Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

6ZOB

3-Formylrifamycin SV binding to the access pocket of AcrB L protomer

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005515	molecular_function	protein binding
A	0005886	cellular_component	plasma membrane
A	0015562	molecular_function	efflux transmembrane transporter activity
A	0016020	cellular_component	membrane
A	0022857	molecular_function	transmembrane transporter activity
A	0042802	molecular_function	identical protein binding
A	0042908	biological_process	xenobiotic transport
A	0042910	molecular_function	xenobiotic transmembrane transporter activity
A	0055085	biological_process	transmembrane transport
A	0098567	cellular_component	periplasmic side of plasma membrane
A	0140330	biological_process	xenobiotic detoxification by transmembrane export across the cell outer membrane
A	1990281	cellular_component	efflux pump complex
B	0005515	molecular_function	protein binding
B	0005886	cellular_component	plasma membrane
B	0015562	molecular_function	efflux transmembrane transporter activity
B	0016020	cellular_component	membrane
B	0022857	molecular_function	transmembrane transporter activity
B	0042802	molecular_function	identical protein binding
B	0042908	biological_process	xenobiotic transport
B	0042910	molecular_function	xenobiotic transmembrane transporter activity
B	0055085	biological_process	transmembrane transport
B	0098567	cellular_component	periplasmic side of plasma membrane
B	0140330	biological_process	xenobiotic detoxification by transmembrane export across the cell outer membrane
B	1990281	cellular_component	efflux pump complex
C	0005515	molecular_function	protein binding
C	0005886	cellular_component	plasma membrane
C	0015562	molecular_function	efflux transmembrane transporter activity
C	0016020	cellular_component	membrane
C	0022857	molecular_function	transmembrane transporter activity
C	0042802	molecular_function	identical protein binding
C	0042908	biological_process	xenobiotic transport
C	0042910	molecular_function	xenobiotic transmembrane transporter activity
C	0055085	biological_process	transmembrane transport
C	0098567	cellular_component	periplasmic side of plasma membrane
C	0140330	biological_process	xenobiotic detoxification by transmembrane export across the cell outer membrane
C	1990281	cellular_component	efflux pump complex

Functional Information from PDB Data

site_id	AC1
Number of Residues	5
Details	binding site for residue LMT A 1201

Chain	Residue
A	GLY440
A	CYS887
A	ALA890
A	LEU891
C	ARG8

site_id	AC2
Number of Residues	1
Details	binding site for residue LMT A 1202

Chain	Residue
A	LEU28

site_id	AC3
Number of Residues	4
Details	binding site for residue LMT A 1203

Chain	Residue
A	TYR541
A	SER530
A	ARG536
A	ARG540

site_id	AC4
Number of Residues	1
Details	binding site for residue HEX A 1204

Chain	Residue
A	PHE458

site_id	AC5
Number of Residues	6
Details	binding site for residue GOL A 1205

Chain	Residue
A	SER84
A	GLY581
A	THR724
C	GLN218
C	ASN231
C	SER233

site_id	AC6
Number of Residues	1
Details	binding site for residue LMT A 1206

Chain	Residue
A	GLY511

site_id	AC7
Number of Residues	1
Details	binding site for residue ETE A 1207

Chain	Residue
A	GLY957

site_id	AC8
Number of Residues	9
Details	binding site for residue 3YI A 1208

Chain	Residue
A	MET575
A	GLN577
A	PHE617
A	PHE664
A	PHE666
A	ARG717
A	ASN719
A	ARG815
A	LEU828

site_id	AC9
Number of Residues	3
Details	binding site for residue EDO A 1209

Chain	Residue
A	TYR811
E	ARG23
E	ASP44

site_id	AD1
Number of Residues	5
Details	binding site for residue LMT B 1101

Chain	Residue
B	SER530
B	ARG536
B	ARG540
B	TYR541
D	ASP72

site_id	AD2
Number of Residues	6
Details	binding site for residue DDR B 1102

Chain	Residue
B	MET456
B	TYR467
B	TYR877
B	SER880
B	VAL905
B	GLN928

site_id	AD3
Number of Residues	2
Details	binding site for residue DDQ B 1103

Chain	Residue
A	PHE11
B	LEU891

site_id	AD4
Number of Residues	1
Details	binding site for residue OCT B 1104

Chain	Residue
B	ASP301

site_id	AD5
Number of Residues	4
Details	binding site for residue GOL B 1105

Chain	Residue
B	ASN189
B	ARG263
B	ASP264
B	GLU776

site_id	AD6
Number of Residues	7
Details	binding site for residue LMT C 1101

Chain	Residue
C	SER530
C	GLY533
C	ARG536
C	SER537
C	ARG540
C	TYR541
C	PHE1020

site_id	AD7
Number of Residues	6
Details	binding site for residue GOL C 1103

Chain	Residue
A	GLY51
A	GLY755
A	MET774
C	GLN218
C	GLY221
C	THR222

site_id	AD8
Number of Residues	5
Details	binding site for residue GOL D 201

Chain	Residue
D	ASN122
D	ASP143
D	PHE145
D	LYS147
D	ILE152

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	462
Details	TOPO_DOM: Cytoplasmic => ECO:0000269\|PubMed:15919996

