6ZOH
3-Formylrifamycin SV binding to the access pocket of AcrB-G619P_G621P L and T protomers
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005515 | molecular_function | protein binding |
| A | 0005886 | cellular_component | plasma membrane |
| A | 0009410 | biological_process | response to xenobiotic stimulus |
| A | 0009636 | biological_process | response to toxic substance |
| A | 0015125 | molecular_function | bile acid transmembrane transporter activity |
| A | 0015562 | molecular_function | efflux transmembrane transporter activity |
| A | 0015567 | molecular_function | alkane transmembrane transporter activity |
| A | 0015721 | biological_process | bile acid and bile salt transport |
| A | 0015895 | biological_process | alkane transport |
| A | 0015908 | biological_process | fatty acid transport |
| A | 0016020 | cellular_component | membrane |
| A | 0022857 | molecular_function | transmembrane transporter activity |
| A | 0042802 | molecular_function | identical protein binding |
| A | 0042908 | biological_process | xenobiotic transport |
| A | 0042910 | molecular_function | xenobiotic transmembrane transporter activity |
| A | 0042930 | biological_process | enterobactin transport |
| A | 0042931 | molecular_function | enterobactin transmembrane transporter activity |
| A | 0046677 | biological_process | response to antibiotic |
| A | 0055085 | biological_process | transmembrane transport |
| A | 0098567 | cellular_component | periplasmic side of plasma membrane |
| A | 0140330 | biological_process | xenobiotic detoxification by transmembrane export across the cell outer membrane |
| A | 1990281 | cellular_component | efflux pump complex |
| B | 0005515 | molecular_function | protein binding |
| B | 0005886 | cellular_component | plasma membrane |
| B | 0009410 | biological_process | response to xenobiotic stimulus |
| B | 0009636 | biological_process | response to toxic substance |
| B | 0015125 | molecular_function | bile acid transmembrane transporter activity |
| B | 0015562 | molecular_function | efflux transmembrane transporter activity |
| B | 0015567 | molecular_function | alkane transmembrane transporter activity |
| B | 0015721 | biological_process | bile acid and bile salt transport |
| B | 0015895 | biological_process | alkane transport |
| B | 0015908 | biological_process | fatty acid transport |
| B | 0016020 | cellular_component | membrane |
| B | 0022857 | molecular_function | transmembrane transporter activity |
| B | 0042802 | molecular_function | identical protein binding |
| B | 0042908 | biological_process | xenobiotic transport |
| B | 0042910 | molecular_function | xenobiotic transmembrane transporter activity |
| B | 0042930 | biological_process | enterobactin transport |
| B | 0042931 | molecular_function | enterobactin transmembrane transporter activity |
| B | 0046677 | biological_process | response to antibiotic |
| B | 0055085 | biological_process | transmembrane transport |
| B | 0098567 | cellular_component | periplasmic side of plasma membrane |
| B | 0140330 | biological_process | xenobiotic detoxification by transmembrane export across the cell outer membrane |
| B | 1990281 | cellular_component | efflux pump complex |
| C | 0005515 | molecular_function | protein binding |
| C | 0005886 | cellular_component | plasma membrane |
| C | 0009410 | biological_process | response to xenobiotic stimulus |
| C | 0009636 | biological_process | response to toxic substance |
| C | 0015125 | molecular_function | bile acid transmembrane transporter activity |
| C | 0015562 | molecular_function | efflux transmembrane transporter activity |
| C | 0015567 | molecular_function | alkane transmembrane transporter activity |
| C | 0015721 | biological_process | bile acid and bile salt transport |
| C | 0015895 | biological_process | alkane transport |
| C | 0015908 | biological_process | fatty acid transport |
| C | 0016020 | cellular_component | membrane |
| C | 0022857 | molecular_function | transmembrane transporter activity |
| C | 0042802 | molecular_function | identical protein binding |
| C | 0042908 | biological_process | xenobiotic transport |
| C | 0042910 | molecular_function | xenobiotic transmembrane transporter activity |
