6ZLQ

Folding of an iron binding peptide in response to sedimentation is resolved using ferritin as a nano-reactor

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005506	molecular_function	iron ion binding
A	0005515	molecular_function	protein binding
A	0005576	cellular_component	extracellular region
A	0005737	cellular_component	cytoplasm
A	0006826	biological_process	iron ion transport
A	0006879	biological_process	intracellular iron ion homeostasis
A	0006880	biological_process	intracellular sequestering of iron ion
A	0008043	cellular_component	intracellular ferritin complex
A	0008198	molecular_function	ferrous iron binding
A	0008199	molecular_function	ferric iron binding
A	0044754	cellular_component	autolysosome
A	0046872	molecular_function	metal ion binding
A	0071682	cellular_component	endocytic vesicle lumen
B	0005506	molecular_function	iron ion binding
B	0005515	molecular_function	protein binding
B	0005576	cellular_component	extracellular region
B	0005737	cellular_component	cytoplasm
B	0006826	biological_process	iron ion transport
B	0006879	biological_process	intracellular iron ion homeostasis
B	0006880	biological_process	intracellular sequestering of iron ion
B	0008043	cellular_component	intracellular ferritin complex
B	0008198	molecular_function	ferrous iron binding
B	0008199	molecular_function	ferric iron binding
B	0044754	cellular_component	autolysosome
B	0046872	molecular_function	metal ion binding
B	0071682	cellular_component	endocytic vesicle lumen
C	0005506	molecular_function	iron ion binding
C	0005515	molecular_function	protein binding
C	0005576	cellular_component	extracellular region
C	0005737	cellular_component	cytoplasm
C	0006826	biological_process	iron ion transport
C	0006879	biological_process	intracellular iron ion homeostasis
C	0006880	biological_process	intracellular sequestering of iron ion
C	0008043	cellular_component	intracellular ferritin complex
C	0008198	molecular_function	ferrous iron binding
C	0008199	molecular_function	ferric iron binding
C	0044754	cellular_component	autolysosome
C	0046872	molecular_function	metal ion binding
C	0071682	cellular_component	endocytic vesicle lumen
D	0005506	molecular_function	iron ion binding
D	0005515	molecular_function	protein binding
D	0005576	cellular_component	extracellular region
D	0005737	cellular_component	cytoplasm
D	0006826	biological_process	iron ion transport
D	0006879	biological_process	intracellular iron ion homeostasis
D	0006880	biological_process	intracellular sequestering of iron ion
D	0008043	cellular_component	intracellular ferritin complex
D	0008198	molecular_function	ferrous iron binding
D	0008199	molecular_function	ferric iron binding
D	0044754	cellular_component	autolysosome
D	0046872	molecular_function	metal ion binding
D	0071682	cellular_component	endocytic vesicle lumen
E	0005506	molecular_function	iron ion binding
E	0005515	molecular_function	protein binding
E	0005576	cellular_component	extracellular region
E	0005737	cellular_component	cytoplasm
E	0006826	biological_process	iron ion transport
E	0006879	biological_process	intracellular iron ion homeostasis
E	0006880	biological_process	intracellular sequestering of iron ion
E	0008043	cellular_component	intracellular ferritin complex
E	0008198	molecular_function	ferrous iron binding
E	0008199	molecular_function	ferric iron binding
E	0044754	cellular_component	autolysosome
E	0046872	molecular_function	metal ion binding
E	0071682	cellular_component	endocytic vesicle lumen
F	0005506	molecular_function	iron ion binding
F	0005515	molecular_function	protein binding
F	0005576	cellular_component	extracellular region
F	0005737	cellular_component	cytoplasm
F	0006826	biological_process	iron ion transport
F	0006879	biological_process	intracellular iron ion homeostasis
F	0006880	biological_process	intracellular sequestering of iron ion
F	0008043	cellular_component	intracellular ferritin complex
F	0008198	molecular_function	ferrous iron binding
F	0008199	molecular_function	ferric iron binding