Chain	Residue	Details
A	MET1-PRO9
B	GLU414-ILE438
B	ALA491-THR538
B	ALA889-PRO898
B	LEU944-LEU972
B	ILE1019-HIS1049
C	MET1-PRO9
C	LEU357-THR365
C	GLU414-ILE438
C	ALA491-THR538
C	ALA889-PRO898
A	LEU357-THR365
C	LEU944-LEU972
C	ILE1019-HIS1049
A	GLU414-ILE438
A	ALA491-THR538
A	ALA889-PRO898
A	LEU944-LEU972
A	ILE1019-HIS1049
B	MET1-PRO9
B	LEU357-THR365

site_id	SWS_FT_FI2
Number of Residues	54
Details	TRANSMEM: Helical; Name=1

Chain	Residue	Details
A	ILE10-LEU28
B	ILE10-LEU28
C	ILE10-LEU28

site_id	SWS_FT_FI3
Number of Residues	1932
Details	TOPO_DOM: Periplasmic => ECO:0000269\|PubMed:15919996

Chain	Residue	Details
A	LYS29-SER336
B	PHE556-ASN871
B	ARG919-ASP924
B	THR993-GLY998
C	LYS29-SER336
C	PHE386-ASN391
C	PHE458-ALA465
C	PHE556-ASN871
C	ARG919-ASP924
C	THR993-GLY998
A	PHE386-ASN391
A	PHE458-ALA465
A	PHE556-ASN871
A	ARG919-ASP924
A	THR993-GLY998
B	LYS29-SER336
B	PHE386-ASN391
B	PHE458-ALA465

site_id	SWS_FT_FI4
Number of Residues	57
Details	TRANSMEM: Helical; Name=2

Chain	Residue	Details
A	ILE337-TYR356
B	ILE337-TYR356
C	ILE337-TYR356

site_id	SWS_FT_FI5
Number of Residues	57
Details	TRANSMEM: Helical; Name=3

Chain	Residue	Details
A	LEU366-ALA385
B	LEU366-ALA385
C	LEU366-ALA385

site_id	SWS_FT_FI6
Number of Residues	63
Details	TRANSMEM: Helical; Name=4

Chain	Residue	Details
A	THR392-VAL413
B	THR392-VAL413
C	THR392-VAL413

site_id	SWS_FT_FI7
Number of Residues	54
Details	TRANSMEM: Helical; Name=5

Chain	Residue	Details
A	GLN439-ALA457
B	GLN439-ALA457
C	GLN439-ALA457

site_id	SWS_FT_FI8
Number of Residues	72
Details	TRANSMEM: Helical; Name=6

Chain	Residue	Details
A	ILE466-PRO490
B	ILE466-PRO490
C	ILE466-PRO490

site_id	SWS_FT_FI9
Number of Residues	48
Details	TRANSMEM: Helical; Name=7

Chain	Residue	Details
A	GLY539-LEU555
B	GLY539-LEU555
C	GLY539-LEU555

site_id	SWS_FT_FI10
Number of Residues	48
Details	TRANSMEM: Helical; Name=8

Chain	Residue	Details
A	GLN872-LEU888
B	GLN872-LEU888
C	GLN872-LEU888

site_id	SWS_FT_FI11
Number of Residues	57
Details	TRANSMEM: Helical; Name=9

Chain	Residue	Details
A	PHE899-PHE918
B	PHE899-PHE918
C	PHE899-PHE918

site_id	SWS_FT_FI12
Number of Residues	54
Details	TRANSMEM: Helical; Name=10

Chain	Residue	Details
A	VAL925-ILE943
B	VAL925-ILE943
C	VAL925-ILE943

site_id	SWS_FT_FI13
Number of Residues	57
Details	TRANSMEM: Helical; Name=11

Chain	Residue	Details
A	ARG973-SER992
B	ARG973-SER992
C	ARG973-SER992

site_id	SWS_FT_FI14
Number of Residues	57
Details	TRANSMEM: Helical; Name=12

Chain	Residue	Details
A	ALA999-ALA1018
B	ALA999-ALA1018
C	ALA999-ALA1018

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)