6ZJI

Cryo-EM structure of wild-type KatG from M. tuberculosis

This is a non-PDB format compatible entry.

Functional Information from GO Data

Chain	GOid	namespace	contents
AP1	0004096	molecular_function	catalase activity
AP1	0004601	molecular_function	peroxidase activity
AP1	0005515	molecular_function	protein binding
AP1	0005576	cellular_component	extracellular region
AP1	0005829	cellular_component	cytosol
AP1	0005886	cellular_component	plasma membrane
AP1	0006979	biological_process	response to oxidative stress
AP1	0009274	cellular_component	peptidoglycan-based cell wall
AP1	0016491	molecular_function	oxidoreductase activity
AP1	0016677	molecular_function	oxidoreductase activity, acting on a heme group of donors, nitrogenous group as acceptor
AP1	0020037	molecular_function	heme binding
AP1	0042744	biological_process	hydrogen peroxide catabolic process
AP1	0045739	biological_process	positive regulation of DNA repair
AP1	0046677	biological_process	response to antibiotic
AP1	0046872	molecular_function	metal ion binding
AP1	0070301	biological_process	cellular response to hydrogen peroxide
AP1	0070402	molecular_function	NADPH binding
AP1	0070404	molecular_function	NADH binding
AP1	0098869	biological_process	cellular oxidant detoxification
BP1	0004096	molecular_function	catalase activity
BP1	0004601	molecular_function	peroxidase activity
BP1	0005515	molecular_function	protein binding
BP1	0005576	cellular_component	extracellular region
BP1	0005829	cellular_component	cytosol
BP1	0005886	cellular_component	plasma membrane
BP1	0006979	biological_process	response to oxidative stress
BP1	0009274	cellular_component	peptidoglycan-based cell wall
BP1	0016491	molecular_function	oxidoreductase activity
BP1	0016677	molecular_function	oxidoreductase activity, acting on a heme group of donors, nitrogenous group as acceptor
BP1	0020037	molecular_function	heme binding
BP1	0042744	biological_process	hydrogen peroxide catabolic process
BP1	0045739	biological_process	positive regulation of DNA repair
BP1	0046677	biological_process	response to antibiotic
BP1	0046872	molecular_function	metal ion binding
BP1	0070301	biological_process	cellular response to hydrogen peroxide
BP1	0070402	molecular_function	NADPH binding
BP1	0070404	molecular_function	NADH binding
BP1	0098869	biological_process	cellular oxidant detoxification

Functional Information from PROSITE/UniProt

site_id	PS00435
Number of Residues	11
Details	PEROXIDASE_1 Peroxidases proximal heme-ligand signature. TAALIVGGHTF

Chain	Residue	Details
AP1	THR262-PHE272

---

site_id	PS00436
Number of Residues	12
Details	PEROXIDASE_2 Peroxidases active site signature. GPlfIRMaWHAA

Chain	Residue	Details
AP1	GLY99-ALA110

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	Active site: {"description":"Proton acceptor","evidences":[{"source":"HAMAP-Rule","id":"MF_01961","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	2
Details	Binding site: {"description":"axial binding residue","evidences":[{"source":"PubMed","id":"15231843","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16566587","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"24185282","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1SJ2","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2CCA","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2CCD","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4C51","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	2
Details	Site: {"description":"Transition state stabilizer","evidences":[{"source":"HAMAP-Rule","id":"MF_01961","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	4
Details	Cross-link: {"description":"Tryptophyl-tyrosyl-methioninium (Tyr-Met) (with W-107); alternate","evidences":[{"source":"HAMAP-Rule","id":"MF_01961","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"15231843","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	2
Details	Active site: {"description":"Tryptophan radical intermediate","evidences":[{"source":"PubMed","id":"18052167","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

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