6ZHT

Uba1-Ubc13 disulfide mediated complex

Functional Information from GO Data

Chain	GOid	namespace	contents
B	0000166	molecular_function	nucleotide binding
B	0000209	biological_process	protein polyubiquitination
B	0000329	cellular_component	fungal-type vacuole membrane
B	0004842	molecular_function	ubiquitin-protein transferase activity
B	0005515	molecular_function	protein binding
B	0005524	molecular_function	ATP binding
B	0005634	cellular_component	nucleus
B	0005737	cellular_component	cytoplasm
B	0005829	cellular_component	cytosol
B	0006301	biological_process	postreplication repair
B	0010994	biological_process	free ubiquitin chain polymerization
B	0016567	biological_process	protein ubiquitination
B	0016740	molecular_function	transferase activity
B	0031371	cellular_component	ubiquitin conjugating enzyme complex
B	0044395	biological_process	protein targeting to vacuolar membrane
B	0061631	molecular_function	ubiquitin conjugating enzyme activity
B	0070534	biological_process	protein K63-linked ubiquitination
C	0000166	molecular_function	nucleotide binding
C	0004839	molecular_function	ubiquitin activating enzyme activity
C	0005515	molecular_function	protein binding
C	0005524	molecular_function	ATP binding
C	0005634	cellular_component	nucleus
C	0005737	cellular_component	cytoplasm
C	0006511	biological_process	ubiquitin-dependent protein catabolic process
C	0006974	biological_process	DNA damage response
C	0008641	molecular_function	ubiquitin-like modifier activating enzyme activity
C	0016567	biological_process	protein ubiquitination
C	0016874	molecular_function	ligase activity
C	0036211	biological_process	protein modification process
C	0046872	molecular_function	metal ion binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	7
Details	binding site for residue GOL C 1101

Chain	Residue
C	SER153
C	GLU155
C	ASN162
C	PHE296
C	GLN297
C	HOH1204
C	HOH1213

---

site_id	AC2
Number of Residues	3
Details	binding site for residue GOL C 1102

Chain	Residue
C	HOH1230
C	GLU525
C	TYR959

---

site_id	AC3
Number of Residues	5
Details	binding site for residue GOL C 1103

Chain	Residue
C	GLU534
C	PHE558
C	TYR559
C	ARG930
C	HOH1282

---

site_id	AC4
Number of Residues	2
Details	binding site for residue GOL C 1104

Chain	Residue
C	ASN900
C	LEU903

---

site_id	AC5
Number of Residues	5
Details	binding site for residue GOL C 1105

Chain	Residue
C	ARG554
C	VAL557
C	ILE1002
C	GLU1004
C	PHE1019

---

site_id	AC6
Number of Residues	5
Details	binding site for residue GOL C 1106

Chain	Residue
C	LYS45
C	GLU69
C	ARG91
C	THR131
C	HOH1284

---

site_id	AC7
Number of Residues	3
Details	binding site for residue GOL C 1107

Chain	Residue
C	LYS430
C	GLY461
C	SER462

---

site_id	AC8
Number of Residues	5
Details	binding site for residue GOL C 1109

Chain	Residue
C	ALA614
C	LYS617
C	SER618
C	GLN621
C	HOH1272

---

site_id	AC9
Number of Residues	4
Details	binding site for residue GOL C 1110

Chain	Residue
C	ASP932
C	LYS934
C	LYS934
C	HIS1023

---

site_id	AD1
Number of Residues	8
Details	binding site for residue GOL C 1111

Chain	Residue
C	ASP470
C	ASN471
C	ASP518
C	LYS519
C	VAL520
C	LEU543
C	ALA548
C	HOH1412

---

site_id	AD2
Number of Residues	4
Details	binding site for residue CL C 1112

Chain	Residue
C	GLN372
C	LEU375
C	SER379
C	PHE382

---

site_id	AD3
Number of Residues	2
Details	binding site for residue CL C 1113

Chain	Residue
C	LYS229
C	LYS229

---

site_id	AD4
Number of Residues	7
Details	binding site for residue GOL B 201

Chain	Residue
B	ILE86
B	CYS87
B	LEU88
B	LEU91
B	LYS92
C	PRO598
C	LEU599

---

Functional Information from PROSITE/UniProt

site_id	PS00183
Number of Residues	16
Details	UBC_1 Ubiquitin-conjugating (UBC) active site signature. YHPNIdrl.GrICLdvL

Chain	Residue	Details
B	TYR76-LEU91

---

site_id	PS00536
Number of Residues	9
Details	UBIQUITIN_ACTIVAT_1 Ubiquitin-activating enzyme signature 1. KACSGKFtP

Chain	Residue	Details
C	LYS376-PRO384

---

site_id	PS00865
Number of Residues	9
Details	UBIQUITIN_ACTIVAT_2 Ubiquitin-activating enzyme active site. PLCTLRsFP

Chain	Residue	Details
C	PRO598-PRO606

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	137
Details	Repeat: {"description":"1-1"}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	154
Details	Repeat: {"description":"1-2"}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	552
Details	Region: {"description":"2 approximate repeats"}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	1
Details	Active site: {"description":"Glycyl thioester intermediate","evidences":[{"source":"PROSITE-ProRule","id":"PRU10132","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"24816100","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	5
Details	Binding site: {"evidences":[{"source":"PubMed","id":"35970836","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"24816100","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"7ZH9","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	6
Details	Binding site: {"evidences":[{"source":"PubMed","id":"35970836","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7ZH9","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	1
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"17287358","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	1
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"18407956","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI9
Number of Residues	5
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)","evidences":[{"source":"PubMed","id":"22106047","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI10
Number of Residues	146
Details	Domain: {"description":"UBC core","evidences":[{"source":"PROSITE-ProRule","id":"PRU00388","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI11
Number of Residues	1
Details	Active site: {"description":"Glycyl thioester intermediate","evidences":[{"source":"PROSITE-ProRule","id":"PRU00388","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

Catalytic Information from CSA

site_id	MCSA1
Number of Residues	5
Details	M-CSA 307

Chain

Residue

Details

---

site_id	MCSA2
Number of Residues	3
Details	M-CSA 939

Chain

Residue

Details

---