Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

6ZKB

Membrane domain of closed complex I during turnover

Functional Information from GO Data

Chain	GOid	namespace	contents
4	0016651	molecular_function	oxidoreductase activity, acting on NAD(P)H
4	0048038	molecular_function	quinone binding
4	0051287	molecular_function	NAD binding
A	0005743	cellular_component	mitochondrial inner membrane
A	0006120	biological_process	mitochondrial electron transport, NADH to ubiquinone
A	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
A	0022904	biological_process	respiratory electron transport chain
A	0030964	cellular_component	NADH dehydrogenase complex
A	0045271	cellular_component	respiratory chain complex I
A	1902600	biological_process	proton transmembrane transport
H	0003954	molecular_function	NADH dehydrogenase activity
H	0005743	cellular_component	mitochondrial inner membrane
H	0006120	biological_process	mitochondrial electron transport, NADH to ubiquinone
H	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
H	0009060	biological_process	aerobic respiration
H	0016020	cellular_component	membrane
H	0022904	biological_process	respiratory electron transport chain
H	0031966	cellular_component	mitochondrial membrane
H	0032981	biological_process	mitochondrial respiratory chain complex I assembly
H	0045271	cellular_component	respiratory chain complex I
H	1902600	biological_process	proton transmembrane transport
J	0005739	cellular_component	mitochondrion
J	0005743	cellular_component	mitochondrial inner membrane
J	0006120	biological_process	mitochondrial electron transport, NADH to ubiquinone
J	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
J	0022904	biological_process	respiratory electron transport chain
J	0032981	biological_process	mitochondrial respiratory chain complex I assembly
J	0045271	cellular_component	respiratory chain complex I
J	1902600	biological_process	proton transmembrane transport
k	0006120	biological_process	mitochondrial electron transport, NADH to ubiquinone
K	0005743	cellular_component	mitochondrial inner membrane
K	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
K	0016651	molecular_function	oxidoreductase activity, acting on NAD(P)H
K	0022904	biological_process	respiratory electron transport chain
K	0030964	cellular_component	NADH dehydrogenase complex
K	0042773	biological_process	ATP synthesis coupled electron transport
K	0045271	cellular_component	respiratory chain complex I
K	1902600	biological_process	proton transmembrane transport
L	0003954	molecular_function	NADH dehydrogenase activity
L	0005743	cellular_component	mitochondrial inner membrane
L	0006120	biological_process	mitochondrial electron transport, NADH to ubiquinone
L	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
L	0015990	biological_process	electron transport coupled proton transport
L	0022904	biological_process	respiratory electron transport chain
L	0032981	biological_process	mitochondrial respiratory chain complex I assembly
L	0042773	biological_process	ATP synthesis coupled electron transport
L	0045271	cellular_component	respiratory chain complex I
m	0005743	cellular_component	mitochondrial inner membrane
m	0045271	cellular_component	respiratory chain complex I
M	0003954	molecular_function	NADH dehydrogenase activity
M	0005743	cellular_component	mitochondrial inner membrane
M	0006120	biological_process	mitochondrial electron transport, NADH to ubiquinone
M	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
M	0009060	biological_process	aerobic respiration
M	0015990	biological_process	electron transport coupled proton transport
M	0022904	biological_process	respiratory electron transport chain
M	0032981	biological_process	mitochondrial respiratory chain complex I assembly
M	0042773	biological_process	ATP synthesis coupled electron transport
M	0045271	cellular_component	respiratory chain complex I
M	0048039	molecular_function	ubiquinone binding
n	0005739	cellular_component	mitochondrion
n	0022900	biological_process	electron transport chain
N	0005743	cellular_component	mitochondrial inner membrane
N	0006120	biological_process	mitochondrial electron transport, NADH to ubiquinone
N	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
N	0022904	biological_process	respiratory electron transport chain
N	0032981	biological_process	mitochondrial respiratory chain complex I assembly
N	0045271	cellular_component	respiratory chain complex I
N	1902600	biological_process	proton transmembrane transport
o	0005743	cellular_component	mitochondrial inner membrane
o	0006120	biological_process	mitochondrial electron transport, NADH to ubiquinone
p	0005739	cellular_component	mitochondrion
r	0006120	biological_process	mitochondrial electron transport, NADH to ubiquinone
s	0005739	cellular_component	mitochondrion
t	0006120	biological_process	mitochondrial electron transport, NADH to ubiquinone
u	0005743	cellular_component	mitochondrial inner membrane
u	0045271	cellular_component	respiratory chain complex I
v	0005739	cellular_component	mitochondrion
v	0006120	biological_process	mitochondrial electron transport, NADH to ubiquinone
V	0005743	cellular_component	mitochondrial inner membrane
V	0006120	biological_process	mitochondrial electron transport, NADH to ubiquinone
V	0045271	cellular_component	respiratory chain complex I
x	0005739	cellular_component	mitochondrion
x	0045271	cellular_component	respiratory chain complex I
X	0006633	biological_process	fatty acid biosynthetic process
y	0005739	cellular_component	mitochondrion
Y	0006120	biological_process	mitochondrial electron transport, NADH to ubiquinone