F	0044754	cellular_component	autolysosome
F	0046872	molecular_function	metal ion binding
F	0071682	cellular_component	endocytic vesicle lumen
G	0005506	molecular_function	iron ion binding
G	0005515	molecular_function	protein binding
G	0005576	cellular_component	extracellular region
G	0005737	cellular_component	cytoplasm
G	0006826	biological_process	iron ion transport
G	0006879	biological_process	intracellular iron ion homeostasis
G	0006880	biological_process	intracellular sequestering of iron ion
G	0008043	cellular_component	intracellular ferritin complex
G	0008198	molecular_function	ferrous iron binding
G	0008199	molecular_function	ferric iron binding
G	0044754	cellular_component	autolysosome
G	0046872	molecular_function	metal ion binding
G	0071682	cellular_component	endocytic vesicle lumen
H	0005506	molecular_function	iron ion binding
H	0005515	molecular_function	protein binding
H	0005576	cellular_component	extracellular region
H	0005737	cellular_component	cytoplasm
H	0006826	biological_process	iron ion transport
H	0006879	biological_process	intracellular iron ion homeostasis
H	0006880	biological_process	intracellular sequestering of iron ion
H	0008043	cellular_component	intracellular ferritin complex
H	0008198	molecular_function	ferrous iron binding
H	0008199	molecular_function	ferric iron binding
H	0044754	cellular_component	autolysosome
H	0046872	molecular_function	metal ion binding
H	0071682	cellular_component	endocytic vesicle lumen
I	0005506	molecular_function	iron ion binding
I	0005515	molecular_function	protein binding
I	0005576	cellular_component	extracellular region
I	0005737	cellular_component	cytoplasm
I	0006826	biological_process	iron ion transport
I	0006879	biological_process	intracellular iron ion homeostasis
I	0006880	biological_process	intracellular sequestering of iron ion
I	0008043	cellular_component	intracellular ferritin complex
I	0008198	molecular_function	ferrous iron binding
I	0008199	molecular_function	ferric iron binding
I	0044754	cellular_component	autolysosome
I	0046872	molecular_function	metal ion binding
I	0071682	cellular_component	endocytic vesicle lumen
J	0005506	molecular_function	iron ion binding
J	0005515	molecular_function	protein binding
J	0005576	cellular_component	extracellular region
J	0005737	cellular_component	cytoplasm
J	0006826	biological_process	iron ion transport
J	0006879	biological_process	intracellular iron ion homeostasis
J	0006880	biological_process	intracellular sequestering of iron ion
J	0008043	cellular_component	intracellular ferritin complex
J	0008198	molecular_function	ferrous iron binding
J	0008199	molecular_function	ferric iron binding
J	0044754	cellular_component	autolysosome
J	0046872	molecular_function	metal ion binding
J	0071682	cellular_component	endocytic vesicle lumen
K	0005506	molecular_function	iron ion binding
K	0005515	molecular_function	protein binding
K	0005576	cellular_component	extracellular region
K	0005737	cellular_component	cytoplasm
K	0006826	biological_process	iron ion transport
K	0006879	biological_process	intracellular iron ion homeostasis
K	0006880	biological_process	intracellular sequestering of iron ion
K	0008043	cellular_component	intracellular ferritin complex
K	0008198	molecular_function	ferrous iron binding
K	0008199	molecular_function	ferric iron binding
K	0044754	cellular_component	autolysosome
K	0046872	molecular_function	metal ion binding
K	0071682	cellular_component	endocytic vesicle lumen
L	0005506	molecular_function	iron ion binding
L	0005515	molecular_function	protein binding
L	0005576	cellular_component	extracellular region
L	0005737	cellular_component	cytoplasm
L	0006826	biological_process	iron ion transport
L	0006879	biological_process	intracellular iron ion homeostasis
L	0006880	biological_process	intracellular sequestering of iron ion
L	0008043	cellular_component	intracellular ferritin complex
L	0008198	molecular_function	ferrous iron binding
L	0008199	molecular_function	ferric iron binding
L	0044754	cellular_component	autolysosome
