6ZK0

1.47A human IMPase with ebselen

This is a non-PDB format compatible entry.

Functional Information from GO Data

Chain	GOid	namespace	contents
AAA	0000287	molecular_function	magnesium ion binding
AAA	0005515	molecular_function	protein binding
AAA	0005737	cellular_component	cytoplasm
AAA	0005829	cellular_component	cytosol
AAA	0006020	biological_process	inositol metabolic process
AAA	0006021	biological_process	inositol biosynthetic process
AAA	0006661	biological_process	phosphatidylinositol biosynthetic process
AAA	0006796	biological_process	phosphate-containing compound metabolic process
AAA	0007165	biological_process	signal transduction
AAA	0008934	molecular_function	inositol monophosphate 1-phosphatase activity
AAA	0016787	molecular_function	hydrolase activity
AAA	0030145	molecular_function	manganese ion binding
AAA	0031403	molecular_function	lithium ion binding
AAA	0042802	molecular_function	identical protein binding
AAA	0042803	molecular_function	protein homodimerization activity
AAA	0046854	biological_process	phosphatidylinositol phosphate biosynthetic process
AAA	0046872	molecular_function	metal ion binding
AAA	0052832	molecular_function	inositol monophosphate 3-phosphatase activity
AAA	0052833	molecular_function	inositol monophosphate 4-phosphatase activity
AAA	0052834	molecular_function	inositol monophosphate phosphatase activity
BBB	0000287	molecular_function	magnesium ion binding
BBB	0005515	molecular_function	protein binding
BBB	0005737	cellular_component	cytoplasm
BBB	0005829	cellular_component	cytosol
BBB	0006020	biological_process	inositol metabolic process
BBB	0006021	biological_process	inositol biosynthetic process
BBB	0006661	biological_process	phosphatidylinositol biosynthetic process
BBB	0006796	biological_process	phosphate-containing compound metabolic process
BBB	0007165	biological_process	signal transduction
BBB	0008934	molecular_function	inositol monophosphate 1-phosphatase activity
BBB	0016787	molecular_function	hydrolase activity
BBB	0030145	molecular_function	manganese ion binding
BBB	0031403	molecular_function	lithium ion binding
BBB	0042802	molecular_function	identical protein binding
BBB	0042803	molecular_function	protein homodimerization activity
BBB	0046854	biological_process	phosphatidylinositol phosphate biosynthetic process
BBB	0046872	molecular_function	metal ion binding
BBB	0052832	molecular_function	inositol monophosphate 3-phosphatase activity
BBB	0052833	molecular_function	inositol monophosphate 4-phosphatase activity
BBB	0052834	molecular_function	inositol monophosphate phosphatase activity

Functional Information from PROSITE/UniProt

site_id	PS00629
Number of Residues	14
Details	IMP_1 Inositol monophosphatase family signature 1. WiIDPIDGTtnFvH

Chain	Residue	Details
AAA	TRP87-HIS100

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site_id	PS00630
Number of Residues	15
Details	IMP_2 Inositol monophosphatase family signature 2. WDvAGAgIIVteaGG

Chain	Residue	Details
AAA	TRP219-GLY233

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	BINDING: BINDING => ECO:0000269|PubMed:8068620, ECO:0000303|PubMed:8068621

Chain	Residue	Details
BBB	GLU70
BBB	GLU213
AAA	GLU70
AAA	GLU213

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site_id	SWS_FT_FI2
Number of Residues	4
Details	BINDING: BINDING => ECO:0000269|PubMed:23027737, ECO:0000269|PubMed:8068621

Chain	Residue	Details
AAA	ASP90
AAA	ASP93
BBB	ASP90
BBB	ASP93

---

site_id	SWS_FT_FI3
Number of Residues	2
Details	BINDING: BINDING => ECO:0000269|PubMed:23027737, ECO:0000269|PubMed:8068621, ECO:0000303|PubMed:1332026, ECO:0000303|PubMed:8068620

Chain	Residue	Details
AAA	ILE92
BBB	ILE92

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site_id	SWS_FT_FI4
Number of Residues	4
Details	BINDING: BINDING => ECO:0000269|PubMed:8068620

Chain	Residue	Details
AAA	GLY194
AAA	ASP220
BBB	GLY194
BBB	ASP220

---

site_id	SWS_FT_FI5
Number of Residues	2
Details	MOD_RES: Phosphothreonine => ECO:0007744|PubMed:23186163

Chain	Residue	Details
AAA	THR168
BBB	THR168

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Catalytic Information from CSA

site_id	MCSA1
Number of Residues	6
Details	M-CSA 577

Chain	Residue	Details
AAA	GLU70	metal ligand, proton acceptor, proton donor
AAA	ASP90	metal ligand
AAA	ILE92	metal ligand
AAA	ASP93	metal ligand
AAA	THR95	hydrogen bond acceptor
AAA	ASP220	metal ligand

---

site_id	MCSA2
Number of Residues	6
Details	M-CSA 577

Chain	Residue	Details
BBB	GLU70	metal ligand, proton acceptor, proton donor
BBB	ASP90	metal ligand
BBB	ILE92	metal ligand
BBB	ASP93	metal ligand
BBB	THR95	hydrogen bond acceptor
BBB	ASP220	metal ligand

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