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6ZNN

The pointed end complex of dynactin bound to Hook3

Functional Information from GO Data
ChainGOidnamespacecontents
H0000166molecular_functionnucleotide binding
H0000786cellular_componentnucleosome
H0001738biological_processmorphogenesis of a polarized epithelium
H0005515molecular_functionprotein binding
H0005524molecular_functionATP binding
H0005634cellular_componentnucleus
H0005737cellular_componentcytoplasm
H0005829cellular_componentcytosol
H0005856cellular_componentcytoskeleton
H0005884cellular_componentactin filament
H0005886cellular_componentplasma membrane
H0005903cellular_componentbrush border
H0005911cellular_componentcell-cell junction
H0005912cellular_componentadherens junction
H0005925cellular_componentfocal adhesion
H0007163biological_processestablishment or maintenance of cell polarity
H0007409biological_processaxonogenesis
H0015629cellular_componentactin cytoskeleton
H0016020cellular_componentmembrane
H0016787molecular_functionhydrolase activity
H0016887molecular_functionATP hydrolysis activity
H0019894molecular_functionkinesin binding
H0019901molecular_functionprotein kinase binding
H0030027cellular_componentlamellipodium
H0030235molecular_functionnitric-oxide synthase regulator activity
H0030424cellular_componentaxon
H0030863cellular_componentcortical cytoskeleton
H0030957molecular_functionTat protein binding
H0032991cellular_componentprotein-containing complex
H0034333biological_processadherens junction assembly
H0035267cellular_componentNuA4 histone acetyltransferase complex
H0036464cellular_componentcytoplasmic ribonucleoprotein granule
H0042802molecular_functionidentical protein binding
H0043296cellular_componentapical junction complex
H0044305cellular_componentcalyx of Held
H0045176biological_processapical protein localization
H0045202cellular_componentsynapse
H0048870biological_processcell motility
H0050998molecular_functionnitric-oxide synthase binding
H0051621biological_processregulation of norepinephrine uptake
H0051726biological_processregulation of cell cycle
H0070160cellular_componenttight junction
H0071896biological_processprotein localization to adherens junction
H0072749biological_processcellular response to cytochalasin B
H0097433cellular_componentdense body
H0098685cellular_componentSchaffer collateral - CA1 synapse
H0098871cellular_componentpostsynaptic actin cytoskeleton
H0098973molecular_functionstructural constituent of postsynaptic actin cytoskeleton
H0098974biological_processpostsynaptic actin cytoskeleton organization
H0098978cellular_componentglutamatergic synapse
H0141108molecular_functiontransporter regulator activity
H0150111biological_processregulation of transepithelial transport
H1900242biological_processregulation of synaptic vesicle endocytosis
H1903076biological_processregulation of protein localization to plasma membrane
H1905168biological_processpositive regulation of double-strand break repair via homologous recombination
H1990904cellular_componentribonucleoprotein complex
J0005737cellular_componentcytoplasm
J0005856cellular_componentcytoskeleton
J0005869cellular_componentdynactin complex
J0098958biological_processretrograde axonal transport of mitochondrion
J1904115cellular_componentaxon cytoplasm
M0005737cellular_componentcytoplasm
M0005813cellular_componentcentrosome
M0005856cellular_componentcytoskeleton
M0005869cellular_componentdynactin complex
M0005874cellular_componentmicrotubule
M0007017biological_processmicrotubule-based process
M0007052biological_processmitotic spindle organization
M0016020cellular_componentmembrane
M0030286cellular_componentdynein complex
U0000775cellular_componentchromosome, centromeric region
U0000776cellular_componentkinetochore
U0005694cellular_componentchromosome
U0005737cellular_componentcytoplasm
U0005813cellular_componentcentrosome
U0005856cellular_componentcytoskeleton
U0005869cellular_componentdynactin complex
U0007052biological_processmitotic spindle organization
U0015630cellular_componentmicrotubule cytoskeleton
U0070840molecular_functiondynein complex binding
V0000775cellular_componentchromosome, centromeric region
V0000776cellular_componentkinetochore
V0003281biological_processventricular septum development
V0005654cellular_componentnucleoplasm
V0005694cellular_componentchromosome
V0005737cellular_componentcytoplasm
V0005813cellular_componentcentrosome
V0005856cellular_componentcytoskeleton
V0005869cellular_componentdynactin complex
V0031965cellular_componentnuclear membrane
V0035904biological_processaorta development
V0060976biological_processcoronary vasculature development
Y0001725cellular_componentstress fiber
Y0005737cellular_componentcytoplasm
Y0005813cellular_componentcentrosome
Y0005856cellular_componentcytoskeleton
Y0005869cellular_componentdynactin complex
Y0005938cellular_componentcell cortex
Y0030017cellular_componentsarcomere
Functional Information from PDB Data
site_idAC1
Number of Residues11
Detailsbinding site for residue ADP G 800
ChainResidue
GGLY17
GSER304
GLEU337
GLYS22
GASP159
GASP162
GLYS215
GLYS218
GGLU219
GGLY302
GGLY303

