Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

6ZOH

3-Formylrifamycin SV binding to the access pocket of AcrB-G619P_G621P L and T protomers

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005515	molecular_function	protein binding
A	0005886	cellular_component	plasma membrane
A	0009410	biological_process	response to xenobiotic stimulus
A	0009636	biological_process	response to toxic substance
A	0015125	molecular_function	bile acid transmembrane transporter activity
A	0015562	molecular_function	efflux transmembrane transporter activity
A	0015567	molecular_function	alkane transmembrane transporter activity
A	0015721	biological_process	bile acid and bile salt transport
A	0015895	biological_process	alkane transport
A	0015908	biological_process	fatty acid transport
A	0016020	cellular_component	membrane
A	0022857	molecular_function	transmembrane transporter activity
A	0042802	molecular_function	identical protein binding
A	0042908	biological_process	xenobiotic transport
A	0042910	molecular_function	xenobiotic transmembrane transporter activity
A	0042930	biological_process	enterobactin transport
A	0042931	molecular_function	enterobactin transmembrane transporter activity
A	0046677	biological_process	response to antibiotic
A	0055085	biological_process	transmembrane transport
A	0098567	cellular_component	periplasmic side of plasma membrane
A	0140330	biological_process	xenobiotic detoxification by transmembrane export across the cell outer membrane
A	1990281	cellular_component	efflux pump complex
B	0005515	molecular_function	protein binding
B	0005886	cellular_component	plasma membrane
B	0009410	biological_process	response to xenobiotic stimulus
B	0009636	biological_process	response to toxic substance
B	0015125	molecular_function	bile acid transmembrane transporter activity
B	0015562	molecular_function	efflux transmembrane transporter activity
B	0015567	molecular_function	alkane transmembrane transporter activity
B	0015721	biological_process	bile acid and bile salt transport
B	0015895	biological_process	alkane transport
B	0015908	biological_process	fatty acid transport
B	0016020	cellular_component	membrane
B	0022857	molecular_function	transmembrane transporter activity
B	0042802	molecular_function	identical protein binding
B	0042908	biological_process	xenobiotic transport
B	0042910	molecular_function	xenobiotic transmembrane transporter activity
B	0042930	biological_process	enterobactin transport
B	0042931	molecular_function	enterobactin transmembrane transporter activity
B	0046677	biological_process	response to antibiotic
B	0055085	biological_process	transmembrane transport
B	0098567	cellular_component	periplasmic side of plasma membrane
B	0140330	biological_process	xenobiotic detoxification by transmembrane export across the cell outer membrane
B	1990281	cellular_component	efflux pump complex
C	0005515	molecular_function	protein binding
C	0005886	cellular_component	plasma membrane
C	0009410	biological_process	response to xenobiotic stimulus
C	0009636	biological_process	response to toxic substance
C	0015125	molecular_function	bile acid transmembrane transporter activity
C	0015562	molecular_function	efflux transmembrane transporter activity
C	0015567	molecular_function	alkane transmembrane transporter activity
C	0015721	biological_process	bile acid and bile salt transport
C	0015895	biological_process	alkane transport
C	0015908	biological_process	fatty acid transport
C	0016020	cellular_component	membrane
C	0022857	molecular_function	transmembrane transporter activity
C	0042802	molecular_function	identical protein binding
C	0042908	biological_process	xenobiotic transport
C	0042910	molecular_function	xenobiotic transmembrane transporter activity
C	0042930	biological_process	enterobactin transport
C	0042931	molecular_function	enterobactin transmembrane transporter activity
C	0046677	biological_process	response to antibiotic
C	0055085	biological_process	transmembrane transport
C	0098567	cellular_component	periplasmic side of plasma membrane
C	0140330	biological_process	xenobiotic detoxification by transmembrane export across the cell outer membrane
C	1990281	cellular_component	efflux pump complex