L	0046872	molecular_function	metal ion binding
L	0071682	cellular_component	endocytic vesicle lumen
M	0005506	molecular_function	iron ion binding
M	0005515	molecular_function	protein binding
M	0005576	cellular_component	extracellular region
M	0005737	cellular_component	cytoplasm
M	0006826	biological_process	iron ion transport
M	0006879	biological_process	intracellular iron ion homeostasis
M	0006880	biological_process	intracellular sequestering of iron ion
M	0008043	cellular_component	intracellular ferritin complex
M	0008198	molecular_function	ferrous iron binding
M	0008199	molecular_function	ferric iron binding
M	0044754	cellular_component	autolysosome
M	0046872	molecular_function	metal ion binding
M	0071682	cellular_component	endocytic vesicle lumen
N	0005506	molecular_function	iron ion binding
N	0005515	molecular_function	protein binding
N	0005576	cellular_component	extracellular region
N	0005737	cellular_component	cytoplasm
N	0006826	biological_process	iron ion transport
N	0006879	biological_process	intracellular iron ion homeostasis
N	0006880	biological_process	intracellular sequestering of iron ion
N	0008043	cellular_component	intracellular ferritin complex
N	0008198	molecular_function	ferrous iron binding
N	0008199	molecular_function	ferric iron binding
N	0044754	cellular_component	autolysosome
N	0046872	molecular_function	metal ion binding
N	0071682	cellular_component	endocytic vesicle lumen
O	0005506	molecular_function	iron ion binding
O	0005515	molecular_function	protein binding
O	0005576	cellular_component	extracellular region
O	0005737	cellular_component	cytoplasm
O	0006826	biological_process	iron ion transport
O	0006879	biological_process	intracellular iron ion homeostasis
O	0006880	biological_process	intracellular sequestering of iron ion
O	0008043	cellular_component	intracellular ferritin complex
O	0008198	molecular_function	ferrous iron binding
O	0008199	molecular_function	ferric iron binding
O	0044754	cellular_component	autolysosome
O	0046872	molecular_function	metal ion binding
O	0071682	cellular_component	endocytic vesicle lumen
P	0005506	molecular_function	iron ion binding
P	0005515	molecular_function	protein binding
P	0005576	cellular_component	extracellular region
P	0005737	cellular_component	cytoplasm
P	0006826	biological_process	iron ion transport
P	0006879	biological_process	intracellular iron ion homeostasis
P	0006880	biological_process	intracellular sequestering of iron ion
P	0008043	cellular_component	intracellular ferritin complex
P	0008198	molecular_function	ferrous iron binding
P	0008199	molecular_function	ferric iron binding
P	0044754	cellular_component	autolysosome
P	0046872	molecular_function	metal ion binding
P	0071682	cellular_component	endocytic vesicle lumen
Q	0005506	molecular_function	iron ion binding
Q	0005515	molecular_function	protein binding
Q	0005576	cellular_component	extracellular region
Q	0005737	cellular_component	cytoplasm
Q	0006826	biological_process	iron ion transport
Q	0006879	biological_process	intracellular iron ion homeostasis
Q	0006880	biological_process	intracellular sequestering of iron ion
Q	0008043	cellular_component	intracellular ferritin complex
Q	0008198	molecular_function	ferrous iron binding
Q	0008199	molecular_function	ferric iron binding
Q	0044754	cellular_component	autolysosome
Q	0046872	molecular_function	metal ion binding
Q	0071682	cellular_component	endocytic vesicle lumen
R	0005506	molecular_function	iron ion binding
R	0005515	molecular_function	protein binding
R	0005576	cellular_component	extracellular region
R	0005737	cellular_component	cytoplasm
R	0006826	biological_process	iron ion transport
R	0006879	biological_process	intracellular iron ion homeostasis
R	0006880	biological_process	intracellular sequestering of iron ion
R	0008043	cellular_component	intracellular ferritin complex
R	0008198	molecular_function	ferrous iron binding
R	0008199	molecular_function	ferric iron binding
R	0044754	cellular_component	autolysosome
R	0046872	molecular_function	metal ion binding
