6ZSP

Human serine racemase bound to ATP and malonate.

This is a non-PDB format compatible entry.

Functional Information from GO Data

Chain	GOid	namespace	contents
AAA	0000166	molecular_function	nucleotide binding
AAA	0000287	molecular_function	magnesium ion binding
AAA	0003824	molecular_function	catalytic activity
AAA	0003941	molecular_function	L-serine ammonia-lyase activity
AAA	0005509	molecular_function	calcium ion binding
AAA	0005515	molecular_function	protein binding
AAA	0005524	molecular_function	ATP binding
AAA	0005737	cellular_component	cytoplasm
AAA	0005829	cellular_component	cytosol
AAA	0006520	biological_process	amino acid metabolic process
AAA	0006563	biological_process	L-serine metabolic process
AAA	0008721	molecular_function	D-serine ammonia-lyase activity
AAA	0009410	biological_process	response to xenobiotic stimulus
AAA	0016594	molecular_function	glycine binding
AAA	0016829	molecular_function	lyase activity
AAA	0016853	molecular_function	isomerase activity
AAA	0018114	molecular_function	threonine racemase activity
AAA	0030165	molecular_function	PDZ domain binding
AAA	0030170	molecular_function	pyridoxal phosphate binding
AAA	0030378	molecular_function	serine racemase activity
AAA	0032496	biological_process	response to lipopolysaccharide
AAA	0042802	molecular_function	identical protein binding
AAA	0042803	molecular_function	protein homodimerization activity
AAA	0042866	biological_process	pyruvate biosynthetic process
AAA	0043025	cellular_component	neuronal cell body
AAA	0045177	cellular_component	apical part of cell
AAA	0046872	molecular_function	metal ion binding
AAA	0070178	biological_process	D-serine metabolic process
AAA	0070179	biological_process	D-serine biosynthetic process
AAA	1901986	biological_process	response to ketamine
BBB	0000166	molecular_function	nucleotide binding
BBB	0000287	molecular_function	magnesium ion binding
BBB	0003824	molecular_function	catalytic activity
BBB	0003941	molecular_function	L-serine ammonia-lyase activity
BBB	0005509	molecular_function	calcium ion binding
BBB	0005515	molecular_function	protein binding
BBB	0005524	molecular_function	ATP binding
BBB	0005737	cellular_component	cytoplasm
BBB	0005829	cellular_component	cytosol
BBB	0006520	biological_process	amino acid metabolic process
BBB	0006563	biological_process	L-serine metabolic process
BBB	0008721	molecular_function	D-serine ammonia-lyase activity
BBB	0009410	biological_process	response to xenobiotic stimulus
BBB	0016594	molecular_function	glycine binding
BBB	0016829	molecular_function	lyase activity
BBB	0016853	molecular_function	isomerase activity
BBB	0018114	molecular_function	threonine racemase activity
BBB	0030165	molecular_function	PDZ domain binding
BBB	0030170	molecular_function	pyridoxal phosphate binding
BBB	0030378	molecular_function	serine racemase activity
BBB	0032496	biological_process	response to lipopolysaccharide
BBB	0042802	molecular_function	identical protein binding
BBB	0042803	molecular_function	protein homodimerization activity
BBB	0042866	biological_process	pyruvate biosynthetic process
BBB	0043025	cellular_component	neuronal cell body
BBB	0045177	cellular_component	apical part of cell
BBB	0046872	molecular_function	metal ion binding
BBB	0070178	biological_process	D-serine metabolic process
BBB	0070179	biological_process	D-serine biosynthetic process
BBB	1901986	biological_process	response to ketamine

Functional Information from PROSITE/UniProt

site_id	PS00165
Number of Residues	14
Details	DEHYDRATASE_SER_THR Serine/threonine dehydratases pyridoxal-phosphate attachment site. Elfqk.TGSFKIRGA

Chain	Residue	Details
AAA	GLU47-ALA60

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	Active site: {"description":"Proton acceptor","evidences":[{"source":"UniProtKB","id":"O59791","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"35410329","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7NBH","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	18
Details	Binding site: {"evidences":[{"source":"PubMed","id":"35410329","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6ZSP","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"35410329","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7NBD","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	14
Details	Binding site: {"evidences":[{"source":"PubMed","id":"20106978","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"29277459","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"35410329","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3L6B","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5X2L","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7NBC","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7NBD","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7NBF","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7NBG","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"UniProtKB","id":"Q76EQ0","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"32039887","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"35410329","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6SLH","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6ZUJ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7NBD","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"20106978","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"35410329","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3L6B","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3L6R","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI9
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"PubMed","id":"20106978","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3L6B","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3L6R","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI10
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"35410329","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7NBC","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7NBD","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7NBF","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7NBG","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7NBH","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI11
Number of Residues	2
Details	Modified residue: {"description":"N6-(pyridoxal phosphate)lysine","evidences":[{"source":"PubMed","id":"20106978","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"29277459","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"35410329","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3L6B","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5X2L","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7NBC","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7NBD","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7NBF","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7NBG","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI12
Number of Residues	2
Details	Modified residue: {"description":"S-nitrosocysteine","evidences":[{"source":"UniProtKB","id":"Q9QZX7","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---