6ZOV

ENTEROPEPTIDASE IN COMPLEX WITH COMPOUND 6

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004252	molecular_function	serine-type endopeptidase activity
A	0006508	biological_process	proteolysis
B	0004252	molecular_function	serine-type endopeptidase activity
B	0006508	biological_process	proteolysis
C	0004252	molecular_function	serine-type endopeptidase activity
C	0006508	biological_process	proteolysis
D	0004252	molecular_function	serine-type endopeptidase activity
D	0006508	biological_process	proteolysis

Functional Information from PDB Data

site_id	AC1
Number of Residues	11
Details	binding site for residue GBS A 301

Chain	Residue
A	ASP181
A	GLY218
A	HOH429
A	SER182
A	CYS183
A	GLN184
A	GLY185
A	SER187
A	GLY208
A	GLU210
A	CYS211

---

site_id	AC2
Number of Residues	4
Details	binding site for residue PGE A 302

Chain	Residue
A	TRP229
A	SER232
A	PHE233
B	TYR44

---

site_id	AC3
Number of Residues	7
Details	binding site for residue EDO B 302

Chain	Residue
B	HIS83
B	ASN91
B	ASN169
B	ARG225
B	PHE226
B	HOH474
B	HOH486

---

site_id	AC4
Number of Residues	4
Details	binding site for residue EDO B 304

Chain	Residue
B	GLY10
B	ALA11
B	TRP199
B	HOH443

---

site_id	AC5
Number of Residues	2
Details	binding site for residue EDO B 305

Chain	Residue
B	ASP22
B	LEU65

---

site_id	AC6
Number of Residues	4
Details	binding site for residue EDO D 302

Chain	Residue
D	VAL71
D	ARG73
D	ASN103
D	HOH512

---

site_id	AC7
Number of Residues	3
Details	binding site for residue EDO D 303

Chain	Residue
D	ASN154
D	HOH413
D	HOH444

---

site_id	AC8
Number of Residues	6
Details	binding site for residue GOL D 304

Chain	Residue
D	HIS83
D	ASN91
D	ASN169
D	ARG225
D	PHE226
D	HOH430

---

site_id	AC9
Number of Residues	18
Details	binding site for Di-peptide GBS B 301 and SER B 187

Chain	Residue
B	CYS26
B	GLY27
B	HIS41
B	CYS42
B	ASP181
B	SER182
B	GLN184
B	GLY185
B	ASP186
B	GLY188
B	GLY189
B	THR205
B	SER206
B	GLY208
B	GLU210
B	CYS211
B	GLY218
B	HOH480

---

site_id	AD1
Number of Residues	19
Details	binding site for Di-peptide GBS C 301 and SER C 187

Chain	Residue
C	CYS26
C	GLY27
C	HIS41
C	CYS42
C	ASP181
C	SER182
C	GLN184
C	GLY185
C	ASP186
C	GLY188
C	GLY189
C	THR205
C	SER206
C	GLY208
C	GLU210
C	CYS211
C	GLY218
C	HOH417
C	HOH450

---

site_id	AD2
Number of Residues	19
Details	binding site for Di-peptide GBS D 301 and SER D 187

Chain	Residue
D	CYS26
D	GLY27
D	HIS41
D	CYS42
D	ASP181
D	SER182
D	GLN184
D	GLY185
D	ASP186
D	GLY188
D	GLY189
D	THR205
D	SER206
D	GLY208
D	GLU210
D	CYS211
D	GLY218
D	HOH419
D	HOH469

---

Functional Information from PROSITE/UniProt

site_id	PS00134
Number of Residues	6
Details	TRYPSIN_HIS Serine proteases, trypsin family, histidine active site. VSAAHC

Chain	Residue	Details
A	VAL37-CYS42

---

site_id	PS00135
Number of Residues	12
Details	TRYPSIN_SER Serine proteases, trypsin family, serine active site. DScqGDSGGPLM

Chain	Residue	Details
A	ASP181-MET192

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	12
Details	Active site: {"description":"Charge relay system","evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	16
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	468
Details	Domain: {"description":"Peptidase S1","evidences":[{"source":"PROSITE-ProRule","id":"PRU00274","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

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