R	0071682	cellular_component	endocytic vesicle lumen
S	0005506	molecular_function	iron ion binding
S	0005515	molecular_function	protein binding
S	0005576	cellular_component	extracellular region
S	0005737	cellular_component	cytoplasm
S	0006826	biological_process	iron ion transport
S	0006879	biological_process	intracellular iron ion homeostasis
S	0006880	biological_process	intracellular sequestering of iron ion
S	0008043	cellular_component	intracellular ferritin complex
S	0008198	molecular_function	ferrous iron binding
S	0008199	molecular_function	ferric iron binding
S	0044754	cellular_component	autolysosome
S	0046872	molecular_function	metal ion binding
S	0071682	cellular_component	endocytic vesicle lumen
T	0005506	molecular_function	iron ion binding
T	0005515	molecular_function	protein binding
T	0005576	cellular_component	extracellular region
T	0005737	cellular_component	cytoplasm
T	0006826	biological_process	iron ion transport
T	0006879	biological_process	intracellular iron ion homeostasis
T	0006880	biological_process	intracellular sequestering of iron ion
T	0008043	cellular_component	intracellular ferritin complex
T	0008198	molecular_function	ferrous iron binding
T	0008199	molecular_function	ferric iron binding
T	0044754	cellular_component	autolysosome
T	0046872	molecular_function	metal ion binding
T	0071682	cellular_component	endocytic vesicle lumen
U	0005506	molecular_function	iron ion binding
U	0005515	molecular_function	protein binding
U	0005576	cellular_component	extracellular region
U	0005737	cellular_component	cytoplasm
U	0006826	biological_process	iron ion transport
U	0006879	biological_process	intracellular iron ion homeostasis
U	0006880	biological_process	intracellular sequestering of iron ion
U	0008043	cellular_component	intracellular ferritin complex
U	0008198	molecular_function	ferrous iron binding
U	0008199	molecular_function	ferric iron binding
U	0044754	cellular_component	autolysosome
U	0046872	molecular_function	metal ion binding
U	0071682	cellular_component	endocytic vesicle lumen
V	0005506	molecular_function	iron ion binding
V	0005515	molecular_function	protein binding
V	0005576	cellular_component	extracellular region
V	0005737	cellular_component	cytoplasm
V	0006826	biological_process	iron ion transport
V	0006879	biological_process	intracellular iron ion homeostasis
V	0006880	biological_process	intracellular sequestering of iron ion
V	0008043	cellular_component	intracellular ferritin complex
V	0008198	molecular_function	ferrous iron binding
V	0008199	molecular_function	ferric iron binding
V	0044754	cellular_component	autolysosome
V	0046872	molecular_function	metal ion binding
V	0071682	cellular_component	endocytic vesicle lumen
W	0005506	molecular_function	iron ion binding
W	0005515	molecular_function	protein binding
W	0005576	cellular_component	extracellular region
W	0005737	cellular_component	cytoplasm
W	0006826	biological_process	iron ion transport
W	0006879	biological_process	intracellular iron ion homeostasis
W	0006880	biological_process	intracellular sequestering of iron ion
W	0008043	cellular_component	intracellular ferritin complex
W	0008198	molecular_function	ferrous iron binding
W	0008199	molecular_function	ferric iron binding
W	0044754	cellular_component	autolysosome
W	0046872	molecular_function	metal ion binding
W	0071682	cellular_component	endocytic vesicle lumen
Z	0005506	molecular_function	iron ion binding
Z	0005515	molecular_function	protein binding
Z	0005576	cellular_component	extracellular region
Z	0005737	cellular_component	cytoplasm
Z	0006826	biological_process	iron ion transport
Z	0006879	biological_process	intracellular iron ion homeostasis
Z	0006880	biological_process	intracellular sequestering of iron ion
Z	0008043	cellular_component	intracellular ferritin complex
Z	0008198	molecular_function	ferrous iron binding
Z	0008199	molecular_function	ferric iron binding
Z	0044754	cellular_component	autolysosome
Z	0046872	molecular_function	metal ion binding
Z	0071682	cellular_component	endocytic vesicle lumen