Functional Information from PDB Data

site_id	AC1
Number of Residues	14
Details	binding site for residue 3PE L 1001

Chain	Residue
L	ASP163
L	THR537
L	ASN541
v	ASN87
v	ARG88
v	VAL89
L	THR166
L	GLN170
L	LEU173
L	TYR174
L	GLY228
L	TYR529
L	MET533
L	HIS534

site_id	AC2
Number of Residues	17
Details	binding site for residue PC1 L 1002

Chain	Residue
L	TRP66
L	HIS67
L	TRP68
L	SER77
L	ASN136
L	PHE138
L	ILE142
M	LEU449
W	CDL201
r	ILE80
r	TYR83
r	TYR84
r	HIS88
r	LYS92
w	GLN86
w	GLU87
w	PC1801

site_id	AC3
Number of Residues	22
Details	binding site for residue CDL L 1003

Chain	Residue
L	ASN23
L	PHE24
L	ASN25
L	GLN116
L	LYS119
L	TYR120
L	LEU123
L	THR127
L	MET150
M	LEU354
M	ALA357
M	TRP358
M	LEU360
M	LEU361
M	LEU364
M	LEU369
M	PRO370
M	PRO371
M	SER372
M	LEU445
W	LEU22
W	CDL201

site_id	AC4
Number of Residues	4
Details	binding site for residue 3PE L 1004

Chain	Residue
L	ILE495
L	PHE498
L	ILE499
n	VAL63

site_id	AC5
Number of Residues	5
Details	binding site for residue 3PE M 501

Chain	Residue
M	ASN188
M	TRP190
M	PRO260
M	PHE261
V	LEU87

site_id	AC6
Number of Residues	12
Details	binding site for residue PC1 M 502

Chain	Residue
M	TYR166
M	SER191
M	PHE194
M	MET195
M	LEU197
N	ASP274
N	ILE276
N	ILE277
N	THR280
N	3PE401
V	GLU130
V	TRP132

site_id	AC7
Number of Residues	20
Details	binding site for residue CDL M 503

Chain	Residue
M	LEU2
M	MET9
M	MET10
M	SER53
M	THR55
M	LEU104
M	PHE105
M	PHE117
M	HOH604
N	PRO338
Y	PHE168
Y	TRP169
Y	THR170
Y	MET171
o	PRO29
o	ARG30
o	TYR33
o	PHE36
y	ASN30
y	LYS33

site_id	AC8
Number of Residues	24
Details	binding site for residue CDL M 504

Chain	Residue
M	VAL127
M	ILE131
M	ARG135
M	HOH618
M	HOH621
N	PRO238
N	THR241
N	ILE242
N	ILE246
N	MET335
k	TYR304
o	GLY35
o	PHE36
o	TYR39
o	LEU43
o	ILE44
o	ALA47
o	VAL53
o	LEU54
M	TRP16
M	ALA90
M	ARG91
M	LEU94
M	MET98

site_id	AC9
Number of Residues	17
Details	binding site for residue 3PE N 401

Chain	Residue
4	TRP10
4	GLN13
4	TYR14
4	TYR20
L	PRO563
L	SER567
L	GLN570
L	MET571
M	ASN144
M	LEU147
M	TYR148
M	PHE151
M	TYR152
M	PC1502
N	ILE284
N	TYR291
N	ARG295

site_id	AD1
Number of Residues	7
Details	binding site for residue 3PE N 402

Chain	Residue
N	SER125
N	LEU128
N	ILE129
N	THR132
N	TRP133
N	MET220
N	MET329

site_id	AD2
Number of Residues	13
Details	binding site for residue CDL N 403

Chain	Residue
N	MET323
N	THR324
N	LEU325
o	ASP45
o	ARG60
o	LEU63
o	TYR64
o	SER67
o	PHE68
x	LYS16
x	LEU19
x	THR20
x	THR23

site_id	AD3
Number of Residues	6
Details	binding site for residue 3PE V 201

Chain	Residue
V	LEU5
V	HIS6
V	TRP9
V	LEU123
V	TRP132
V	HOH603

site_id	AD4
Number of Residues	18
Details	binding site for residue CDL V 202

Chain	Residue
L	THR576
L	ILE577
L	SER579
L	GLN580
L	SER598
L	PHE604
N	PHE113
N	LEU157
V	AYA1
V	TYR8
V	ILE27
V	SER31
V	TYR38
V	SER39
V	LYS43
V	TYR58
V	PHE69
V	CDL203

