Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

6ZHV

Crystal structure of OmpF porin soaked in ciprofloxacin metaloantibiotic

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0009279	cellular_component	cell outer membrane
A	0015288	molecular_function	porin activity
A	0016020	cellular_component	membrane
A	0034220	biological_process	monoatomic ion transmembrane transport
B	0009279	cellular_component	cell outer membrane
B	0015288	molecular_function	porin activity
B	0016020	cellular_component	membrane
B	0034220	biological_process	monoatomic ion transmembrane transport
C	0009279	cellular_component	cell outer membrane
C	0015288	molecular_function	porin activity
C	0016020	cellular_component	membrane
C	0034220	biological_process	monoatomic ion transmembrane transport

Functional Information from PDB Data

site_id	AC1
Number of Residues	6
Details	binding site for residue MG B 401

Chain	Residue
B	ASN229
B	ASN258
B	ASN274
B	HOH539
B	HOH546
B	HOH552

site_id	AC2
Number of Residues	5
Details	binding site for residue NA B 402

Chain	Residue
B	ALA97
B	HOH532
A	LYS102
A	THR103
A	HOH539

site_id	AC3
Number of Residues	5
Details	binding site for residue NA B 403

Chain	Residue
A	TYR85
A	HOH541
B	TYR85
B	HOH544
C	HOH536

site_id	AC4
Number of Residues	4
Details	binding site for residue NA B 404

Chain	Residue
B	ASN338
B	ILE340
B	SER350
B	HOH550

site_id	AC5
Number of Residues	4
Details	binding site for residue NA B 405

Chain	Residue
B	GLU223
B	GLN225
B	GLY228
B	HOH553

site_id	AC6
Number of Residues	4
Details	binding site for residue NA B 406

Chain	Residue
B	ARG218
B	GLN222
B	LEU227
B	GLY228

site_id	AC7
Number of Residues	6
Details	binding site for residue QLB B 407

Chain	Residue
A	TYR120
A	TYR179
A	LEU180
B	THR331
B	VAL333
B	VAL356

site_id	AC8
Number of Residues	4
Details	binding site for residue MG A 401

Chain	Residue
A	ASN229
A	ASN258
A	ASN274
A	HOH542

site_id	AC9
Number of Residues	3
Details	binding site for residue NA A 402

Chain	Residue
A	GLU223
A	GLN225
A	GLY228

site_id	AD1
Number of Residues	3
Details	binding site for residue NA A 403

Chain	Residue
A	ASP312
A	ASP341
A	HOH550

site_id	AD2
Number of Residues	4
Details	binding site for residue NA A 404

Chain	Residue
A	MET329
A	SER330
A	GLN361
A	HOH538

site_id	AD3
Number of Residues	5
Details	binding site for residue NA A 405

Chain	Residue
A	ARG218
A	GLN222
A	LEU227
A	GLY228
A	PHE272

site_id	AD4
Number of Residues	4
Details	binding site for residue QLB A 406

Chain	Residue
A	THR331
A	VAL333
A	VAL356
C	PHE118

site_id	AD5
Number of Residues	8
Details	binding site for residue QLB A 407

Chain	Residue
A	LEU249
A	ALA250
A	LEU281
A	VAL282
A	ALA283
A	PHE317
A	VAL319
B	VAL279

site_id	AD6
Number of Residues	6
Details	binding site for residue MG C 401

Chain	Residue
C	ASN229
C	ASN258
C	ASN274
C	HOH549
C	HOH550
C	HOH559

site_id	AD7
Number of Residues	3
Details	binding site for residue NA C 402

Chain	Residue
C	GLU223
C	GLN225
C	GLY228

site_id	AD8
Number of Residues	3
Details	binding site for residue NA C 403

Chain	Residue
C	HOH503
C	HOH551
C	HOH552

site_id	AD9
Number of Residues	5
Details	binding site for residue NA C 404

Chain	Residue
C	ARG218
C	GLN222
C	LEU227
C	GLY228
C	PHE272

site_id	AE1
Number of Residues	8
Details	binding site for residue QLB C 405

Chain	Residue
C	PHE166
C	ALA176
C	VAL177
C	GLY198
C	SER199
C	GLY211
C	ALA212
C	PHE287

