Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

6ZJY

Respiratory complex I from Thermus thermophilus, NAD+ dataset, minor state

Functional Information from GO Data

Chain	GOid	namespace	contents
1	0005886	cellular_component	plasma membrane
1	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
1	0010181	molecular_function	FMN binding
1	0046872	molecular_function	metal ion binding
1	0048038	molecular_function	quinone binding
1	0051287	molecular_function	NAD binding
1	0051539	molecular_function	4 iron, 4 sulfur cluster binding
1	1902600	biological_process	proton transmembrane transport
2	0003954	molecular_function	NADH dehydrogenase activity
2	0005886	cellular_component	plasma membrane
2	0016491	molecular_function	oxidoreductase activity
2	0046872	molecular_function	metal ion binding
2	0048038	molecular_function	quinone binding
2	0051537	molecular_function	2 iron, 2 sulfur cluster binding
3	0005886	cellular_component	plasma membrane
3	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
3	0016020	cellular_component	membrane
3	0016491	molecular_function	oxidoreductase activity
3	0016651	molecular_function	oxidoreductase activity, acting on NAD(P)H
3	0042773	biological_process	ATP synthesis coupled electron transport
3	0043546	molecular_function	molybdopterin cofactor binding
3	0046872	molecular_function	metal ion binding
3	0048038	molecular_function	quinone binding
3	0051536	molecular_function	iron-sulfur cluster binding
3	0051537	molecular_function	2 iron, 2 sulfur cluster binding
3	0051539	molecular_function	4 iron, 4 sulfur cluster binding
3	1902600	biological_process	proton transmembrane transport
4	0005886	cellular_component	plasma membrane
4	0016651	molecular_function	oxidoreductase activity, acting on NAD(P)H
4	0048038	molecular_function	quinone binding
4	0050136	molecular_function	NADH:ubiquinone reductase (non-electrogenic) activity
4	0051287	molecular_function	NAD binding
5	0005886	cellular_component	plasma membrane
5	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
5	0016651	molecular_function	oxidoreductase activity, acting on NAD(P)H
5	0048038	molecular_function	quinone binding
5	0050136	molecular_function	NADH:ubiquinone reductase (non-electrogenic) activity
5	1902600	biological_process	proton transmembrane transport
6	0005506	molecular_function	iron ion binding
6	0005886	cellular_component	plasma membrane
6	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
6	0009060	biological_process	aerobic respiration
6	0015990	biological_process	electron transport coupled proton transport
6	0045271	cellular_component	respiratory chain complex I
6	0046872	molecular_function	metal ion binding
6	0048038	molecular_function	quinone binding
6	0050136	molecular_function	NADH:ubiquinone reductase (non-electrogenic) activity
6	0051536	molecular_function	iron-sulfur cluster binding
6	0051539	molecular_function	4 iron, 4 sulfur cluster binding
7	0005886	cellular_component	plasma membrane
7	0008199	molecular_function	ferric iron binding
7	0016226	biological_process	iron-sulfur cluster assembly
7	0048038	molecular_function	quinone binding
9	0003954	molecular_function	NADH dehydrogenase activity
9	0005506	molecular_function	iron ion binding
9	0005886	cellular_component	plasma membrane
9	0009060	biological_process	aerobic respiration
9	0016020	cellular_component	membrane
9	0016651	molecular_function	oxidoreductase activity, acting on NAD(P)H
9	0046872	molecular_function	metal ion binding
9	0048038	molecular_function	quinone binding
9	0050136	molecular_function	NADH:ubiquinone reductase (non-electrogenic) activity
9	0051539	molecular_function	4 iron, 4 sulfur cluster binding
A	0005886	cellular_component	plasma membrane
A	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
A	0016651	molecular_function	oxidoreductase activity, acting on NAD(P)H
A	0030964	cellular_component	NADH dehydrogenase complex
A	0048038	molecular_function	quinone binding
A	0050136	molecular_function	NADH:ubiquinone reductase (non-electrogenic) activity
A	1902600	biological_process	proton transmembrane transport
H	0003954	molecular_function	NADH dehydrogenase activity
H	0005886	cellular_component	plasma membrane
H	0009060	biological_process	aerobic respiration
H	0016020	cellular_component	membrane
H	0016655	molecular_function	oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor
H	0048038	molecular_function	quinone binding
J	0005886	cellular_component	plasma membrane
J	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
J	0048038	molecular_function	quinone binding
J	1902600	biological_process	proton transmembrane transport
K	0005886	cellular_component	plasma membrane
K	0016651	molecular_function	oxidoreductase activity, acting on NAD(P)H
K	0030964	cellular_component	NADH dehydrogenase complex
K	0042773	biological_process	ATP synthesis coupled electron transport
K	0048038	molecular_function	quinone binding
K	0050136	molecular_function	NADH:ubiquinone reductase (non-electrogenic) activity
L	0003954	molecular_function	NADH dehydrogenase activity
L	0005886	cellular_component	plasma membrane
L	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
L	0015990	biological_process	electron transport coupled proton transport
L	0042773	biological_process	ATP synthesis coupled electron transport
L	0048038	molecular_function	quinone binding
M	0003954	molecular_function	NADH dehydrogenase activity
M	0005886	cellular_component	plasma membrane
M	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
M	0009060	biological_process	aerobic respiration
M	0015990	biological_process	electron transport coupled proton transport
M	0042773	biological_process	ATP synthesis coupled electron transport
M	0048038	molecular_function	quinone binding
M	0048039	molecular_function	ubiquinone binding
N	0005886	cellular_component	plasma membrane
N	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
N	0042773	biological_process	ATP synthesis coupled electron transport
N	0048038	molecular_function	quinone binding
N	0050136	molecular_function	NADH:ubiquinone reductase (non-electrogenic) activity
N	1902600	biological_process	proton transmembrane transport