Functional Information from PDB Data

site_id	AC1
Number of Residues	6
Details	binding site for residue FE A 201

Chain	Residue
A	CYS127
A	GLU131
G	CYS127
G	GLU131
V	GLU131
V	FE201

---

site_id	AC2
Number of Residues	7
Details	binding site for residue FE C 201

Chain	Residue
F	GLU131
F	FE201
N	CYS127
N	GLU131
C	CYS127
C	GLU131
F	CYS127

---

site_id	AC3
Number of Residues	6
Details	binding site for residue FE H 201

Chain	Residue
H	CYS127
H	GLU131
R	CYS127
R	GLU131
W	CYS127
W	GLU131

---

site_id	AC4
Number of Residues	6
Details	binding site for residue FE I 201

Chain	Residue
I	CYS127
I	GLU131
I	FE202
M	CYS127
T	CYS127
T	GLU131

---

site_id	AC5
Number of Residues	7
Details	binding site for residue FE I 202

Chain	Residue
I	CYS127
I	GLU131
I	FE201
M	CYS127
M	GLU131
T	CYS127
T	GLU131

---

site_id	AC6
Number of Residues	7
Details	binding site for residue FE J 201

Chain	Residue
J	CYS127
J	GLU131
P	CYS127
P	GLU131
Q	CYS127
Q	GLU131
Q	FE201

---

site_id	AC7
Number of Residues	7
Details	binding site for residue FE O 201

Chain	Residue
B	CYS127
B	GLU131
B	FE201
E	CYS127
E	GLU131
O	CYS127
O	GLU131

---

site_id	AC8
Number of Residues	6
Details	binding site for residue FE Q 201

Chain	Residue
J	CYS127
J	FE201
P	CYS127
P	GLU131
Q	CYS127
Q	GLU131

---

site_id	AC9
Number of Residues	3
Details	binding site for residue FE R 201

Chain	Residue
R	ASP128
R	GLU131
W	GLU131

---

site_id	AD1
Number of Residues	7
Details	binding site for residue FE S 201

Chain	Residue
K	CYS127
K	GLU131
S	CYS127
S	GLU131
U	CYS127
U	GLU131
U	FE201

---

site_id	AD2
Number of Residues	6
Details	binding site for residue FE U 201

Chain	Residue
K	CYS127
K	GLU131
S	CYS127
S	FE201
U	CYS127
U	GLU131

---

site_id	AD3
Number of Residues	7
Details	binding site for residue FE V 201

Chain	Residue
A	CYS127
A	GLU131
A	FE201
G	CYS127
G	GLU131
V	CYS127
V	GLU131

---

site_id	AD4
Number of Residues	6
Details	binding site for residue FE B 201

Chain	Residue
B	CYS127
B	GLU131
E	CYS127
E	GLU131
O	GLU131
O	FE201

---

site_id	AD5
Number of Residues	2
Details	binding site for residue FE D 201

Chain	Residue
D	ASP128
D	GLU131

---

site_id	AD6
Number of Residues	6
Details	binding site for residue FE D 202

Chain	Residue
D	CYS127
D	ASP128
D	GLU131
L	CYS127
Z	CYS127
Z	GLU131

---

site_id	AD7
Number of Residues	6
Details	binding site for residue FE F 201

Chain	Residue
C	CYS127
C	FE201
F	CYS127
F	GLU131
N	CYS127
N	GLU131

---

Functional Information from PROSITE/UniProt

site_id	PS00204
Number of Residues	21
Details	FERRITIN_2 Ferritin iron-binding regions signature 2. DphLCDFLEshYLdkevklIK

Chain	Residue	Details
Z	ASP123-LYS143

---

site_id	PS00540
Number of Residues	19
Details	FERRITIN_1 Ferritin iron-binding regions signature 1. EkREgaERLLefQNdRgGR

Chain	Residue	Details
Z	GLU58-ARG76

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	120
Details	BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00085

Chain	Residue	Details
Z	GLU54
A	GLU64
V	GLU64
W	GLU54
W	GLU57
W	GLU58
W	GLU61
W	GLU64
B	GLU54
B	GLU57
B	GLU58
B	GLU61
C	GLU54
B	GLU64
D	GLU54
D	GLU57
D	GLU58
D	GLU61
D	GLU64
F	GLU54
F	GLU57
F	GLU58
F	GLU61
C	GLU57
F	GLU64
C	GLU58
C	GLU61
C	GLU64
E	GLU54
E	GLU57
E	GLU58
E	GLU61
Z	GLU57
E	GLU64
G	GLU54
G	GLU57
G	GLU58
G	GLU61
G	GLU64
H	GLU54
H	GLU57
H	GLU58
H	GLU61
Z	GLU58
H	GLU64
I	GLU54
I	GLU57
I	GLU58
I	GLU61
I	GLU64
J	GLU54
J	GLU57
J	GLU58
J	GLU61
Z	GLU61
J	GLU64
K	GLU54
K	GLU57
K	GLU58
K	GLU61
K	GLU64
L	GLU54
L	GLU57
L	GLU58
L	GLU61
Z	GLU64
L	GLU64
M	GLU54
M	GLU57
M	GLU58
M	GLU61
M	GLU64
N	GLU54
N	GLU57
N	GLU58
N	GLU61
A	GLU54
N	GLU64
O	GLU54
O	GLU57
O	GLU58
O	GLU61
O	GLU64
P	GLU54
P	GLU57
P	GLU58
P	GLU61
A	GLU57
P	GLU64
Q	GLU54
Q	GLU57
Q	GLU58
Q	GLU61
Q	GLU64
R	GLU54
R	GLU57
R	GLU58
R	GLU61
A	GLU58
R	GLU64
S	GLU54
S	GLU57
S	GLU58
S	GLU61
S	GLU64
T	GLU54
T	GLU57
T	GLU58
T	GLU61
A	GLU61
T	GLU64
U	GLU54
U	GLU57
U	GLU58
U	GLU61
U	GLU64
V	GLU54
V	GLU57
V	GLU58
V	GLU61

---