6ZK0

1.47A human IMPase with ebselen

This is a non-PDB format compatible entry.

Functional Information from GO Data

Chain	GOid	namespace	contents
AAA	0000287	molecular_function	magnesium ion binding
AAA	0004346	molecular_function	glucose-6-phosphatase activity
AAA	0005515	molecular_function	protein binding
AAA	0005737	cellular_component	cytoplasm
AAA	0005829	cellular_component	cytosol
AAA	0006020	biological_process	inositol metabolic process
AAA	0006021	biological_process	inositol biosynthetic process
AAA	0006661	biological_process	phosphatidylinositol biosynthetic process
AAA	0006796	biological_process	phosphate-containing compound metabolic process
AAA	0007165	biological_process	signal transduction
AAA	0008877	molecular_function	glucose-1-phosphatase activity
AAA	0008934	molecular_function	inositol monophosphate 1-phosphatase activity
AAA	0016787	molecular_function	hydrolase activity
AAA	0030145	molecular_function	manganese ion binding
AAA	0031403	molecular_function	lithium ion binding
AAA	0042802	molecular_function	identical protein binding
AAA	0042803	molecular_function	protein homodimerization activity
AAA	0046854	biological_process	phosphatidylinositol phosphate biosynthetic process
AAA	0046872	molecular_function	metal ion binding
AAA	0047954	molecular_function	glycerol-2-phosphatase activity
AAA	0052832	molecular_function	inositol monophosphate 3-phosphatase activity
AAA	0052833	molecular_function	inositol monophosphate 4-phosphatase activity
AAA	0052834	molecular_function	inositol monophosphate phosphatase activity
AAA	0103026	molecular_function	fructose-1-phosphatase activity
BBB	0000287	molecular_function	magnesium ion binding
BBB	0004346	molecular_function	glucose-6-phosphatase activity
BBB	0005515	molecular_function	protein binding
BBB	0005737	cellular_component	cytoplasm
BBB	0005829	cellular_component	cytosol
BBB	0006020	biological_process	inositol metabolic process
BBB	0006021	biological_process	inositol biosynthetic process
BBB	0006661	biological_process	phosphatidylinositol biosynthetic process
BBB	0006796	biological_process	phosphate-containing compound metabolic process
BBB	0007165	biological_process	signal transduction
BBB	0008877	molecular_function	glucose-1-phosphatase activity
BBB	0008934	molecular_function	inositol monophosphate 1-phosphatase activity
BBB	0016787	molecular_function	hydrolase activity
BBB	0030145	molecular_function	manganese ion binding
BBB	0031403	molecular_function	lithium ion binding
BBB	0042802	molecular_function	identical protein binding
BBB	0042803	molecular_function	protein homodimerization activity
BBB	0046854	biological_process	phosphatidylinositol phosphate biosynthetic process
BBB	0046872	molecular_function	metal ion binding
BBB	0047954	molecular_function	glycerol-2-phosphatase activity
BBB	0052832	molecular_function	inositol monophosphate 3-phosphatase activity
BBB	0052833	molecular_function	inositol monophosphate 4-phosphatase activity
BBB	0052834	molecular_function	inositol monophosphate phosphatase activity
BBB	0103026	molecular_function	fructose-1-phosphatase activity

Functional Information from PROSITE/UniProt

site_id	PS00629
Number of Residues	14
Details	IMP_1 Inositol monophosphatase family signature 1. WiIDPIDGTtnFvH

Chain	Residue	Details
AAA	TRP87-HIS100

---

site_id	PS00630
Number of Residues	15
Details	IMP_2 Inositol monophosphatase family signature 2. WDvAGAgIIVteaGG

Chain	Residue	Details
AAA	TRP219-GLY233

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	10
Details	Binding site: {"evidences":[{"source":"PubMed","id":"8068620","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"8068621","evidenceCode":"ECO:0000303"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"PubMed","id":"23027737","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"8068621","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"23027737","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"8068621","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"1332026","evidenceCode":"ECO:0000303"},{"source":"PubMed","id":"8068620","evidenceCode":"ECO:0000303"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	6
Details	Binding site: {"evidences":[{"source":"PubMed","id":"8068620","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	2
Details	Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

Catalytic Information from CSA

site_id	MCSA1
Number of Residues	6
Details	M-CSA 577

Chain

Residue

Details

---

site_id	MCSA2
Number of Residues	6
Details	M-CSA 577

Chain

Residue

Details

---