| C | 0042930 | biological_process | enterobactin transport |
| C | 0042931 | molecular_function | enterobactin transmembrane transporter activity |
| C | 0046677 | biological_process | response to antibiotic |
| C | 0055085 | biological_process | transmembrane transport |
| C | 0098567 | cellular_component | periplasmic side of plasma membrane |
| C | 0140330 | biological_process | xenobiotic detoxification by transmembrane export across the cell outer membrane |
| C | 1990281 | cellular_component | efflux pump complex |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 6 |
| Details | binding site for residue LMT A 1201 |
| Chain | Residue |
| A | SER530 |
| A | ARG536 |
| A | SER537 |
| A | ARG540 |
| A | TYR541 |
| A | PHE1020 |
| site_id | AC2 |
| Number of Residues | 3 |
| Details | binding site for residue LMT A 1202 |
| Chain | Residue |
| A | LEU28 |
| A | LYS29 |
| A | ILE348 |
| site_id | AC3 |
| Number of Residues | 5 |
| Details | binding site for residue EDO A 1203 |
| Chain | Residue |
| A | GLU130 |
| A | LYS163 |
| A | SER167 |
| A | ASP174 |
| A | VAL175 |
| site_id | AC4 |
| Number of Residues | 5 |
| Details | binding site for residue GOL A 1204 |
| Chain | Residue |
| A | PRO50 |
| A | ARG185 |
| A | GLU273 |
| A | GLY755 |
| A | MET774 |
| site_id | AC5 |
| Number of Residues | 1 |
| Details | binding site for residue D12 A 1205 |
| Chain | Residue |
| A | ALA457 |
| site_id | AC6 |
| Number of Residues | 1 |
| Details | binding site for residue DDQ A 1206 |
| Chain | Residue |
| A | GLY511 |
| site_id | AC7 |
| Number of Residues | 3 |
| Details | binding site for residue EDO A 1207 |
| Chain | Residue |
| A | ASP745 |
| A | ARG792 |
| A | ALA793 |
| site_id | AC8 |
| Number of Residues | 1 |
| Details | binding site for residue D12 A 1208 |
| Chain | Residue |
| B | TRP895 |
| site_id | AC9 |
| Number of Residues | 4 |
| Details | binding site for residue EDO A 1209 |
| Chain | Residue |
| A | LYS55 |
| A | GLY691 |
| A | HIS692 |
| C | GLY766 |
| site_id | AD1 |
| Number of Residues | 9 |
| Details | binding site for residue 3YI A 1210 |
| Chain | Residue |
| A | GLN577 |
| A | PHE617 |
| A | ARG620 |
| A | PHE664 |
| A | PHE666 |
| A | ARG717 |
| A | ASN719 |
| A | ARG815 |
| A | LEU828 |
| site_id | AD2 |
| Number of Residues | 7 |
| Details | binding site for residue LMT A 1211 |
| Chain | Residue |
| A | GLY440 |
| A | GLY444 |
| A | CYS887 |
| A | ALA890 |
| A | LEU891 |
| C | ARG8 |
| C | D121104 |
| site_id | AD3 |
| Number of Residues | 6 |
| Details | binding site for residue EDO A 1212 |
| Chain | Residue |
| A | LEU782 |
| C | GLN229 |
| C | LEU230 |
| C | HIS596 |
| C | LYS601 |
| E | HOH204 |
| site_id | AD4 |
| Number of Residues | 7 |
| Details | binding site for residue LMT B 1101 |
| Chain | Residue |
| B | SER530 |
| B | ARG536 |
| B | SER537 |
| B | ARG540 |
| B | TYR541 |
| B | VAL1016 |
| D | ASP72 |
| site_id | AD5 |
| Number of Residues | 3 |
| Details | binding site for residue EDO B 1102 |
| Chain | Residue |
| B | GLU192 |
| B | ARG263 |
| B | ASP264 |
| site_id | AD6 |
| Number of Residues | 6 |
| Details | binding site for residue GOL B 1103 |
| Chain | Residue |
| A | ARG168 |
| A | GLU309 |
| B | LEU75 |
| B | MET76 |
| B | ASN820 |
| B | HOH1210 |
| site_id | AD7 |
| Number of Residues | 4 |
| Details | binding site for residue EDO B 1104 |
| Chain | Residue |
| B | PHE727 |
| B | PRO783 |
| B | SER805 |
| B | SER807 |
| site_id | AD8 |
| Number of Residues | 9 |
| Details | binding site for residue DDR B 1105 |
| Chain | Residue |
| B | VAL452 |
| B | MET456 |
| B | TYR467 |
| B | TYR877 |
| B | SER880 |
| B | VAL884 |
| B | VAL905 |
| B | GLN928 |
| B | LEU932 |
| site_id | AD9 |
| Number of Residues | 2 |
| Details | binding site for residue DDQ B 1106 |
| Chain | Residue |
| A | PHE11 |
| B | GLY440 |
| site_id | AE1 |
| Number of Residues | 7 |
| Details | binding site for residue 3YI B 1107 |
| Chain | Residue |
| B | MET575 |
| B | PHE617 |
| B | ARG620 |
| B | ARG717 |
| B | ASN719 |
| B | ARG815 |
| B | LEU828 |
| site_id | AE2 |
| Number of Residues | 8 |
| Details | binding site for residue PTY C 1101 |
| Chain | Residue |
| B | TRP13 |
| C | ILE882 |
| C | PHE885 |
| C | SER894 |
