6ZK9
Peripheral domain of open complex I during turnover
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| 1 | 0005739 | cellular_component | mitochondrion |
| 1 | 0005743 | cellular_component | mitochondrial inner membrane |
| 1 | 0005747 | cellular_component | obsolete mitochondrial respiratory chain complex I |
| 1 | 0006120 | biological_process | mitochondrial electron transport, NADH to ubiquinone |
| 1 | 0008137 | molecular_function | NADH dehydrogenase (ubiquinone) activity |
| 1 | 0010181 | molecular_function | FMN binding |
| 1 | 0045271 | cellular_component | respiratory chain complex I |
| 1 | 0046872 | molecular_function | metal ion binding |
| 1 | 0051287 | molecular_function | NAD binding |
| 1 | 0051539 | molecular_function | 4 iron, 4 sulfur cluster binding |
| 1 | 0070469 | cellular_component | respirasome |
| 1 | 1902600 | biological_process | proton transmembrane transport |
| 2 | 0003954 | molecular_function | NADH dehydrogenase activity |
| 2 | 0005747 | cellular_component | obsolete mitochondrial respiratory chain complex I |
| 2 | 0006120 | biological_process | mitochondrial electron transport, NADH to ubiquinone |
| 2 | 0016491 | molecular_function | oxidoreductase activity |
| 2 | 0045271 | cellular_component | respiratory chain complex I |
| 2 | 0046872 | molecular_function | metal ion binding |
| 2 | 0051537 | molecular_function | 2 iron, 2 sulfur cluster binding |
| 3 | 0008137 | molecular_function | NADH dehydrogenase (ubiquinone) activity |
| 3 | 0016020 | cellular_component | membrane |
| 3 | 0016491 | molecular_function | oxidoreductase activity |
| 3 | 0016651 | molecular_function | oxidoreductase activity, acting on NAD(P)H |
| 3 | 0042773 | biological_process | ATP synthesis coupled electron transport |
| 3 | 0051536 | molecular_function | iron-sulfur cluster binding |
| 4 | 0016651 | molecular_function | oxidoreductase activity, acting on NAD(P)H |
| 4 | 0048038 | molecular_function | quinone binding |
| 4 | 0051287 | molecular_function | NAD binding |
| 5 | 0005747 | cellular_component | obsolete mitochondrial respiratory chain complex I |
| 5 | 0008137 | molecular_function | NADH dehydrogenase (ubiquinone) activity |
| 5 | 0016651 | molecular_function | oxidoreductase activity, acting on NAD(P)H |
| 5 | 1902600 | biological_process | proton transmembrane transport |
| 6 | 0008137 | molecular_function | NADH dehydrogenase (ubiquinone) activity |
| 6 | 0048038 | molecular_function | quinone binding |
| 6 | 0051536 | molecular_function | iron-sulfur cluster binding |
| 6 | 0051539 | molecular_function | 4 iron, 4 sulfur cluster binding |
| 9 | 0016020 | cellular_component | membrane |
| 9 | 0016651 | molecular_function | oxidoreductase activity, acting on NAD(P)H |
| 9 | 0051539 | molecular_function | 4 iron, 4 sulfur cluster binding |
| a | 0005739 | cellular_component | mitochondrion |
| a | 0005747 | cellular_component | obsolete mitochondrial respiratory chain complex I |
| b | 0005747 | cellular_component | obsolete mitochondrial respiratory chain complex I |
| b | 0006120 | biological_process | mitochondrial electron transport, NADH to ubiquinone |