Functional Information from PDB Data

site_id	AC1
Number of Residues	7
Details	binding site for residue SF4 1 501

Chain	Residue
1	CYS353
1	GLY354
1	LYS355
1	CYS356
1	THR357
1	PHE399
1	CYS400

site_id	AC2
Number of Residues	8
Details	binding site for residue FES 2 201

Chain	Residue
2	SER87
2	CYS88
2	LEU125
2	GLY126
2	SER127
2	CYS128
2	CYS83
2	THR85

site_id	AC3
Number of Residues	7
Details	binding site for residue SF4 3 801

Chain	Residue
3	ASP118
3	CYS119
3	CYS122
3	LYS124
3	GLY125
3	CYS128
3	GLY233

site_id	AC4
Number of Residues	7
Details	binding site for residue SF4 3 802

Chain	Residue
3	CYS181
3	ILE182
3	HIS183
3	CYS184
3	LYS185
3	ARG186
3	CYS230

site_id	AC5
Number of Residues	6
Details	binding site for residue SF4 3 803

Chain	Residue
3	CYS256
3	LEU258
3	CYS259
3	VAL261
3	GLY262
3	CYS263

site_id	AC6
Number of Residues	7
Details	binding site for residue FES 3 804

Chain	Residue
3	CYS34
3	SER35
3	ILE42
3	GLY43
3	CYS45
3	ARG46
3	CYS83

site_id	AC7
Number of Residues	5
Details	binding site for residue SF4 6 201

Chain	Residue
6	ALA44
6	ALA110
6	CYS111
6	CYS140
6	PRO141

site_id	AC8
Number of Residues	6
Details	binding site for residue SF4 9 201

Chain	Residue
9	CYS63
9	CYS98
9	ILE99
9	PHE100
9	CYS101
9	CYS104

site_id	AC9
Number of Residues	8
Details	binding site for residue SF4 9 202

Chain	Residue
9	CYS53
9	ILE54
9	GLY55
9	CYS56
9	SER57
9	CYS108
9	THR110
9	ALA112

Functional Information from PROSITE/UniProt

site_id	PS00198
Number of Residues	12
Details	4FE4S_FER_1 4Fe-4S ferredoxin-type iron-sulfur binding region signature. CiGCSlCAaACP