Functional Information from PDB Data

site_id	AC1
Number of Residues	6
Details	binding site for residue LMT A 1201

Chain	Residue
A	SER530
A	ARG536
A	SER537
A	ARG540
A	TYR541
A	PHE1020

site_id	AC2
Number of Residues	3
Details	binding site for residue LMT A 1202

Chain	Residue
A	LEU28
A	LYS29
A	ILE348

site_id	AC3
Number of Residues	5
Details	binding site for residue EDO A 1203

Chain	Residue
A	GLU130
A	LYS163
A	SER167
A	ASP174
A	VAL175

site_id	AC4
Number of Residues	5
Details	binding site for residue GOL A 1204

Chain	Residue
A	PRO50
A	ARG185
A	GLU273
A	GLY755
A	MET774

site_id	AC5
Number of Residues	1
Details	binding site for residue D12 A 1205

Chain	Residue
A	ALA457

site_id	AC6
Number of Residues	1
Details	binding site for residue DDQ A 1206

Chain	Residue
A	GLY511

site_id	AC7
Number of Residues	3
Details	binding site for residue EDO A 1207

Chain	Residue
A	ASP745
A	ARG792
A	ALA793

site_id	AC8
Number of Residues	1
Details	binding site for residue D12 A 1208

Chain	Residue
B	TRP895

site_id	AC9
Number of Residues	4
Details	binding site for residue EDO A 1209

Chain	Residue
A	LYS55
A	GLY691
A	HIS692
C	GLY766

site_id	AD1
Number of Residues	9
Details	binding site for residue 3YI A 1210

Chain	Residue
A	GLN577
A	PHE617
A	ARG620
A	PHE664
A	PHE666
A	ARG717
A	ASN719
A	ARG815
A	LEU828

site_id	AD2
Number of Residues	7
Details	binding site for residue LMT A 1211

Chain	Residue
A	GLY440
A	GLY444
A	CYS887
A	ALA890
A	LEU891
C	ARG8
C	D121104

site_id	AD3
Number of Residues	6
Details	binding site for residue EDO A 1212

Chain	Residue
A	LEU782
C	GLN229
C	LEU230
C	HIS596
C	LYS601
E	HOH204

site_id	AD4
Number of Residues	7
Details	binding site for residue LMT B 1101

Chain	Residue
B	SER530
B	ARG536
B	SER537
B	ARG540
B	TYR541
B	VAL1016
D	ASP72

site_id	AD5
Number of Residues	3
Details	binding site for residue EDO B 1102

Chain	Residue
B	GLU192
B	ARG263
B	ASP264

site_id	AD6
Number of Residues	6
Details	binding site for residue GOL B 1103

Chain	Residue
A	ARG168
A	GLU309
B	LEU75
B	MET76
B	ASN820
B	HOH1210

site_id	AD7
Number of Residues	4
Details	binding site for residue EDO B 1104

Chain	Residue
B	PHE727
B	PRO783
B	SER805
B	SER807

site_id	AD8
Number of Residues	9
Details	binding site for residue DDR B 1105

Chain	Residue
B	VAL452
B	MET456
B	TYR467
B	TYR877
B	SER880
B	VAL884
B	VAL905
B	GLN928
B	LEU932

site_id	AD9
Number of Residues	2
Details	binding site for residue DDQ B 1106

Chain	Residue
A	PHE11
B	GLY440

site_id	AE1
Number of Residues	7
Details	binding site for residue 3YI B 1107

Chain	Residue
B	MET575
B	PHE617
B	ARG620
B	ARG717
B	ASN719
B	ARG815
B	LEU828

site_id	AE2
Number of Residues	8
Details	binding site for residue PTY C 1101

Chain	Residue
B	TRP13
C	ILE882
C	PHE885
C	SER894
C	TRP895
C	SER896
C	LYS950
C	ARG1030

site_id	AE3
Number of Residues	8
Details	binding site for residue LMT C 1102

Chain	Residue
C	ARG536
C	SER537
C	ARG540
C	TYR541
C	LEU544
C	ILE548
C	SER530
C	GLY533

site_id	AE4
Number of Residues	1
Details	binding site for residue D12 C 1103

Chain	Residue
C	PHE458

site_id	AE5
Number of Residues	2
Details	binding site for residue D12 C 1104

Chain	Residue
A	LMT1211
C	MET1

site_id	AE6
Number of Residues	2
Details	binding site for residue D10 C 1105

Chain	Residue
C	PHE556
C	ILE935

site_id	AE7
Number of Residues	3
Details	binding site for residue LPX C 1106

Chain	Residue
C	GLY387
C	PHE388
C	ARG468

site_id	AE8
Number of Residues	5
Details	binding site for residue EDO C 1107

Chain	Residue
C	GLY675
C	THR676
C	ALA677
C	ASN719
C	GLU826

site_id	AE9
Number of Residues	1
Details	binding site for residue EDO C 1108

Chain	Residue
C	GLN89

site_id	AF1
Number of Residues	2
Details	binding site for residue EDO C 1109

Chain	Residue
A	GLN67
C	LYS770

site_id	AF2
Number of Residues	2
Details	binding site for residue EDO C 1110

Chain	Residue
C	GLU339
C	LYS342

site_id	AF3
Number of Residues	5
Details	binding site for residue GOL C 1112

Chain	Residue
C	ARG185
C	GLU273
C	GLY755
C	GLY756
C	MET774

site_id	AF4
Number of Residues	3
Details	binding site for residue LMT C 1113

Chain	Residue
C	LYS29
C	ALA384
C	ALA385

site_id	AF5
Number of Residues	2
Details	binding site for residue LMT C 1114

Chain	Residue
C	GLY511
C	PHE512

site_id	AF6
Number of Residues	1
Details	binding site for residue HEX C 1115

Chain	Residue
C	SER530

site_id	AF7
Number of Residues	4
Details	binding site for residue GOL C 1116

Chain	Residue
C	GLU593
C	HIS596
C	TYR597
C	LYS601

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	462
Details	TOPO_DOM: Cytoplasmic => ECO:0000269\|PubMed:15919996

