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6ZJL

Respiratory complex I from Thermus thermophilus, NAD+ dataset, major state

Functional Information from GO Data
ChainGOidnamespacecontents
10005886cellular_componentplasma membrane
10008137molecular_functionNADH dehydrogenase (ubiquinone) activity
10010181molecular_functionFMN binding
10045271cellular_componentrespiratory chain complex I
10046872molecular_functionmetal ion binding
10048038molecular_functionquinone binding
10051287molecular_functionNAD binding
10051539molecular_function4 iron, 4 sulfur cluster binding
11902600biological_processproton transmembrane transport
20005886cellular_componentplasma membrane
20016491molecular_functionoxidoreductase activity
20045271cellular_componentrespiratory chain complex I
20046872molecular_functionmetal ion binding
20048038molecular_functionquinone binding
20051537molecular_function2 iron, 2 sulfur cluster binding
30005886cellular_componentplasma membrane
30008137molecular_functionNADH dehydrogenase (ubiquinone) activity
30016020cellular_componentmembrane
30016491molecular_functionoxidoreductase activity
30016651molecular_functionoxidoreductase activity, acting on NAD(P)H
30042773biological_processATP synthesis coupled electron transport
30043546molecular_functionmolybdopterin cofactor binding
30046872molecular_functionmetal ion binding
30048038molecular_functionquinone binding
30051536molecular_functioniron-sulfur cluster binding
30051537molecular_function2 iron, 2 sulfur cluster binding
30051539molecular_function4 iron, 4 sulfur cluster binding
31902600biological_processproton transmembrane transport
40005886cellular_componentplasma membrane
40016651molecular_functionoxidoreductase activity, acting on NAD(P)H
40048038molecular_functionquinone binding
40050136molecular_functionNADH:ubiquinone reductase (non-electrogenic) activity
40051287molecular_functionNAD binding
50005886cellular_componentplasma membrane
50008137molecular_functionNADH dehydrogenase (ubiquinone) activity
50016651molecular_functionoxidoreductase activity, acting on NAD(P)H
50048038molecular_functionquinone binding
50050136molecular_functionNADH:ubiquinone reductase (non-electrogenic) activity
51902600biological_processproton transmembrane transport
60005506molecular_functioniron ion binding
60005886cellular_componentplasma membrane
60008137molecular_functionNADH dehydrogenase (ubiquinone) activity
60046872molecular_functionmetal ion binding
60048038molecular_functionquinone binding
60050136molecular_functionNADH:ubiquinone reductase (non-electrogenic) activity
60051536molecular_functioniron-sulfur cluster binding
60051539molecular_function4 iron, 4 sulfur cluster binding
61902600biological_processproton transmembrane transport
70005886cellular_componentplasma membrane
70008199molecular_functionferric iron binding
70016226biological_processiron-sulfur cluster assembly
70048038molecular_functionquinone binding
90005506molecular_functioniron ion binding
90005886cellular_componentplasma membrane
90016020cellular_componentmembrane
90016651molecular_functionoxidoreductase activity, acting on NAD(P)H
90046872molecular_functionmetal ion binding
90048038molecular_functionquinone binding
90050136molecular_functionNADH:ubiquinone reductase (non-electrogenic) activity
90051539molecular_function4 iron, 4 sulfur cluster binding
A0005886cellular_componentplasma membrane
A0008137molecular_functionNADH dehydrogenase (ubiquinone) activity
A0016651molecular_functionoxidoreductase activity, acting on NAD(P)H
A0048038molecular_functionquinone binding
A0050136molecular_functionNADH:ubiquinone reductase (non-electrogenic) activity
A1902600biological_processproton transmembrane transport
H0005886cellular_componentplasma membrane
H0016020cellular_componentmembrane
H0016655molecular_functionoxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor
H0048038molecular_functionquinone binding
J0005886cellular_componentplasma membrane
J0008137molecular_functionNADH dehydrogenase (ubiquinone) activity
J0048038molecular_functionquinone binding
J1902600biological_processproton transmembrane transport
K0005886cellular_componentplasma membrane
K0016651molecular_functionoxidoreductase activity, acting on NAD(P)H
K0042773biological_processATP synthesis coupled electron transport
K0048038molecular_functionquinone binding
K0050136molecular_functionNADH:ubiquinone reductase (non-electrogenic) activity
L0005886cellular_componentplasma membrane
L0008137molecular_functionNADH dehydrogenase (ubiquinone) activity
L0042773biological_processATP synthesis coupled electron transport
L0048038molecular_functionquinone binding
L1902600biological_processproton transmembrane transport
M0005886cellular_componentplasma membrane
M0008137molecular_functionNADH dehydrogenase (ubiquinone) activity
M0042773biological_processATP synthesis coupled electron transport
M0048038molecular_functionquinone binding
M1902600biological_processproton transmembrane transport
N0005886cellular_componentplasma membrane
N0008137molecular_functionNADH dehydrogenase (ubiquinone) activity
N0042773biological_processATP synthesis coupled electron transport
N0048038molecular_functionquinone binding
N0050136molecular_functionNADH:ubiquinone reductase (non-electrogenic) activity
N1902600biological_processproton transmembrane transport
Functional Information from PDB Data
site_idAC1
Number of Residues8
Detailsbinding site for residue SF4 1 501
ChainResidue
1SER352
1CYS353
1GLY354
1LYS355
1CYS356
1CYS359
1CYS400
1LEU402

site_idAC2
Number of Residues12
Detailsbinding site for residue FMN 1 502
ChainResidue
1ARG65
1GLY66
1ASN92
1ASP94
1GLY183
1GLU184
1GLU185
1ASN219
1ASN220
1THR223
1PRO401
1GLY64

