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6ZGY

Structure of human galactokinase 1 bound with 2-(4-chlorophenyl)-N-(pyrimidin-2-yl)acetamide

Functional Information from GO Data
ChainGOidnamespacecontents
A0004335molecular_functiongalactokinase activity
A0005515molecular_functionprotein binding
A0005524molecular_functionATP binding
A0005534molecular_functiongalactose binding
A0005737cellular_componentcytoplasm
A0005829cellular_componentcytosol
A0006012biological_processgalactose metabolic process
A0016020cellular_componentmembrane
A0016301molecular_functionkinase activity
A0016773molecular_functionphosphotransferase activity, alcohol group as acceptor
A0019402biological_processgalactitol metabolic process
A0033499biological_processgalactose catabolic process via UDP-galactose
A0046835biological_processcarbohydrate phosphorylation
A0061623biological_processglycolytic process from galactose
A0070062cellular_componentextracellular exosome
B0004335molecular_functiongalactokinase activity
B0005515molecular_functionprotein binding
B0005524molecular_functionATP binding
B0005534molecular_functiongalactose binding
B0005737cellular_componentcytoplasm
B0005829cellular_componentcytosol
B0006012biological_processgalactose metabolic process
B0016020cellular_componentmembrane
B0016301molecular_functionkinase activity
B0016773molecular_functionphosphotransferase activity, alcohol group as acceptor
B0019402biological_processgalactitol metabolic process
B0033499biological_processgalactose catabolic process via UDP-galactose
B0046835biological_processcarbohydrate phosphorylation
B0061623biological_processglycolytic process from galactose
B0070062cellular_componentextracellular exosome
D0004335molecular_functiongalactokinase activity
D0005515molecular_functionprotein binding
D0005524molecular_functionATP binding
D0005534molecular_functiongalactose binding
D0005737cellular_componentcytoplasm
D0005829cellular_componentcytosol
D0006012biological_processgalactose metabolic process
D0016020cellular_componentmembrane
D0016301molecular_functionkinase activity
D0016773molecular_functionphosphotransferase activity, alcohol group as acceptor
D0019402biological_processgalactitol metabolic process
D0033499biological_processgalactose catabolic process via UDP-galactose
D0046835biological_processcarbohydrate phosphorylation
D0061623biological_processglycolytic process from galactose
D0070062cellular_componentextracellular exosome
E0004335molecular_functiongalactokinase activity
E0005515molecular_functionprotein binding
E0005524molecular_functionATP binding
E0005534molecular_functiongalactose binding
E0005737cellular_componentcytoplasm
E0005829cellular_componentcytosol
E0006012biological_processgalactose metabolic process
E0016020cellular_componentmembrane
E0016301molecular_functionkinase activity
E0016773molecular_functionphosphotransferase activity, alcohol group as acceptor
E0019402biological_processgalactitol metabolic process
E0033499biological_processgalactose catabolic process via UDP-galactose
E0046835biological_processcarbohydrate phosphorylation
E0061623biological_processglycolytic process from galactose
E0070062cellular_componentextracellular exosome
Functional Information from PROSITE/UniProt
site_idPS00106
Number of Residues12
DetailsGALACTOKINASE Galactokinase signature. GRvNLIGEHtDY
ChainResidueDetails
AGLY36-TYR47

site_idPS00627
Number of Residues12
DetailsGHMP_KINASES_ATP GHMP kinases putative ATP-binding domain. VPlGgGLSSSAS
ChainResidueDetails
AVAL133-SER144

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues4
DetailsACT_SITE: Proton acceptor => ECO:0000250|UniProtKB:Q9HHB6
ChainResidueDetails
AASP186
BASP186
EASP186
DASP186

site_idSWS_FT_FI2
Number of Residues40
DetailsBINDING: BINDING => ECO:0000250|UniProtKB:P04385
ChainResidueDetails
BSER140
BSER141
BASP186
BTYR236
EARG37
EGLU43
EHIS44
EASP46
EGLY136
EGLY138
ESER140
ESER141
EASP186
ETYR236
DARG37
DGLU43
DHIS44
DASP46
DGLY136
DGLY138
DSER140
DSER141
DASP186
DTYR236
AGLU43
AHIS44
AASP46
AGLY136
AGLY138
ASER140
ASER141
AASP186
ATYR236
BARG37
BGLU43
BHIS44
BASP46
BGLY136
BGLY138
AARG37

site_idSWS_FT_FI3
Number of Residues4
DetailsSITE: Transition state stabilizer => ECO:0000250|UniProtKB:Q9HHB6
ChainResidueDetails
BARG37
EARG37
DARG37
AARG37

site_idSWS_FT_FI4
Number of Residues4
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:24275569
ChainResidueDetails
BSER230
ESER230
DSER230
ASER230

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PDB entries from 2024-06-12

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