Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

6ZL1

Crystal structure of human serum albumin in complex with the MCL-1 neutralizing Alphabody CMPX-383B

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005615	cellular_component	extracellular space
B	0005615	cellular_component	extracellular space

Functional Information from PROSITE/UniProt

site_id	PS00212
Number of Residues	25
Details	ALBUMIN_1 Albumin domain signature. YkaafteCCqaAdkaaCLlpkldeL

Chain	Residue	Details
A	TYR185-LEU209
A	TYR377-PHE401
A	PHE575-LEU599

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	BINDING: BINDING => ECO:0000250\|UniProtKB:P02770

Chain	Residue	Details
A	HIS27
B	HIS27

site_id	SWS_FT_FI2
Number of Residues	12
Details	BINDING: BINDING => ECO:0000250\|UniProtKB:P02769

Chain	Residue	Details
A	GLU30
B	GLU276
B	ASP279
B	ASP283
A	ASP37
A	GLU268
A	GLU276
A	ASP279
A	ASP283
B	GLU30
B	ASP37
B	GLU268

site_id	SWS_FT_FI3
Number of Residues	6
Details	BINDING: BINDING => ECO:0000269\|PubMed:28567254, ECO:0007744\|PDB:5IJF

Chain	Residue	Details
A	HIS91
A	HIS271
A	ASP273
B	HIS91
B	HIS271
B	ASP273

site_id	SWS_FT_FI4
Number of Residues	2
Details	BINDING: BINDING => ECO:0000269\|PubMed:656055

Chain	Residue	Details
A	LYS264
B	LYS264

site_id	SWS_FT_FI5
Number of Residues	74
Details	SITE: Not glycated => ECO:0000269\|PubMed:15047055

Chain	Residue	Details
A	LYS28
A	LYS198
A	LYS205
A	LYS214
A	LYS219
A	LYS229
A	LYS236
A	LYS264
A	LYS286
A	LYS298
A	LYS310
A	LYS44
A	LYS383
A	LYS396
A	LYS413
A	LYS426
A	LYS438
A	LYS456
A	LYS460
A	LYS490
A	LYS499
A	LYS524
A	LYS65
A	LYS543
A	LYS548
A	LYS562
A	LYS565
A	LYS581
A	LYS584
A	LYS588
A	LYS598
B	LYS28
B	LYS44
A	LYS88
B	LYS65
B	LYS88
B	LYS97
B	LYS117
B	LYS130
B	LYS160
B	LYS183
B	LYS198
B	LYS205
B	LYS214
A	LYS97
B	LYS219
B	LYS229
B	LYS236
B	LYS264
B	LYS286
B	LYS298
B	LYS310
B	LYS383
B	LYS396
B	LYS413
A	LYS117
B	LYS426
B	LYS438
B	LYS456
B	LYS460
B	LYS490
B	LYS499
B	LYS524
B	LYS543
B	LYS548
B	LYS562
A	LYS130
B	LYS565
B	LYS581
B	LYS584
B	LYS588
B	LYS598
A	LYS160
A	LYS183

site_id	SWS_FT_FI6
Number of Residues	2
Details	SITE: Aspirin-acetylated lysine

Chain	Residue	Details
A	LYS223
B	LYS223

site_id	SWS_FT_FI7
Number of Residues	2
Details	MOD_RES: Phosphoserine; by FAM20C => ECO:0000269\|PubMed:26091039

Chain	Residue	Details
A	SER29
B	SER29

site_id	SWS_FT_FI8
Number of Residues	2
Details	MOD_RES: Phosphoserine; by FAM20C => ECO:0000269\|PubMed:26091039, ECO:0007744\|PubMed:18318008, ECO:0007744\|PubMed:24275569

Chain	Residue	Details
A	SER82
B	SER82

site_id	SWS_FT_FI9
Number of Residues	2
Details	MOD_RES: Phosphoserine; by FAM20C => ECO:0000269\|PubMed:26091039, ECO:0007744\|PubMed:24275569

Chain	Residue	Details
A	SER89
B	SER89

site_id	SWS_FT_FI10
Number of Residues	2
Details	MOD_RES: Phosphothreonine; by FAM20C => ECO:0000269\|PubMed:26091039

