6ZJE
Crystal structure of human adenylate kinase 3, AK3, in complex with inhibitor Ap5A
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0004017 | molecular_function | adenylate kinase activity |
A | 0005515 | molecular_function | protein binding |
A | 0005524 | molecular_function | ATP binding |
A | 0005525 | molecular_function | GTP binding |
A | 0005737 | cellular_component | cytoplasm |
A | 0005739 | cellular_component | mitochondrion |
A | 0005759 | cellular_component | mitochondrial matrix |
A | 0006139 | biological_process | nucleobase-containing compound metabolic process |
A | 0006172 | biological_process | ADP biosynthetic process |
A | 0007596 | biological_process | blood coagulation |
A | 0009117 | biological_process | nucleotide metabolic process |
A | 0009123 | biological_process | nucleoside monophosphate metabolic process |
A | 0009142 | biological_process | nucleoside triphosphate biosynthetic process |
A | 0016301 | molecular_function | kinase activity |
A | 0016310 | biological_process | phosphorylation |
A | 0016776 | molecular_function | phosphotransferase activity, phosphate group as acceptor |
A | 0016874 | molecular_function | ligase activity |
A | 0019205 | molecular_function | nucleobase-containing compound kinase activity |
A | 0043231 | cellular_component | intracellular membrane-bounded organelle |
A | 0046033 | biological_process | AMP metabolic process |
A | 0046039 | biological_process | GTP metabolic process |
A | 0046041 | biological_process | ITP metabolic process |
A | 0046051 | biological_process | UTP metabolic process |
A | 0046899 | molecular_function | nucleoside triphosphate adenylate kinase activity |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 40 |
Details | binding site for residue AP5 A 401 |
Chain | Residue |
A | PRO16 |
A | LEU65 |
A | ILE66 |
A | MET71 |
A | GLY91 |
A | ARG94 |
A | GLN98 |
A | ARG124 |
A | LEU125 |
A | ARG172 |
A | THR201 |
A | GLY17 |
A | CL402 |
A | MG405 |
A | HOH501 |
A | HOH503 |
A | HOH504 |
A | HOH511 |
A | HOH512 |
A | HOH541 |
A | HOH545 |
A | HOH553 |
A | GLY21 |
A | HOH575 |
A | HOH613 |
A | HOH663 |
A | HOH665 |
A | HOH692 |
A | HOH694 |
A | HOH717 |
A | HOH725 |
A | HOH733 |
A | HOH748 |
A | SER38 |
A | HOH766 |
A | GLY39 |
A | LEU42 |
A | ARG43 |
A | ILE60 |
A | LYS64 |
site_id | AC2 |
Number of Residues | 6 |
Details | binding site for residue CL A 402 |
Chain | Residue |
A | GLY17 |
A | SER18 |
A | GLY19 |
A | LYS20 |
A | GLY21 |
A | AP5401 |
site_id | AC3 |
Number of Residues | 2 |
Details | binding site for residue CL A 403 |
Chain | Residue |
A | ARG128 |
A | ASN139 |
site_id | AC4 |
Number of Residues | 4 |
Details | binding site for residue NA A 404 |
Chain | Residue |
A | ASN143 |
A | HOH547 |
A | HOH552 |
A | HOH643 |
site_id | AC5 |
Number of Residues | 7 |
Details | binding site for residue MG A 405 |
Chain | Residue |
A | AP5401 |
A | HOH541 |
A | HOH545 |
A | HOH607 |
A | HOH631 |
A | HOH665 |
A | HOH731 |
Functional Information from PROSITE/UniProt
site_id | PS00113 |
Number of Residues | 12 |
Details | ADENYLATE_KINASE Adenylate kinase signature. WLLDGFPRtlpQ |
Chain | Residue | Details |
A | TRP87-GLN98 |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 11 |
Details | BINDING: BINDING => ECO:0000255|HAMAP-Rule:MF_03169 |
Chain | Residue | Details |
A | GLY17 | |
A | ARG172 | |
A | THR201 | |
A | SER38 | |
A | ARG43 | |
A | LYS64 | |
A | GLY91 | |
A | GLN98 | |
A | ARG128 | |
A | VAL137 | |
A | ARG161 |
site_id | SWS_FT_FI2 |
Number of Residues | 2 |
Details | MOD_RES: N6-succinyllysine => ECO:0000250|UniProtKB:Q9WTP7 |
Chain | Residue | Details |
A | LYS20 | |
A | LYS57 |
site_id | SWS_FT_FI3 |
Number of Residues | 2 |
Details | MOD_RES: N6-acetyllysine => ECO:0000250|UniProtKB:Q9WTP7 |
Chain | Residue | Details |
A | LYS34 | |
A | LYS203 |
site_id | SWS_FT_FI4 |
Number of Residues | 1 |
Details | MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:Q9WTP7 |
Chain | Residue | Details |
A | SER37 |
site_id | SWS_FT_FI5 |
Number of Residues | 4 |
Details | MOD_RES: N6-succinyllysine; alternate => ECO:0000250|UniProtKB:Q9WTP7 |
Chain | Residue | Details |
A | LYS64 | |
A | LYS80 | |
A | LYS174 | |
A | LYS189 |