site_idAC2
Number of Residues18
Detailsbinding site for residue ATP H 401
ChainResidue
HASP11
HGLY13
HSER14
HGLY15
HMET16
HLYS18
HGLN137
HGLY156
HASP157
HARG210
HLYS213
HGLU214
HGLY302
HTHR303
HMET305
HTYR306
HLYS336
HVAL339

site_idAC3
Number of Residues13
Detailsbinding site for residue ADP I 800
ChainResidue
IGLY17
IVAL20
ILYS22
IGLN142
IGLY161
IASP162
ILYS218
IGLU219
IGLY302
IGLY303
ISER304
ILEU306
ILEU337

site_idAC4
Number of Residues16
Detailsbinding site for residue ADP J 800
ChainResidue
JGLY21
JGLU22
JALA23
JPHE24
JLYS26
JGLY142
JTYR143
JHIS172
JGLU208
JLYS211
JGLY308
JTHR309
JMET311
JASN351
YARG255
YGLN262

site_idAC5
Number of Residues4
Detailsbinding site for residue ZN Y 501
ChainResidue
YCYS30
YCYS33
YARG37
YCYS287

site_idAC6
Number of Residues4
Detailsbinding site for residue ZN Y 502
ChainResidue
YCYS51
YCYS54
YCYS70
YCYS73

site_idAC7
Number of Residues4
Detailsbinding site for residue ZN Y 503
ChainResidue
YCYS76
YCYS79
YCYS111
YCYS114

Functional Information from PROSITE/UniProt
site_idPS00406
Number of Residues11
DetailsACTINS_1 Actins signature 1. YVGDEAQs.KRG
ChainResidueDetails
HTYR53-GLY63

site_idPS00432
Number of Residues9
DetailsACTINS_2 Actins signature 2. WISKqEYDE
ChainResidueDetails
HTRP356-GLU364
GTRP357-GLU365

site_idPS01132
Number of Residues13
DetailsACTINS_ACT_LIKE Actins and actin-related proteins signature. LLTEApLNPkaNR
ChainResidueDetails
HLEU104-ARG116
GLEU109-ARG121

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues1
DetailsMOD_RES: N-acetylalanine => ECO:0000250|UniProtKB:Q9UJW0
ChainResidueDetails
YALA2
IMET1

site_idSWS_FT_FI2
Number of Residues1
DetailsMOD_RES: Phosphothreonine => ECO:0000250|UniProtKB:Q9QUR2
ChainResidueDetails
YTHR414

site_idSWS_FT_FI3
Number of Residues2
DetailsCROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0000250|UniProtKB:Q9UJW0
ChainResidueDetails
YLYS222
HMET47

site_idSWS_FT_FI4
Number of Residues1
DetailsMOD_RES: Phosphotyrosine => ECO:0000250|UniProtKB:Q99KJ8
ChainResidueDetails
MTYR88

site_idSWS_FT_FI5
Number of Residues1
DetailsMOD_RES: Phosphothreonine => ECO:0000250|UniProtKB:Q13561
ChainResidueDetails
MTHR136

site_idSWS_FT_FI6
Number of Residues1
DetailsMOD_RES: Phosphoserine => ECO:0000250|UniProtKB:Q99KJ8
ChainResidueDetails
MSER324

237423

PDB entries from 2025-06-11

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