Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

6ZK9

Peripheral domain of open complex I during turnover

Functional Information from GO Data

Chain	GOid	namespace	contents
1	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
1	0010181	molecular_function	FMN binding
1	0051287	molecular_function	NAD binding
1	0051539	molecular_function	4 iron, 4 sulfur cluster binding
2	0016491	molecular_function	oxidoreductase activity
3	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
3	0016020	cellular_component	membrane
3	0016491	molecular_function	oxidoreductase activity
3	0016651	molecular_function	oxidoreductase activity, acting on NAD(P)H
3	0042773	biological_process	ATP synthesis coupled electron transport
3	0051536	molecular_function	iron-sulfur cluster binding
4	0016651	molecular_function	oxidoreductase activity, acting on NAD(P)H
4	0048038	molecular_function	quinone binding
4	0051287	molecular_function	NAD binding
5	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
5	0016651	molecular_function	oxidoreductase activity, acting on NAD(P)H
6	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
6	0048038	molecular_function	quinone binding
6	0051536	molecular_function	iron-sulfur cluster binding
6	0051539	molecular_function	4 iron, 4 sulfur cluster binding
9	0016020	cellular_component	membrane
9	0016651	molecular_function	oxidoreductase activity, acting on NAD(P)H
9	0051539	molecular_function	4 iron, 4 sulfur cluster binding
a	0005739	cellular_component	mitochondrion
a	0045271	cellular_component	respiratory chain complex I
b	0006120	biological_process	mitochondrial electron transport, NADH to ubiquinone
c	0022900	biological_process	electron transport chain
f	0022904	biological_process	respiratory electron transport chain
g	0045271	cellular_component	respiratory chain complex I
h	0005743	cellular_component	mitochondrial inner membrane
h	0042773	biological_process	ATP synthesis coupled electron transport
i	0016020	cellular_component	membrane
i	0045271	cellular_component	respiratory chain complex I
j	0006633	biological_process	fatty acid biosynthetic process

Functional Information from PDB Data

site_id	AC1
Number of Residues	12
Details	binding site for residue SF4 1 501

Chain	Residue
1	ILE185
1	ILE404
1	CYS405
1	LEU407
1	PRO203
1	SER358
1	CYS359
1	GLY360
1	GLN361
1	CYS362
1	CYS365
1	THR403

site_id	AC2
Number of Residues	23
Details	binding site for residue FMN 1 502

Chain	Residue
1	GLY67
1	ARG68
1	GLY69
1	LYS78
1	ASN96
1	ASP98
1	GLU99
1	GLY100
1	GLY187
1	GLU188
1	GLU189
1	VAL222
1	ALA223
1	ASN224
1	THR227
1	LEU407
1	NAI503
1	HOH607
1	HOH622
1	HOH636
1	HOH652
1	HOH663
1	HOH682

site_id	AC3
Number of Residues	20
Details	binding site for residue NAI 1 503

Chain	Residue
1	GLY69
1	GLY70
1	ALA71
1	PHE73
1	LYS78
1	PHE81
1	GLU99
1	GLU101
1	TYR184
1	GLU189
1	PHE209
1	SER303
1	GLY330
1	THR331
1	FMN502
1	HOH602
1	HOH603
1	HOH611
1	HOH628
1	HOH671

site_id	AC4
Number of Residues	9
Details	binding site for residue FES 2 300

Chain	Residue
2	CYS103
2	THR105
2	PRO107
2	CYS108
2	CYS144
2	LEU145
2	GLY146
2	ALA147
2	CYS148

site_id	AC5
Number of Residues	9
Details	binding site for residue SF4 3 801

Chain	Residue
3	HIS101
3	ASP104
3	CYS105
3	CYS108
3	GLY111
3	CYS114
3	GLN117
3	VAL205
3	GLY206

site_id	AC6
Number of Residues	10
Details	binding site for residue SF4 3 802

Chain	Residue
3	MET150
3	CYS153
3	ILE154
3	CYS156
3	THR157
3	CYS159
3	VAL183
3	CYS203
3	VAL205
3	ALA207

site_id	AC7
Number of Residues	9
Details	binding site for residue FES 3 803

Chain	Residue
3	ARG39
3	CYS41
3	TYR42
3	GLY50
3	ASN51
3	CYS52
3	ARG53
3	CYS55
3	CYS69

site_id	AC8
Number of Residues	6
Details	binding site for residue K 3 804

Chain	Residue
3	GLN110
3	ILE200
3	CYS203
3	VAL205
3	LEU208
3	HOH1048

site_id	AC9
Number of Residues	12
Details	binding site for residue SF4 6 201

Chain	Residue
4	ARG105
4	HIS190
6	ALA53
6	CYS54
6	CYS55
6	GLY90
6	GLY117
6	SER118
6	CYS119
6	CYS149
6	PRO150
4	2MR85

site_id	AD1
Number of Residues	6
Details	binding site for residue PC1 6 202

Chain	Residue
6	ARG172
6	LEU173
6	TRP176
6	ARG179
6	HOH314
d	ASP55

site_id	AD2
Number of Residues	11
Details	binding site for residue 3PE 6 203

Chain	Residue
6	TYR28
6	ASP35
6	TRP39
6	ARG42
6	LYS168
6	HOH305
6	HOH309
i	TRP75
i	3PE201
i	HOH303
i	HOH319

