6ZGM

Crystal Structure of the VIM-2 Acquired Metallo-beta-Lactamase in Complex with the thiazolecarboxylate inhibitor ANT2681

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0016787	molecular_function	hydrolase activity
A	0017001	biological_process	antibiotic catabolic process
A	0042597	cellular_component	periplasmic space
A	0046677	biological_process	response to antibiotic
A	0046872	molecular_function	metal ion binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	binding site for residue ZN A 401

Chain	Residue
A	HIS116
A	HIS118
A	HIS196
A	HOH535

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site_id	AC2
Number of Residues	5
Details	binding site for residue ZN A 402

Chain	Residue
A	ASP120
A	CYS221
A	HIS263
A	QKK406
A	HOH535

---

site_id	AC3
Number of Residues	4
Details	binding site for residue ZN A 403

Chain	Residue
A	HIS170
A	HIS285
A	ACT404
A	ACT405

---

site_id	AC4
Number of Residues	8
Details	binding site for residue ACT A 404

Chain	Residue
A	ALA135
A	HIS170
A	HIS285
A	ASN288
A	ZN403
A	ACT405
A	HOH508
A	HOH661

---

site_id	AC5
Number of Residues	8
Details	binding site for residue ACT A 405

Chain	Residue
A	ARG129
A	ALA135
A	THR169
A	HIS170
A	HIS285
A	ZN403
A	ACT404
A	HOH543

---

site_id	AC6
Number of Residues	14
Details	binding site for residue QKK A 406

Chain	Residue
A	PHE61
A	ASP120
A	HIS196
A	CYS221
A	ARG228
A	GLY232
A	ASN233
A	VAL234
A	ALA235
A	HIS263
A	ZN402
A	HOH535
A	HOH548
A	HOH578

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