Chain	Residue	Details
A	MET1-PRO9
B	GLU414-ILE438
B	ALA491-THR538
B	ALA889-PRO898
B	LEU944-LEU972
B	ILE1019-HIS1049
C	MET1-PRO9
C	LEU357-THR365
C	GLU414-ILE438
C	ALA491-THR538
C	ALA889-PRO898
A	LEU357-THR365
C	LEU944-LEU972
C	ILE1019-HIS1049
A	GLU414-ILE438
A	ALA491-THR538
A	ALA889-PRO898
A	LEU944-LEU972
A	ILE1019-HIS1049
B	MET1-PRO9
B	LEU357-THR365

site_id	SWS_FT_FI2
Number of Residues	54
Details	TRANSMEM: Helical; Name=1

Chain	Residue	Details
A	ILE10-LEU28
B	ILE10-LEU28
C	ILE10-LEU28

site_id	SWS_FT_FI3
Number of Residues	1932
Details	TOPO_DOM: Periplasmic => ECO:0000269\|PubMed:15919996

Chain	Residue	Details
A	LYS29-SER336
B	PHE556-ASN871
B	ARG919-ASP924
B	THR993-GLY998
C	LYS29-SER336
C	PHE386-ASN391
C	PHE458-ALA465
C	PHE556-ASN871
C	ARG919-ASP924
C	THR993-GLY998
A	PHE386-ASN391
A	PHE458-ALA465
A	PHE556-ASN871
A	ARG919-ASP924
A	THR993-GLY998
B	LYS29-SER336
B	PHE386-ASN391
B	PHE458-ALA465

site_id	SWS_FT_FI4
Number of Residues	57
Details	TRANSMEM: Helical; Name=2

Chain	Residue	Details
A	ILE337-TYR356
B	ILE337-TYR356
C	ILE337-TYR356

site_id	SWS_FT_FI5
Number of Residues	57
Details	TRANSMEM: Helical; Name=3

Chain	Residue	Details
A	LEU366-ALA385
B	LEU366-ALA385
C	LEU366-ALA385

site_id	SWS_FT_FI6
Number of Residues	63
Details	TRANSMEM: Helical; Name=4

Chain	Residue	Details
A	THR392-VAL413
B	THR392-VAL413
C	THR392-VAL413

site_id	SWS_FT_FI7
Number of Residues	54
Details	TRANSMEM: Helical; Name=5

Chain	Residue	Details
A	GLN439-ALA457
B	GLN439-ALA457
C	GLN439-ALA457

site_id	SWS_FT_FI8
Number of Residues	72
Details	TRANSMEM: Helical; Name=6

Chain	Residue	Details
A	ILE466-PRO490
B	ILE466-PRO490
C	ILE466-PRO490

site_id	SWS_FT_FI9
Number of Residues	48
Details	TRANSMEM: Helical; Name=7

Chain	Residue	Details
A	GLY539-LEU555
B	GLY539-LEU555
C	GLY539-LEU555

site_id	SWS_FT_FI10
Number of Residues	48
Details	TRANSMEM: Helical; Name=8

Chain	Residue	Details
A	GLN872-LEU888
B	GLN872-LEU888
C	GLN872-LEU888

site_id	SWS_FT_FI11
Number of Residues	57
Details	TRANSMEM: Helical; Name=9

Chain	Residue	Details
A	PHE899-PHE918
B	PHE899-PHE918
C	PHE899-PHE918

site_id	SWS_FT_FI12
Number of Residues	54
Details	TRANSMEM: Helical; Name=10

Chain	Residue	Details
A	VAL925-ILE943
B	VAL925-ILE943
C	VAL925-ILE943

site_id	SWS_FT_FI13
Number of Residues	57
Details	TRANSMEM: Helical; Name=11

Chain	Residue	Details
A	ARG973-SER992
B	ARG973-SER992
C	ARG973-SER992

site_id	SWS_FT_FI14
Number of Residues	57
Details	TRANSMEM: Helical; Name=12

Chain	Residue	Details
A	ALA999-ALA1018
B	ALA999-ALA1018
C	ALA999-ALA1018

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)