6ZRI

Crystal structure of OXA-10loop24 in complex with meropenem

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0008658	molecular_function	penicillin binding
A	0008800	molecular_function	beta-lactamase activity
A	0016787	molecular_function	hydrolase activity
A	0017001	biological_process	antibiotic catabolic process
A	0046677	biological_process	response to antibiotic
A	0046872	molecular_function	metal ion binding
A	0071555	biological_process	cell wall organization
B	0008658	molecular_function	penicillin binding
B	0008800	molecular_function	beta-lactamase activity
B	0016787	molecular_function	hydrolase activity
B	0017001	biological_process	antibiotic catabolic process
B	0046677	biological_process	response to antibiotic
B	0046872	molecular_function	metal ion binding
B	0071555	biological_process	cell wall organization
C	0008658	molecular_function	penicillin binding
C	0008800	molecular_function	beta-lactamase activity
C	0016787	molecular_function	hydrolase activity
C	0017001	biological_process	antibiotic catabolic process
C	0046677	biological_process	response to antibiotic
C	0046872	molecular_function	metal ion binding
C	0071555	biological_process	cell wall organization
D	0008658	molecular_function	penicillin binding
D	0008800	molecular_function	beta-lactamase activity
D	0016787	molecular_function	hydrolase activity
D	0017001	biological_process	antibiotic catabolic process
D	0046677	biological_process	response to antibiotic
D	0046872	molecular_function	metal ion binding
D	0071555	biological_process	cell wall organization

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	binding site for residue EDO A 301

Chain	Residue
A	ASN143
A	ASN145
A	HOH448
A	HOH503

---

site_id	AC2
Number of Residues	4
Details	binding site for residue EDO A 302

Chain	Residue
A	GLU224
A	GLU226
A	HOH511
C	THR107

---

site_id	AC3
Number of Residues	20
Details	binding site for residue DWZ A 303

Chain	Residue
A	SER67
A	KCX70
A	MET99
A	GLN101
A	TRP102
A	GLN113
A	VAL114
A	SER115
A	VAL117
A	LEU155
A	GLY207
A	TRP208
A	ARG247
A	HOH416
A	HOH437
A	HOH449
A	HOH469
A	HOH491
C	PRO198
A	ALA66

---

site_id	AC4
Number of Residues	2
Details	binding site for residue EDO A 304

Chain	Residue
A	SER181
A	LYS182

---

site_id	AC5
Number of Residues	3
Details	binding site for residue EDO A 305

Chain	Residue
A	ARG160
A	HOH470
A	HOH522

---

site_id	AC6
Number of Residues	4
Details	binding site for residue EDO B 301

Chain	Residue
B	ALA98
B	HOH417
B	HOH585
B	HOH586

---

site_id	AC7
Number of Residues	5
Details	binding site for residue EDO B 303

Chain	Residue
A	LYS84
A	ASN85
A	HOH429
B	THR23
B	GLU24

---

site_id	AC8
Number of Residues	4
Details	binding site for residue EDO B 304

Chain	Residue
B	ASN143
B	ASN145
B	HOH449
B	HOH474

---

site_id	AC9
Number of Residues	3
Details	binding site for residue EDO B 305

Chain	Residue
B	ARG160
B	HOH476
B	HOH531

---

site_id	AD1
Number of Residues	9
Details	binding site for residue EDO C 301

Chain	Residue
C	ALA36
C	VAL37
C	ASN38
C	HOH402
D	ASP55
D	ALA57
D	ARG58
D	LYS61
D	HOH410

---

site_id	AD2
Number of Residues	7
Details	binding site for residue EDO D 301

Chain	Residue
B	THR107
B	HOH468
D	GLU199
D	GLU224
D	GLU226
D	HOH445
D	HOH553

---

site_id	AD3
Number of Residues	4
Details	binding site for residue EDO D 302

Chain	Residue
C	THR252
D	ARG131
D	TYR135
D	HOH429

---

site_id	AD4
Number of Residues	3
Details	binding site for residue EDO D 304

Chain	Residue
D	LYS84
D	ASN85
D	HOH493

---

site_id	AD5
Number of Residues	25
Details	binding site for Di-peptide DWZ B 302 and SER B 67

Chain	Residue
B	PRO65
B	ALA66
B	THR68
B	PHE69
B	KCX70
B	MET99
B	GLN101
B	TRP102
B	GLN113
B	VAL114
B	SER115
B	VAL117
B	LEU155
B	LYS205
B	THR206
B	GLY207
B	TRP208
B	MET210
B	ARG247
B	HOH408
B	HOH416
B	HOH443
B	HOH523
B	HOH525
D	PRO198

---

site_id	AD6
Number of Residues	23
Details	binding site for Di-peptide DWZ C 302 and SER C 67

Chain	Residue
C	THR68
C	PHE69
C	KCX70
C	MET99
C	GLN101
C	VAL114
C	SER115
C	VAL117
C	LEU155
C	LYS205
C	THR206
C	GLY207
C	TRP208
C	MET210
C	LEU244
C	ARG247
C	HOH401
C	HOH418
C	HOH436
C	HOH493
C	HOH545
C	PRO65
C	ALA66

---

site_id	AD7
Number of Residues	21
Details	binding site for Di-peptide DWZ D 303 and SER D 67

Chain	Residue
D	PRO65
D	ALA66
D	THR68
D	PHE69
D	KCX70
D	MET99
D	GLN101
D	VAL114
D	SER115
D	VAL117
D	LEU155
D	LYS205
D	THR206
D	GLY207
D	TRP208
D	MET210
D	ARG247
D	HOH407
D	HOH422
D	HOH489
D	HOH522

---

Functional Information from PROSITE/UniProt

site_id	PS00337
Number of Residues	11
Details	BETA_LACTAMASE_D Beta-lactamase class-D active site. PaSTFKIPnAI

Chain	Residue	Details
A	PRO65-ILE75

---