| C | TRP895 |
| C | SER896 |
| C | LYS950 |
| C | ARG1030 |
| site_id | AE3 |
| Number of Residues | 8 |
| Details | binding site for residue LMT C 1102 |
| Chain | Residue |
| C | ARG536 |
| C | SER537 |
| C | ARG540 |
| C | TYR541 |
| C | LEU544 |
| C | ILE548 |
| C | SER530 |
| C | GLY533 |
| site_id | AE4 |
| Number of Residues | 1 |
| Details | binding site for residue D12 C 1103 |
| Chain | Residue |
| C | PHE458 |
| site_id | AE5 |
| Number of Residues | 2 |
| Details | binding site for residue D12 C 1104 |
| Chain | Residue |
| A | LMT1211 |
| C | MET1 |
| site_id | AE6 |
| Number of Residues | 2 |
| Details | binding site for residue D10 C 1105 |
| Chain | Residue |
| C | PHE556 |
| C | ILE935 |
| site_id | AE7 |
| Number of Residues | 3 |
| Details | binding site for residue LPX C 1106 |
| Chain | Residue |
| C | GLY387 |
| C | PHE388 |
| C | ARG468 |
| site_id | AE8 |
| Number of Residues | 5 |
| Details | binding site for residue EDO C 1107 |
| Chain | Residue |
| C | GLY675 |
| C | THR676 |
| C | ALA677 |
| C | ASN719 |
| C | GLU826 |
| site_id | AE9 |
| Number of Residues | 1 |
| Details | binding site for residue EDO C 1108 |
| Chain | Residue |
| C | GLN89 |
| site_id | AF1 |
| Number of Residues | 2 |
| Details | binding site for residue EDO C 1109 |
| Chain | Residue |
| A | GLN67 |
| C | LYS770 |
| site_id | AF2 |
| Number of Residues | 2 |
| Details | binding site for residue EDO C 1110 |
| Chain | Residue |
| C | GLU339 |
| C | LYS342 |
| site_id | AF3 |
| Number of Residues | 5 |
| Details | binding site for residue GOL C 1112 |
| Chain | Residue |
| C | ARG185 |
| C | GLU273 |
| C | GLY755 |
| C | GLY756 |
| C | MET774 |
| site_id | AF4 |
| Number of Residues | 3 |
| Details | binding site for residue LMT C 1113 |
| Chain | Residue |
| C | LYS29 |
| C | ALA384 |
| C | ALA385 |
| site_id | AF5 |
| Number of Residues | 2 |
| Details | binding site for residue LMT C 1114 |
| Chain | Residue |
| C | GLY511 |
| C | PHE512 |
| site_id | AF6 |
| Number of Residues | 1 |
| Details | binding site for residue HEX C 1115 |
| Chain | Residue |
| C | SER530 |
| site_id | AF7 |
| Number of Residues | 4 |
| Details | binding site for residue GOL C 1116 |
| Chain | Residue |
| C | GLU593 |
| C | HIS596 |
| C | TYR597 |
| C | LYS601 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 372 |
| Details | Topological domain: {"description":"Cytoplasmic","evidences":[{"source":"PubMed","id":"15919996","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 54 |
| Details | Transmembrane: {"description":"Helical; Name=1"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 1932 |
| Details | Topological domain: {"description":"Periplasmic","evidences":[{"source":"PubMed","id":"15919996","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 57 |
| Details | Transmembrane: {"description":"Helical; Name=2"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 57 |
| Details | Transmembrane: {"description":"Helical; Name=3"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 63 |
| Details | Transmembrane: {"description":"Helical; Name=4"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 54 |
| Details | Transmembrane: {"description":"Helical; Name=5"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 72 |
| Details | Transmembrane: {"description":"Helical; Name=6"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI9 |
| Number of Residues | 48 |
| Details | Transmembrane: {"description":"Helical; Name=7"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI10 |
| Number of Residues | 48 |
| Details | Transmembrane: {"description":"Helical; Name=8"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI11 |
| Number of Residues | 57 |
| Details | Transmembrane: {"description":"Helical; Name=9"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI12 |
| Number of Residues | 54 |
| Details | Transmembrane: {"description":"Helical; Name=10"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI13 |
| Number of Residues | 57 |
| Details | Transmembrane: {"description":"Helical; Name=11"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI14 |
| Number of Residues | 57 |
| Details | Transmembrane: {"description":"Helical; Name=12"} |
| Chain | Residue | Details |
