6ZNM

The pointed end complex of dynactin bound to BICDR1

Functional Information from GO Data

Chain	GOid	namespace	contents
H	0005515	molecular_function	protein binding
H	0005524	molecular_function	ATP binding
H	0005634	cellular_component	nucleus
H	0005737	cellular_component	cytoplasm
H	0005856	cellular_component	cytoskeleton
H	0005884	cellular_component	actin filament
H	0005886	cellular_component	plasma membrane
H	0005925	cellular_component	focal adhesion
H	0007409	biological_process	axonogenesis
H	0015629	cellular_component	actin cytoskeleton
H	0016020	cellular_component	membrane
H	0016787	molecular_function	hydrolase activity
H	0019901	molecular_function	protein kinase binding
H	0030424	cellular_component	axon
H	0032991	cellular_component	protein-containing complex
H	0035267	cellular_component	NuA4 histone acetyltransferase complex
H	0045202	cellular_component	synapse
H	0048870	biological_process	cell motility
H	0097433	cellular_component	dense body
H	0098973	molecular_function	structural constituent of postsynaptic actin cytoskeleton
H	0098974	biological_process	postsynaptic actin cytoskeleton organization
J	0005737	cellular_component	cytoplasm
J	0005856	cellular_component	cytoskeleton
J	0005869	cellular_component	dynactin complex
J	0098958	biological_process	retrograde axonal transport of mitochondrion
J	1904115	cellular_component	axon cytoplasm
M	0005737	cellular_component	cytoplasm
M	0005813	cellular_component	centrosome
M	0005856	cellular_component	cytoskeleton
M	0005869	cellular_component	dynactin complex
M	0005874	cellular_component	microtubule
M	0007017	biological_process	microtubule-based process
M	0016020	cellular_component	membrane
M	0030286	cellular_component	dynein complex
U	0000775	cellular_component	chromosome, centromeric region
U	0000776	cellular_component	kinetochore
U	0005694	cellular_component	chromosome
U	0005737	cellular_component	cytoplasm
U	0005856	cellular_component	cytoskeleton
U	0005869	cellular_component	dynactin complex
U	0007052	biological_process	mitotic spindle organization
U	0070840	molecular_function	dynein complex binding
V	0000775	cellular_component	chromosome, centromeric region
V	0000776	cellular_component	kinetochore
V	0005694	cellular_component	chromosome
V	0005737	cellular_component	cytoplasm
V	0005856	cellular_component	cytoskeleton
V	0005869	cellular_component	dynactin complex
Y	0001725	cellular_component	stress fiber
Y	0005737	cellular_component	cytoplasm
Y	0005813	cellular_component	centrosome
Y	0005856	cellular_component	cytoskeleton
Y	0005869	cellular_component	dynactin complex
Y	0005938	cellular_component	cell cortex
Y	0030017	cellular_component	sarcomere

Functional Information from PDB Data

site_id	AC1
Number of Residues	11
Details	binding site for residue ADP G 800

Chain	Residue
G	GLY17
G	SER304
G	LEU337
G	LYS22
G	ASP159
G	ASP162
G	LYS215
G	LYS218
G	GLU219
G	GLY302
G	GLY303

---

site_id	AC2
Number of Residues	18
Details	binding site for residue ATP H 401

Chain	Residue
H	ASP11
H	GLY13
H	SER14
H	GLY15
H	MET16
H	LYS18
H	GLN137
H	GLY156
H	ASP157
H	ARG210
H	LYS213
H	GLU214
H	GLY302
H	THR303
H	MET305
H	TYR306
H	LYS336
H	VAL339

---

site_id	AC3
Number of Residues	13
Details	binding site for residue ADP I 800

Chain	Residue
I	GLY17
I	VAL20
I	LYS22
I	GLN142
I	GLY161
I	ASP162
I	LYS218
I	GLU219
I	GLY302
I	GLY303
I	SER304
I	LEU306
I	LEU337

---

site_id	AC4
Number of Residues	16
Details	binding site for residue ADP J 800

Chain	Residue
J	GLY21
J	GLU22
J	ALA23
J	PHE24
J	LYS26
J	GLY142
J	TYR143
J	HIS172
J	GLU208
J	LYS211
J	GLY308
J	THR309
J	MET311
J	ASN351
Y	ARG255
Y	GLN262

---

site_id	AC5
Number of Residues	4
Details	binding site for residue ZN Y 501

Chain	Residue
Y	CYS30
Y	CYS33
Y	ARG37
Y	CYS287

---

site_id	AC6
Number of Residues	4
Details	binding site for residue ZN Y 502

Chain	Residue
Y	CYS51
Y	CYS54
Y	CYS70
Y	CYS73

---

site_id	AC7
Number of Residues	4
Details	binding site for residue ZN Y 503

Chain	Residue
Y	CYS76
Y	CYS79
Y	CYS111
Y	CYS114

---

Functional Information from PROSITE/UniProt

site_id	PS00406
Number of Residues	11
Details	ACTINS_1 Actins signature 1. YVGDEAQs.KRG

Chain	Residue	Details
H	TYR53-GLY63

---

site_id	PS00432
Number of Residues	9
Details	ACTINS_2 Actins signature 2. WVSKkEYEE

Chain	Residue	Details
G	TRP357-GLU365
H	TRP356-GLU364

---

site_id	PS01132
Number of Residues	13
Details	ACTINS_ACT_LIKE Actins and actin-related proteins signature. LLTEApLNPrkNR

Chain	Residue	Details
G	LEU109-ARG121
H	LEU104-ARG116

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	MOD_RES: N-acetylalanine => ECO:0000250|UniProtKB:Q9UJW0

Chain	Residue	Details
Y	ALA2
I	MET1

---

site_id	SWS_FT_FI2
Number of Residues	1
Details	MOD_RES: Phosphothreonine => ECO:0000250|UniProtKB:Q9QUR2

Chain	Residue	Details
Y	THR414

---

site_id	SWS_FT_FI3
Number of Residues	2
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0000250|UniProtKB:Q9UJW0

Chain	Residue	Details
Y	LYS222
H	MET47

---

site_id	SWS_FT_FI4
Number of Residues	1
Details	MOD_RES: Phosphotyrosine => ECO:0000250|UniProtKB:Q99KJ8

Chain	Residue	Details
M	TYR88

---

site_id	SWS_FT_FI5
Number of Residues	1
Details	MOD_RES: Phosphothreonine => ECO:0000250|UniProtKB:Q13561

Chain	Residue	Details
M	THR136

---

site_id	SWS_FT_FI6
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:Q99KJ8

Chain	Residue	Details
M	SER324

---