site_idAC3
Number of Residues8
Detailsbinding site for residue FES 2 201
ChainResidue
2CYS83
2THR85
2CYS88
2CYS124
2LEU125
2GLY126
2SER127
2CYS128

site_idAC4
Number of Residues7
Detailsbinding site for residue SF4 3 801
ChainResidue
3HIS115
3ASP118
3CYS119
3CYS122
3CYS128
3GLN131
3GLY233

site_idAC5
Number of Residues8
Detailsbinding site for residue SF4 3 802
ChainResidue
3CYS181
3ILE182
3CYS184
3CYS187
3CYS230
3VAL232
3ALA234
3LEU235

site_idAC6
Number of Residues8
Detailsbinding site for residue SF4 3 803
ChainResidue
3CYS256
3CYS259
3GLY262
3CYS263
3ILE290
3CYS291
3PRO407
3ILE408

site_idAC7
Number of Residues10
Detailsbinding site for residue FES 3 804
ChainResidue
3LEU32
3PHE33
3CYS34
3SER35
3GLY43
3ALA44
3CYS45
3ARG46
3CYS48
3CYS83

site_idAC8
Number of Residues7
Detailsbinding site for residue SF4 6 201
ChainResidue
4ARG84
6CYS45
6CYS46
6ALA110
6CYS111
6CYS140
6PRO141

site_idAC9
Number of Residues9
Detailsbinding site for residue SF4 9 201
ChainResidue
9HIS41
9CYS63
9ILE68
9CYS98
9ILE99
9PHE100
9CYS101
9GLY102
9CYS104

site_idAD1
Number of Residues8
Detailsbinding site for residue SF4 9 202
ChainResidue
9CYS53
9ILE54
9GLY55
9CYS56
9SER57
9CYS59
9TYR91
9CYS108

Functional Information from PROSITE/UniProt
site_idPS00198
Number of Residues12
Details4FE4S_FER_1 4Fe-4S ferredoxin-type iron-sulfur binding region signature. CiGCSlCAaACP
ChainResidueDetails
9CYS53-PRO64
9CYS98-PRO109

site_idPS00535
Number of Residues12
DetailsCOMPLEX1_49K Respiratory chain NADH dehydrogenase 49 Kd subunit signature. LHTGfEKTmEhR
ChainResidueDetails
4LEU62-ARG73

site_idPS00542
Number of Residues22
DetailsCOMPLEX1_30K Respiratory chain NADH dehydrogenase 30 Kd subunit signature. EREvyDLFgivfegHpdlRkIL
ChainResidueDetails
5GLU115-LEU136

site_idPS00641
Number of Residues18
DetailsCOMPLEX1_75K_1 Respiratory-chain NADH dehydrogenase 75 Kd subunit signature 1. PlfCSekhlspiGaCRmC
ChainResidueDetails
3PRO31-CYS48

site_idPS00642
Number of Residues13
DetailsCOMPLEX1_75K_2 Respiratory-chain NADH dehydrogenase 75 Kd subunit signature 2. CPtCDkGGaCeLQ
ChainResidueDetails
3CYS119-GLN131

site_idPS00643
Number of Residues11
DetailsCOMPLEX1_75K_3 Respiratory-chain NADH dehydrogenase 75 Kd subunit signature 3. RCIhCkRCVrY
ChainResidueDetails
3ARG180-TYR190

site_idPS00644
Number of Residues16
DetailsCOMPLEX1_51K_1 Respiratory-chain NADH dehydrogenase 51 Kd subunit signature 1. GAGAYICGEETALMNS
ChainResidueDetails
1GLY176-SER191

site_idPS00645
Number of Residues12
DetailsCOMPLEX1_51K_2 Respiratory-chain NADH dehydrogenase 51 Kd subunit signature 2. ESCGkCtPCReG
ChainResidueDetails
1GLU351-GLY362

site_idPS00667
Number of Residues16
DetailsCOMPLEX1_ND1_1 Respiratory-chain NADH dehydrogenase subunit 1 signature 1. GLLQpLaDAIKSIfKE
ChainResidueDetails
HGLY55-GLU70

site_idPS00668
Number of Residues14
DetailsCOMPLEX1_ND1_2 Respiratory-chain NADH dehydrogenase subunit 1 signature 2. PFDLPEAEqeLVg.G
ChainResidueDetails
HPRO218-GLY231

site_idPS01099
Number of Residues19
DetailsCOMPLEX1_24K Respiratory-chain NADH dehydrogenase 24 Kd subunit signature. DglFSvqkveCLGsChtAP
ChainResidueDetails
2ASP114-PRO132

site_idPS01150
Number of Residues17
DetailsCOMPLEX1_20K Respiratory-chain NADH dehydrogenase 20 Kd subunit signature. NvDSVVPVDVYvPgCPP
ChainResidueDetails
6ASN126-PRO142

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues180
DetailsTRANSMEM: Helical => ECO:0000255
ChainResidueDetails
HTRP11-MET31
NLEU257-ASN277
NALA280-SER300
NLEU322-PHE342
NVAL360-LEU380
NALA400-LEU420
LGLY492-PHE512
LGLY584-MET604
HPHE80-ILE100
HLEU120-GLY140
HALA157-VAL177
HHIS192-ALA212
HPHE252-LEU272
HGLU273-ILE293
HTRP310-LEU330
HTYR336-PRO356

site_idSWS_FT_FI2
Number of Residues1
DetailsBINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU01184, ECO:0000269|PubMed:16469879
ChainResidueDetails
3HIS115
1ASN92
1TYR180
1ILE218
1CYS353
1CYS356
1CYS359
1CYS400

site_idSWS_FT_FI3
Number of Residues3
DetailsBINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU01184
ChainResidueDetails
3CYS119
3CYS122
3CYS128

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PDB entries from 2024-07-24

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