| c | 0005739 | cellular_component | mitochondrion |
| c | 0005743 | cellular_component | mitochondrial inner membrane |
| c | 0022900 | biological_process | electron transport chain |
| c | 0070469 | cellular_component | respirasome |
| f | 0022904 | biological_process | respiratory electron transport chain |
| g | 0005739 | cellular_component | mitochondrion |
| g | 0005743 | cellular_component | mitochondrial inner membrane |
| g | 0005747 | cellular_component | obsolete mitochondrial respiratory chain complex I |
| g | 0006979 | biological_process | response to oxidative stress |
| g | 0031966 | cellular_component | mitochondrial membrane |
| g | 0032981 | biological_process | mitochondrial respiratory chain complex I assembly |
| g | 0070469 | cellular_component | respirasome |
| h | 0005743 | cellular_component | mitochondrial inner membrane |
| h | 0016020 | cellular_component | membrane |
| h | 0042773 | biological_process | ATP synthesis coupled electron transport |
| i | 0016020 | cellular_component | membrane |
| i | 0032981 | biological_process | mitochondrial respiratory chain complex I assembly |
| j | 0000035 | molecular_function | acyl binding |
| j | 0000036 | molecular_function | acyl carrier activity |
| j | 0005739 | cellular_component | mitochondrion |
| j | 0005747 | cellular_component | obsolete mitochondrial respiratory chain complex I |
| j | 0006633 | biological_process | fatty acid biosynthetic process |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 12 |
| Details | binding site for residue SF4 1 501 |
| Chain | Residue |
| 1 | ILE185 |
| 1 | ILE404 |
| 1 | CYS405 |
| 1 | LEU407 |
| 1 | PRO203 |
| 1 | SER358 |
| 1 | CYS359 |
| 1 | GLY360 |
| 1 | GLN361 |
| 1 | CYS362 |
| 1 | CYS365 |
| 1 | THR403 |
| site_id | AC2 |
| Number of Residues | 23 |
| Details | binding site for residue FMN 1 502 |
| Chain | Residue |
| 1 | GLY67 |
| 1 | ARG68 |
| 1 | GLY69 |
| 1 | LYS78 |
| 1 | ASN96 |
| 1 | ASP98 |
| 1 | GLU99 |
| 1 | GLY100 |
| 1 | GLY187 |
| 1 | GLU188 |
| 1 | GLU189 |
| 1 | VAL222 |
| 1 | ALA223 |
| 1 | ASN224 |
| 1 | THR227 |
| 1 | LEU407 |
| 1 | NAI503 |
| 1 | HOH607 |
| 1 | HOH622 |
| 1 | HOH636 |
| 1 | HOH652 |
| 1 | HOH663 |
| 1 | HOH682 |
| site_id | AC3 |
| Number of Residues | 20 |
| Details | binding site for residue NAI 1 503 |
| Chain | Residue |
| 1 | GLY69 |
| 1 | GLY70 |
| 1 | ALA71 |
| 1 | PHE73 |
| 1 | LYS78 |
| 1 | PHE81 |
| 1 | GLU99 |
| 1 | GLU101 |
| 1 | TYR184 |
| 1 | GLU189 |
| 1 | PHE209 |
| 1 | SER303 |
| 1 | GLY330 |
| 1 | THR331 |
| 1 | FMN502 |
| 1 | HOH602 |
| 1 | HOH603 |
| 1 | HOH611 |
| 1 | HOH628 |
| 1 | HOH671 |
| site_id | AC4 |
| Number of Residues | 9 |
| Details | binding site for residue FES 2 300 |
| Chain | Residue |
| 2 | CYS103 |
| 2 | THR105 |
| 2 | PRO107 |
| 2 | CYS108 |
| 2 | CYS144 |
| 2 | LEU145 |
| 2 | GLY146 |
| 2 | ALA147 |
| 2 | CYS148 |
| site_id | AC5 |
| Number of Residues | 9 |
| Details | binding site for residue SF4 3 801 |
| Chain | Residue |
| 3 | HIS101 |
| 3 | ASP104 |
| 3 | CYS105 |
| 3 | CYS108 |
| 3 | GLY111 |
| 3 | CYS114 |
