6ZIO
CRYSTAL STRUCTURE OF NRAS (C118S) IN COMPLEX WITH GDP
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000139 | cellular_component | Golgi membrane |
| A | 0000165 | biological_process | MAPK cascade |
| A | 0000166 | molecular_function | nucleotide binding |
| A | 0001938 | biological_process | positive regulation of endothelial cell proliferation |
| A | 0003924 | molecular_function | GTPase activity |
| A | 0003925 | molecular_function | G protein activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0005525 | molecular_function | GTP binding |
| A | 0005789 | cellular_component | endoplasmic reticulum membrane |
| A | 0005794 | cellular_component | Golgi apparatus |
| A | 0005829 | cellular_component | cytosol |
| A | 0005886 | cellular_component | plasma membrane |
| A | 0007165 | biological_process | signal transduction |
| A | 0007265 | biological_process | Ras protein signal transduction |
| A | 0008284 | biological_process | positive regulation of cell population proliferation |
| A | 0016020 | cellular_component | membrane |
| A | 0016787 | molecular_function | hydrolase activity |
| A | 0044877 | molecular_function | protein-containing complex binding |
| A | 0046579 | biological_process | positive regulation of Ras protein signal transduction |
| A | 0070062 | cellular_component | extracellular exosome |
| A | 0070821 | cellular_component | tertiary granule membrane |
| B | 0000139 | cellular_component | Golgi membrane |
| B | 0000165 | biological_process | MAPK cascade |
| B | 0000166 | molecular_function | nucleotide binding |
| B | 0001938 | biological_process | positive regulation of endothelial cell proliferation |
| B | 0003924 | molecular_function | GTPase activity |
| B | 0003925 | molecular_function | G protein activity |
| B | 0005515 | molecular_function | protein binding |
| B | 0005525 | molecular_function | GTP binding |
| B | 0005789 | cellular_component | endoplasmic reticulum membrane |
| B | 0005794 | cellular_component | Golgi apparatus |
| B | 0005829 | cellular_component | cytosol |
| B | 0005886 | cellular_component | plasma membrane |
| B | 0007165 | biological_process | signal transduction |
| B | 0007265 | biological_process | Ras protein signal transduction |
| B | 0008284 | biological_process | positive regulation of cell population proliferation |
| B | 0016020 | cellular_component | membrane |
| B | 0016787 | molecular_function | hydrolase activity |
| B | 0044877 | molecular_function | protein-containing complex binding |
| B | 0046579 | biological_process | positive regulation of Ras protein signal transduction |
| B | 0070062 | cellular_component | extracellular exosome |
| B | 0070821 | cellular_component | tertiary granule membrane |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 6 |
| Details | binding site for residue MG A 201 |
| Chain | Residue |
| A | SER17 |
| A | GDP202 |
| A | HOH302 |
| A | HOH305 |
| A | HOH309 |
| A | HOH369 |
| site_id | AC2 |
| Number of Residues | 24 |
| Details | binding site for residue GDP A 202 |
| Chain | Residue |
| A | LYS16 |
| A | SER17 |
| A | ALA18 |
| A | PHE28 |
| A | VAL29 |
| A | ASP30 |
| A | ASN116 |
| A | LYS117 |
| A | ASP119 |
| A | LEU120 |
| A | SER145 |
| A | ALA146 |
| A | LYS147 |
| A | MG201 |
| A | HOH302 |
| A | HOH327 |
| A | HOH339 |
| A | HOH352 |
| A | HOH369 |
| A | HOH373 |
| A | HOH401 |
| A | GLY13 |
| A | VAL14 |
| A | GLY15 |
| site_id | AC3 |
| Number of Residues | 6 |
| Details | binding site for residue MG B 201 |
| Chain | Residue |
| B | SER17 |
| B | GDP203 |
| B | HOH301 |
| B | HOH312 |
| B | HOH314 |
| B | HOH315 |
| site_id | AC4 |
| Number of Residues | 5 |
| Details | binding site for residue MG B 202 |
| Chain | Residue |
| B | ALA18 |
| B | GLN22 |
| B | HIS27 |
| B | PHE28 |
| B | VAL29 |
| site_id | AC5 |
| Number of Residues | 24 |
| Details | binding site for residue GDP B 203 |
| Chain | Residue |
| B | GLY13 |
| B | VAL14 |
| B | GLY15 |
| B | LYS16 |
| B | SER17 |
| B | ALA18 |
| B | PHE28 |
| B | VAL29 |
| B | ASP30 |
| B | ASN116 |
| B | LYS117 |
| B | ASP119 |
| B | LEU120 |
| B | SER145 |
| B | ALA146 |
| B | LYS147 |
| B | MG201 |
| B | HOH301 |
| B | HOH314 |
| B | HOH338 |
| B | HOH359 |
| B | HOH364 |
| B | HOH370 |
| B | HOH375 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 16 |
| Details | Motif: {"description":"Effector region"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 24 |
| Details | Binding site: {"evidences":[{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"MAR-2008","submissionDatabase":"PDB data bank","title":"Crystal structure of the human NRAS GTPase bound with GDP.","authors":["Nedyalkova L.","Tong Y.","Tempel W.","Shen L.","Loppnau P.","Arrowsmith C.H.","Edwards A.M.","Bountra C.","Weigelt J.","Bochkarev A.","Park H."]}}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 8 |
| Details | Binding site: {"evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"30712867","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 2 |
| Details | Glycosylation: {"description":"(Microbial infection) O-linked (Glc) threonine; by P.sordellii toxin TcsL","evidences":[{"source":"PubMed","id":"19744486","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 2 |
| Details | Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)","evidences":[{"source":"PubMed","id":"30442762","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