Chain	Residue	Details
9	CYS53-PRO64
9	CYS98-PRO109

site_id	PS00535
Number of Residues	12
Details	COMPLEX1_49K Respiratory chain NADH dehydrogenase 49 Kd subunit signature. LHTGfEKTmEhR

Chain	Residue	Details
4	LEU62-ARG73

site_id	PS00542
Number of Residues	22
Details	COMPLEX1_30K Respiratory chain NADH dehydrogenase 30 Kd subunit signature. EREvyDLFgivfegHpdlRkIL

Chain	Residue	Details
5	GLU115-LEU136

site_id	PS00641
Number of Residues	18
Details	COMPLEX1_75K_1 Respiratory-chain NADH dehydrogenase 75 Kd subunit signature 1. PlfCSekhlspiGaCRmC

Chain	Residue	Details
3	PRO31-CYS48

site_id	PS00642
Number of Residues	13
Details	COMPLEX1_75K_2 Respiratory-chain NADH dehydrogenase 75 Kd subunit signature 2. CPtCDkGGaCeLQ

Chain	Residue	Details
3	CYS119-GLN131

site_id	PS00643
Number of Residues	11
Details	COMPLEX1_75K_3 Respiratory-chain NADH dehydrogenase 75 Kd subunit signature 3. RCIhCkRCVrY

Chain	Residue	Details
3	ARG180-TYR190

site_id	PS00644
Number of Residues	16
Details	COMPLEX1_51K_1 Respiratory-chain NADH dehydrogenase 51 Kd subunit signature 1. GAGAYICGEETALMNS

Chain	Residue	Details
1	GLY176-SER191

site_id	PS00645
Number of Residues	12
Details	COMPLEX1_51K_2 Respiratory-chain NADH dehydrogenase 51 Kd subunit signature 2. ESCGkCtPCReG

Chain	Residue	Details
1	GLU351-GLY362

site_id	PS00667
Number of Residues	16
Details	COMPLEX1_ND1_1 Respiratory-chain NADH dehydrogenase subunit 1 signature 1. GLLQpLaDAIKSIfKE

Chain	Residue	Details
H	GLY55-GLU70

site_id	PS00668
Number of Residues	14
Details	COMPLEX1_ND1_2 Respiratory-chain NADH dehydrogenase subunit 1 signature 2. PFDLPEAEqeLVg.G

Chain	Residue	Details
H	PRO218-GLY231

site_id	PS01099
Number of Residues	19
Details	COMPLEX1_24K Respiratory-chain NADH dehydrogenase 24 Kd subunit signature. DglFSvqkveCLGsChtAP

Chain	Residue	Details
2	ASP114-PRO132

site_id	PS01150
Number of Residues	17
Details	COMPLEX1_20K Respiratory-chain NADH dehydrogenase 20 Kd subunit signature. NvDSVVPVDVYvPgCPP

Chain	Residue	Details
6	ASN126-PRO142

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	180
Details	TRANSMEM: Helical => ECO:0000255

Chain	Residue	Details
H	TRP11-MET31
N	LEU257-ASN277
N	ALA280-SER300
N	LEU322-PHE342
N	VAL360-LEU380
N	ALA400-LEU420
L	GLY492-PHE512
L	GLY584-MET604
H	PHE80-ILE100
H	LEU120-GLY140
H	ALA157-VAL177
H	HIS192-ALA212
H	PHE252-LEU272
H	GLU273-ILE293
H	TRP310-LEU330
H	TYR336-PRO356

site_id	SWS_FT_FI2
Number of Residues	1
Details	BINDING: BINDING => ECO:0000255\|PROSITE-ProRule:PRU01184, ECO:0000269\|PubMed:16469879

Chain	Residue	Details
3	HIS115
1	ASN92
1	TYR180
1	ILE218
1	CYS353
1	CYS356
1	CYS359
1	CYS400

site_id	SWS_FT_FI3
Number of Residues	3
Details	BINDING: BINDING => ECO:0000255\|PROSITE-ProRule:PRU01184

Chain	Residue	Details
3	CYS119
3	CYS122
3	CYS128

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)