site_id	AD3
Number of Residues	7
Details	binding site for residue PC1 9 401

Chain	Residue
4	ARG233
9	THR24
9	LEU25
9	TRP27
9	LEU30
9	LEU34
9	HOH576

site_id	AD4
Number of Residues	11
Details	binding site for residue SF4 9 402

Chain	Residue
9	HIS65
9	CYS87
9	PRO88
9	ILE92
9	CYS116
9	ILE117
9	TYR118
9	CYS119
9	GLY120
9	CYS122
9	GLU133

site_id	AD5
Number of Residues	10
Details	binding site for residue SF4 9 403

Chain	Residue
9	CYS77
9	ILE78
9	ALA79
9	CYS80
9	LYS81
9	CYS83
9	TYR109
9	CYS126
9	VAL128
9	ILE131

site_id	AD6
Number of Residues	5
Details	binding site for residue ZN b 300

Chain	Residue
b	CYS59
b	GLY61
b	HIS68
b	CYS84
b	CYS87

site_id	AD7
Number of Residues	32
Details	binding site for residue NDP d 401

Chain	Residue
6	ARG179
d	GLY25
d	THR27
d	GLY28
d	PHE29
d	LEU30
d	ARG50
d	CYS51
d	TRP73
d	LEU94
d	VAL95
d	GLY96
d	ARG97
d	PHE104
d	ILE132
d	SER133
d	HIS134
d	TYR145
d	LYS149
d	PRO168
d	ILE171
d	ARG177
d	HOH525
d	HOH531
d	HOH534
d	HOH540
d	HOH542
d	HOH547
d	HOH553
d	HOH554
d	HOH558
d	HOH562

site_id	AD8
Number of Residues	11
Details	binding site for residue ZMP g 201

Chain	Residue
g	LYS28
g	VAL31
g	TRP38
g	MET65
g	PHE66
g	ASN69
g	ALA70
g	VAL72
g	VAL78
j	SER44
j	LEU45

site_id	AD9
Number of Residues	11
Details	binding site for residue CDL h 201

Chain	Residue
9	HOH538
h	SER2
h	ALA3
h	THR4
h	ILE7
h	HOH327
h	HOH330
i	LEU3
i	VAL6
i	ARG9
i	GLN13

site_id	AE1
Number of Residues	3
Details	binding site for residue 3PE i 201

Chain	Residue
6	3PE203
i	PHE74
i	TRP75

Functional Information from PROSITE/UniProt

site_id	PS00012
Number of Residues	16
Details	PHOSPHOPANTETHEINE Phosphopantetheine attachment site. DLGLDSLDQVEIIMAM

Chain	Residue	Details
j	ASP39-MET54

site_id	PS00018
Number of Residues	13
Details	EF_HAND_1 EF-hand calcium-binding domain. DIDAEKLMCpqEI

Chain	Residue	Details
j	ASP64-ILE76

site_id	PS00198
Number of Residues	12
Details	4FE4S_FER_1 4Fe-4S ferredoxin-type iron-sulfur binding region signature. CiACKlCEaVCP

Chain	Residue	Details
9	CYS77-PRO88
9	CYS116-PRO127

site_id	PS00535
Number of Residues	12
Details	COMPLEX1_49K Respiratory chain NADH dehydrogenase 49 Kd subunit signature. LHRGtEKLiEyK

Chain	Residue	Details
4	LEU83-LYS94

site_id	PS00542
Number of Residues	22
Details	COMPLEX1_30K Respiratory chain NADH dehydrogenase 30 Kd subunit signature. EREiwDMFgvffanHpdlRrIL

Chain	Residue	Details
5	GLU131-LEU152

site_id	PS00641
Number of Residues	18
Details	COMPLEX1_75K_1 Respiratory-chain NADH dehydrogenase 75 Kd subunit signature 1. PrfCYherlsvaGnCRmC

Chain	Residue	Details
3	PRO38-CYS55

site_id	PS00642
Number of Residues	13
Details	COMPLEX1_75K_2 Respiratory-chain NADH dehydrogenase 75 Kd subunit signature 2. CPiCDqGGeCdLQ

Chain	Residue	Details
3	CYS105-GLN117

site_id	PS00643
Number of Residues	11
Details	COMPLEX1_75K_3 Respiratory-chain NADH dehydrogenase 75 Kd subunit signature 3. RCIqCtRCIrF

Chain	Residue	Details
3	ARG152-PHE162

site_id	PS00644
Number of Residues	16
Details	COMPLEX1_51K_1 Respiratory-chain NADH dehydrogenase 51 Kd subunit signature 1. GAGAYICGEETALIES

Chain	Residue	Details
1	GLY180-SER195

site_id	PS00645
Number of Residues	12
Details	COMPLEX1_51K_2 Respiratory-chain NADH dehydrogenase 51 Kd subunit signature 2. ESCGqCtPCReG

Chain	Residue	Details
1	GLU357-GLY368

site_id	PS01099
Number of Residues	19
Details	COMPLEX1_24K Respiratory-chain NADH dehydrogenase 24 Kd subunit signature. DklFTlieveCLGaCvnAP

Chain	Residue	Details
2	ASP134-PRO152

site_id	PS01150
Number of Residues	17
Details	COMPLEX1_20K Respiratory-chain NADH dehydrogenase 20 Kd subunit signature. GcDRIVPVDIYvPgCPP

Chain	Residue	Details
6	GLY135-PRO151

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)