site_id	AD5
Number of Residues	9
Details	binding site for residue CDL V 203

Chain	Residue
L	ILE561
L	THR565
L	LYS572
V	GLY108
V	ILE109
V	ALA112
V	TYR116
V	CDL202
p	PRO81

site_id	AD6
Number of Residues	19
Details	binding site for residue CDL W 201

Chain	Residue
L	LEU12
L	THR16
L	ASN65
L	PC11002
L	CDL1003
W	ILE40
W	THR41
W	ASN44
W	GLU49
W	HIS69
Z	VAL47
Z	ARG48
Z	ILE51
r	TRP79
r	TYR83
r	HIS88
w	THR75
w	TYR79
w	PC1801

site_id	AD7
Number of Residues	9
Details	binding site for residue ZMP X 101

Chain	Residue
X	ASP43
X	SER44
t	HIS11
t	GLN12
t	ARG46
t	PHE47
t	HIS50
t	LYS51
t	ALA66

site_id	AD8
Number of Residues	12
Details	binding site for residue AMP k 501

Chain	Residue
k	ILE31
k	SEP36
k	GLU53
k	LEU79
k	TYR83
k	GLN97
k	LEU100
k	ARG104
k	ARG126
k	ASP131
k	PHE134
k	HOH601

site_id	AD9
Number of Residues	4
Details	binding site for residue 3PE o 501

Chain	Residue
N	TYR143
N	ILE345
o	LEU11
o	ARG78

site_id	AE1
Number of Residues	7
Details	binding site for residue 3PE p 201

Chain	Residue
L	TRP557
V	TYR107
V	GLY108
p	PRO81
p	ASN82
p	SER86
p	GLY89

site_id	AE2
Number of Residues	6
Details	binding site for residue MYR s 201

Chain	Residue
L	LEU413
L	TYR485
L	THR489
s	GLY1
s	ALA2
v	THR124

site_id	AE3
Number of Residues	15
Details	binding site for residue PC1 w 801

Chain	Residue
L	TRP66
L	PC11002
M	PRO64
M	LEU68
M	TRP71
M	LEU446
M	LEU447
M	ASN450
W	CDL201
w	VAL69
w	GLY73
w	SER74
w	VAL77
w	ALA78
w	TYR79

site_id	AE4
Number of Residues	8
Details	binding site for residue 3PE A 201

Chain	Residue
A	PHE96
A	TRP106
H	PRO295
m	PHE7
m	GLU15
m	LEU18
m	PHE22
m	ALA25

site_id	AE5
Number of Residues	12
Details	binding site for residue PC1 H 401

Chain	Residue
H	TRP179
H	PRO180
H	ALA182
H	MET183
H	PHE186
H	ILE187
H	TYR277
H	LEU288
H	ASN292
H	PHE293
H	LEU296
m	GLU15

site_id	AE6
Number of Residues	14
Details	binding site for residue 3PE J 201

Chain	Residue
A	LEU3
A	LEU7
H	ASN99
H	LEU100
H	PHE104
H	MET108
J	GLY38
J	GLY42
J	LEU45
J	SER50
q	PHE139
q	ILE140
q	THR143
z	ALA39

site_id	AE7
Number of Residues	10
Details	binding site for residue 3PE J 202

Chain	Residue
J	SER21
J	LYS23
J	VAL88
J	THR92
J	MET99
K	THR17
K	MET21
K	TYR22
K	ARG23
L	LYS585

Functional Information from PROSITE/UniProt

site_id	PS00012
Number of Residues	16
Details	PHOSPHOPANTETHEINE Phosphopantetheine attachment site. DLGLDSLDQVEIIMAM

Chain	Residue	Details
X	ASP39-MET54

site_id	PS00018
Number of Residues	13
Details	EF_HAND_1 EF-hand calcium-binding domain. DIDAEKLMCpqEI

Chain	Residue	Details
X	ASP64-ILE76

site_id	PS00535
Number of Residues	12
Details	COMPLEX1_49K Respiratory chain NADH dehydrogenase 49 Kd subunit signature. LHRGtEKLiEyK

Chain	Residue	Details
4	LEU77-LYS88

site_id	PS00667
Number of Residues	16
Details	COMPLEX1_ND1_1 Respiratory-chain NADH dehydrogenase subunit 1 signature 1. GLLQpIaDAIKLFiKE

Chain	Residue	Details
H	GLY44-GLU59

site_id	PS00668
Number of Residues	14
Details	COMPLEX1_ND1_2 Respiratory-chain NADH dehydrogenase subunit 1 signature 2. PFDLTEGEseLVs.G

Chain	Residue	Details
H	PRO197-GLY210

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1122
Details	Transmembrane: {"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)