin active site. LFskttCPYCkkVkdvL |
Chain | Residue | Details |
A | LEU22-LEU38 |