Chain	Residue	Details
A	THR107
B	THR107

site_id	SWS_FT_FI11
Number of Residues	8
Details	MOD_RES: N6-succinyllysine => ECO:0000250\|UniProtKB:P07724

Chain	Residue	Details
A	LYS229
A	LYS460
A	LYS543
A	LYS588
B	LYS229
B	LYS460
B	LYS543
B	LYS588

site_id	SWS_FT_FI12
Number of Residues	2
Details	MOD_RES: Phosphoserine => ECO:0000250\|UniProtKB:P07724

Chain	Residue	Details
A	SER297
B	SER297

site_id	SWS_FT_FI13
Number of Residues	2
Details	MOD_RES: Phosphoserine => ECO:0007744\|PubMed:19690332

Chain	Residue	Details
A	SER443
B	SER443

site_id	SWS_FT_FI14
Number of Residues	4
Details	MOD_RES: Phosphothreonine => ECO:0007744\|PubMed:19690332

Chain	Residue	Details
A	THR444
A	THR446
B	THR444
B	THR446

site_id	SWS_FT_FI15
Number of Residues	2
Details	MOD_RES: Phosphoserine => ECO:0007744\|PubMed:24275569

Chain	Residue	Details
A	SER513
B	SER513

site_id	SWS_FT_FI16
Number of Residues	2
Details	MOD_RES: N6-methyllysine; alternate => ECO:0007744\|PubMed:24129315

Chain	Residue	Details
A	LYS558
B	LYS558

site_id	SWS_FT_FI17
Number of Residues	8
Details	CARBOHYD: N-linked (Glc) (glycation) lysine => ECO:0000269\|PubMed:3759977

Chain	Residue	Details
A	LYS36
A	LYS305
A	LYS341
A	LYS463
B	LYS36
B	LYS305
B	LYS341
B	LYS463

site_id	SWS_FT_FI18
Number of Residues	26
Details	CARBOHYD: N-linked (Glc) (glycation) lysine; in vitro => ECO:0000269\|PubMed:15047055

Chain	Residue	Details
A	LYS75
A	LYS468
A	LYS560
A	LYS569
A	LYS597
B	LYS75
B	LYS161
B	LYS186
B	LYS249
B	LYS300
B	LYS337
A	LYS161
B	LYS347
B	LYS402
B	LYS437
B	LYS468
B	LYS560
B	LYS569
B	LYS597
A	LYS186
A	LYS249
A	LYS300
A	LYS337
A	LYS347
A	LYS402
A	LYS437

site_id	SWS_FT_FI19
Number of Residues	2
Details	CARBOHYD: N-linked (Glc) (glycation) lysine; in vitro => ECO:0000269\|PubMed:3759977, ECO:0000269\|PubMed:6853480

Chain	Residue	Details
A	LYS223
B	LYS223

site_id	SWS_FT_FI20
Number of Residues	4
Details	CARBOHYD: N-linked (Glc) (glycation) lysine => ECO:0000269\|PubMed:15047055, ECO:0000269\|PubMed:3759977

Chain	Residue	Details
A	LYS257
A	LYS375
B	LYS257
B	LYS375

site_id	SWS_FT_FI21
Number of Residues	2
Details	CARBOHYD: N-linked (GlcNAc...) asparagine; in variant Redhill

Chain	Residue	Details
A	ASN342
B	ASN342

site_id	SWS_FT_FI22
Number of Residues	2
Details	CARBOHYD: N-linked (GlcNAc...) asparagine; in variant Casebrook

Chain	Residue	Details
A	ASP518
B	ASP518

site_id	SWS_FT_FI23
Number of Residues	2
Details	CARBOHYD: N-linked (Glc) (glycation) lysine => ECO:0000269\|PubMed:15047055, ECO:0000269\|PubMed:3759977, ECO:0000269\|PubMed:6706980, ECO:0000269\|PubMed:6853480

Chain	Residue	Details
A	LYS549
B	LYS549

site_id	SWS_FT_FI24
Number of Residues	2
Details	CARBOHYD: N-linked (Glc) (glycation) lysine; alternate => ECO:0000269\|PubMed:3759977

Chain	Residue	Details
A	LYS558
B	LYS558

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)