site_id	AE2
Number of Residues	6
Details	binding site for residue QLB C 406

Chain	Residue
C	VAL196
C	TYR213
C	ALA215
C	LYS232
C	TYR285
C	PHE287

site_id	AE3
Number of Residues	6
Details	binding site for residue QLB C 407

Chain	Residue
B	GLY195
B	VAL196
C	VAL356
B	TYR179
B	LEU180
B	GLY181

site_id	AE4
Number of Residues	3
Details	binding site for residue QLB C 408

Chain	Residue
C	ALA250
C	LEU281
C	ILE295

Functional Information from PROSITE/UniProt

site_id	PS00576
Number of Residues	17
Details	GRAM_NEG_PORIN General diffusion Gram-negative porins signature. FevGatYyFnKnmSTYV

Chain	Residue	Details
B	PHE317-VAL333

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	510
Details	TRANSMEM: Beta stranded

Chain	Residue	Details
B	ALA23-LYS28
B	GLY206-ASP217
B	ALA233-ALA244
B	ASN246-ARG257
B	LYS275-PHE287
B	GLY290-LYS303
B	VAL314-PHE325
B	ASN328-ILE337
B	THR353-PHE362
A	ALA23-LYS28
A	GLY30-PHE45
B	GLY30-PHE45
A	THR61-ILE73
A	ASP76-GLN88
A	LEU105-ALA113
A	GLY116-ARG122
A	GLY157-ASN163
A	GLY172-GLY181
A	ASP194-TYR204
A	GLY206-ASP217
A	ALA233-ALA244
A	ASN246-ARG257
B	THR61-ILE73
A	LYS275-PHE287
A	GLY290-LYS303
A	VAL314-PHE325
A	ASN328-ILE337
A	THR353-PHE362
C	ALA23-LYS28
C	GLY30-PHE45
C	THR61-ILE73
C	ASP76-GLN88
C	LEU105-ALA113
B	ASP76-GLN88
C	GLY116-ARG122
C	GLY157-ASN163
C	GLY172-GLY181
C	ASP194-TYR204
C	GLY206-ASP217
C	ALA233-ALA244
C	ASN246-ARG257
C	LYS275-PHE287
C	GLY290-LYS303
C	VAL314-PHE325
B	LEU105-ALA113
C	ASN328-ILE337
C	THR353-PHE362
B	GLY116-ARG122
B	GLY157-ASN163
B	GLY172-GLY181
B	ASP194-TYR204

site_id	SWS_FT_FI2
Number of Residues	42
Details	TOPO_DOM: Periplasmic

Chain	Residue	Details
B	ASP29
A	ASN74-SER75
A	ASP114-VAL115
A	SER164-ASP171
A	GLU205
A	ASN245
A	ASP288-PHE289
A	ASN326-LYS327
C	ASP29
C	ASN74-SER75
C	ASP114-VAL115
B	ASN74-SER75
C	SER164-ASP171
C	GLU205
C	ASN245
C	ASP288-PHE289
C	ASN326-LYS327
B	ASP114-VAL115
B	SER164-ASP171
B	GLU205
B	ASN245
B	ASP288-PHE289
B	ASN326-LYS327
A	ASP29

site_id	SWS_FT_FI3
Number of Residues	378
Details	TOPO_DOM: Extracellular

Chain	Residue	Details
B	SER46-MET60
A	GLY89-ARG104
A	ASN123-GLY156
A	LYS182-GLY193
A	ARG218-LYS232
A	ASN258-ASN274
A	ASP304-LEU313
A	ASN338-ASP352
C	SER46-MET60
C	GLY89-ARG104
C	ASN123-GLY156
B	GLY89-ARG104
C	LYS182-GLY193
C	ARG218-LYS232
C	ASN258-ASN274
C	ASP304-LEU313
C	ASN338-ASP352
B	ASN123-GLY156
B	LYS182-GLY193
B	ARG218-LYS232
B	ASN258-ASN274
B	ASP304-LEU313
B	ASN338-ASP352
A	SER46-MET60

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)