| 3 | GLN117 |
| 3 | VAL205 |
| 3 | GLY206 |
| site_id | AC6 |
| Number of Residues | 10 |
| Details | binding site for residue SF4 3 802 |
| Chain | Residue |
| 3 | MET150 |
| 3 | CYS153 |
| 3 | ILE154 |
| 3 | CYS156 |
| 3 | THR157 |
| 3 | CYS159 |
| 3 | VAL183 |
| 3 | CYS203 |
| 3 | VAL205 |
| 3 | ALA207 |
| site_id | AC7 |
| Number of Residues | 9 |
| Details | binding site for residue FES 3 803 |
| Chain | Residue |
| 3 | ARG39 |
| 3 | CYS41 |
| 3 | TYR42 |
| 3 | GLY50 |
| 3 | ASN51 |
| 3 | CYS52 |
| 3 | ARG53 |
| 3 | CYS55 |
| 3 | CYS69 |
| site_id | AC8 |
| Number of Residues | 6 |
| Details | binding site for residue K 3 804 |
| Chain | Residue |
| 3 | GLN110 |
| 3 | ILE200 |
| 3 | CYS203 |
| 3 | VAL205 |
| 3 | LEU208 |
| 3 | HOH1048 |
| site_id | AC9 |
| Number of Residues | 12 |
| Details | binding site for residue SF4 6 201 |
| Chain | Residue |
| 4 | ARG105 |
| 4 | HIS190 |
| 6 | ALA53 |
| 6 | CYS54 |
| 6 | CYS55 |
| 6 | GLY90 |
| 6 | GLY117 |
| 6 | SER118 |
| 6 | CYS119 |
| 6 | CYS149 |
| 6 | PRO150 |
| 4 | 2MR85 |
| site_id | AD1 |
| Number of Residues | 6 |
| Details | binding site for residue PC1 6 202 |
| Chain | Residue |
| 6 | ARG172 |
| 6 | LEU173 |
| 6 | TRP176 |
| 6 | ARG179 |
| 6 | HOH314 |
| d | ASP55 |
| site_id | AD2 |
| Number of Residues | 11 |
| Details | binding site for residue 3PE 6 203 |
| Chain | Residue |
| 6 | TYR28 |
| 6 | ASP35 |
| 6 | TRP39 |
| 6 | ARG42 |
| 6 | LYS168 |
| 6 | HOH305 |
| 6 | HOH309 |
| i | TRP75 |
| i | 3PE201 |
| i | HOH303 |
| i | HOH319 |
| site_id | AD3 |
| Number of Residues | 7 |
| Details | binding site for residue PC1 9 401 |
| Chain | Residue |
| 4 | ARG233 |
| 9 | THR24 |
| 9 | LEU25 |
| 9 | TRP27 |
| 9 | LEU30 |
| 9 | LEU34 |
| 9 | HOH576 |
| site_id | AD4 |
| Number of Residues | 11 |
| Details | binding site for residue SF4 9 402 |
| Chain | Residue |
| 9 | HIS65 |
| 9 | CYS87 |
| 9 | PRO88 |
| 9 | ILE92 |
| 9 | CYS116 |
| 9 | ILE117 |
| 9 | TYR118 |
| 9 | CYS119 |
| 9 | GLY120 |
| 9 | CYS122 |
| 9 | GLU133 |
| site_id | AD5 |
| Number of Residues | 10 |
| Details | binding site for residue SF4 9 403 |
| Chain | Residue |
| 9 | CYS77 |
| 9 | ILE78 |
| 9 | ALA79 |
| 9 | CYS80 |
| 9 | LYS81 |
| 9 | CYS83 |
| 9 | TYR109 |
| 9 | CYS126 |
| 9 | VAL128 |
| 9 | ILE131 |
| site_id | AD6 |
| Number of Residues | 5 |
| Details | binding site for residue ZN b 300 |
| Chain | Residue |
| b | CYS59 |
| b | GLY61 |
| b | HIS68 |
| b | CYS84 |
| b | CYS87 |
| site_id | AD7 |
| Number of Residues | 32 |
| Details | binding site for residue NDP d 401 |
| Chain | Residue |
| 6 | ARG179 |
| d | GLY25 |
| d | THR27 |
| d | GLY28 |
| d | PHE29 |
| d | LEU30 |
| d | ARG50 |
| d | CYS51 |
| d | TRP73 |
| d | LEU94 |
| d | VAL95 |
| d | GLY96 |
| d | ARG97 |
| d | PHE104 |
| d | ILE132 |
| d | SER133 |
| d | HIS134 |
| d | TYR145 |
| d | LYS149 |
| d | PRO168 |
| d | ILE171 |
| d | ARG177 |
| d | HOH525 |
| d | HOH531 |
| d | HOH534 |
| d | HOH540 |
| d | HOH542 |
| d | HOH547 |
| d | HOH553 |
| d | HOH554 |
| d | HOH558 |
| d | HOH562 |
| site_id | AD8 |
| Number of Residues | 11 |
| Details | binding site for residue ZMP g 201 |
| Chain | Residue |
| g | LYS28 |
| g | VAL31 |
| g | TRP38 |
| g | MET65 |
| g | PHE66 |
| g | ASN69 |
| g | ALA70 |
| g | VAL72 |
| g | VAL78 |
| j | SER44 |
| j | LEU45 |
| site_id | AD9 |
| Number of Residues | 11 |
| Details | binding site for residue CDL h 201 |
| Chain | Residue |
| 9 | HOH538 |
| h | SER2 |
| h | ALA3 |
| h | THR4 |
| h | ILE7 |
| h | HOH327 |
| h | HOH330 |
| i | LEU3 |
| i | VAL6 |
| i | ARG9 |
| i | GLN13 |
| site_id | AE1 |
| Number of Residues | 3 |
| Details | binding site for residue 3PE i 201 |
| Chain | Residue |
| 6 | 3PE203 |
| i | PHE74 |
| i | TRP75 |
Functional Information from PROSITE/UniProt
| site_id | PS00012 |
| Number of Residues | 16 |
| Details | PHOSPHOPANTETHEINE Phosphopantetheine attachment site. DLGLDSLDQVEIIMAM |
| Chain | Residue | Details |
| j | ASP39-MET54 |
| site_id | PS00018 |
| Number of Residues | 13 |
| Details | EF_HAND_1 EF-hand calcium-binding domain. DIDAEKLMCpqEI |
| Chain | Residue | Details |
| j | ASP64-ILE76 |
| site_id | PS00198 |
| Number of Residues | 12 |
| Details | 4FE4S_FER_1 4Fe-4S ferredoxin-type iron-sulfur binding region signature. CiACKlCEaVCP |
| Chain | Residue | Details |
| 9 | CYS77-PRO88 | |
| 9 | CYS116-PRO127 |
| site_id | PS00535 |
| Number of Residues | 12 |
| Details | COMPLEX1_49K Respiratory chain NADH dehydrogenase 49 Kd subunit signature. LHRGtEKLiEyK |
| Chain | Residue | Details |
| 4 | LEU83-LYS94 |
| site_id | PS00542 |
| Number of Residues | 22 |
| Details | COMPLEX1_30K Respiratory chain NADH dehydrogenase 30 Kd subunit signature. EREiwDMFgvffanHpdlRrIL |
| Chain | Residue | Details |
| 5 | GLU131-LEU152 |
| site_id | PS00641 |
| Number of Residues | 18 |
| Details | COMPLEX1_75K_1 Respiratory-chain NADH dehydrogenase 75 Kd subunit signature 1. PrfCYherlsvaGnCRmC |
| Chain | Residue | Details |
| 3 | PRO38-CYS55 |
| site_id | PS00642 |
| Number of Residues | 13 |
| Details | COMPLEX1_75K_2 Respiratory-chain NADH dehydrogenase 75 Kd subunit signature 2. CPiCDqGGeCdLQ |
| Chain | Residue | Details |
| 3 | CYS105-GLN117 |
| site_id | PS00643 |
| Number of Residues | 11 |
| Details | COMPLEX1_75K_3 Respiratory-chain NADH dehydrogenase 75 Kd subunit signature 3. RCIqCtRCIrF |
| Chain | Residue | Details |
| 3 | ARG152-PHE162 |
| site_id | PS00644 |
| Number of Residues | 16 |
| Details | COMPLEX1_51K_1 Respiratory-chain NADH dehydrogenase 51 Kd subunit signature 1. GAGAYICGEETALIES |
| Chain | Residue | Details |
| 1 | GLY180-SER195 |
| site_id | PS00645 |
| Number of Residues | 12 |
| Details | COMPLEX1_51K_2 Respiratory-chain NADH dehydrogenase 51 Kd subunit signature 2. ESCGqCtPCReG |
| Chain | Residue | Details |
| 1 | GLU357-GLY368 |
| site_id | PS01099 |
| Number of Residues | 19 |
| Details | COMPLEX1_24K Respiratory-chain NADH dehydrogenase 24 Kd subunit signature. DklFTlieveCLGaCvnAP |
| Chain | Residue | Details |
| 2 | ASP134-PRO152 |
| site_id | PS01150 |
| Number of Residues | 17 |
| Details | COMPLEX1_20K Respiratory-chain NADH dehydrogenase 20 Kd subunit signature. GcDRIVPVDIYvPgCPP |
| Chain | Residue | Details |
| 6 | GLY135-PRO151 |
