6ZG1
SARM1 SAM1-2 domains
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003953 | molecular_function | NAD+ nucleosidase activity |
| A | 0034128 | biological_process | negative regulation of MyD88-independent toll-like receptor signaling pathway |
| A | 0035591 | molecular_function | signaling adaptor activity |
| A | 0048678 | biological_process | response to axon injury |
| B | 0003953 | molecular_function | NAD+ nucleosidase activity |
| B | 0034128 | biological_process | negative regulation of MyD88-independent toll-like receptor signaling pathway |
| B | 0035591 | molecular_function | signaling adaptor activity |
| B | 0048678 | biological_process | response to axon injury |
| C | 0003953 | molecular_function | NAD+ nucleosidase activity |
| C | 0034128 | biological_process | negative regulation of MyD88-independent toll-like receptor signaling pathway |
| C | 0035591 | molecular_function | signaling adaptor activity |
| C | 0048678 | biological_process | response to axon injury |
| D | 0003953 | molecular_function | NAD+ nucleosidase activity |
| D | 0034128 | biological_process | negative regulation of MyD88-independent toll-like receptor signaling pathway |
| D | 0035591 | molecular_function | signaling adaptor activity |
| D | 0048678 | biological_process | response to axon injury |
| E | 0003953 | molecular_function | NAD+ nucleosidase activity |
| E | 0034128 | biological_process | negative regulation of MyD88-independent toll-like receptor signaling pathway |
| E | 0035591 | molecular_function | signaling adaptor activity |
| E | 0048678 | biological_process | response to axon injury |
| F | 0003953 | molecular_function | NAD+ nucleosidase activity |
| F | 0034128 | biological_process | negative regulation of MyD88-independent toll-like receptor signaling pathway |
| F | 0035591 | molecular_function | signaling adaptor activity |
| F | 0048678 | biological_process | response to axon injury |
| G | 0003953 | molecular_function | NAD+ nucleosidase activity |
| G | 0034128 | biological_process | negative regulation of MyD88-independent toll-like receptor signaling pathway |
| G | 0035591 | molecular_function | signaling adaptor activity |
| G | 0048678 | biological_process | response to axon injury |
| H | 0003953 | molecular_function | NAD+ nucleosidase activity |
| H | 0034128 | biological_process | negative regulation of MyD88-independent toll-like receptor signaling pathway |
| H | 0035591 | molecular_function | signaling adaptor activity |
| H | 0048678 | biological_process | response to axon injury |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 3 |
| Details | binding site for residue EDO A 601 |
| Chain | Residue |
| A | LYS428 |
| A | SER432 |
| A | LEU455 |
| site_id | AC2 |
| Number of Residues | 2 |
| Details | binding site for residue BME A 602 |
| Chain | Residue |
| A | CYS482 |
| A | TYR503 |
| site_id | AC3 |
| Number of Residues | 4 |
| Details | binding site for residue EDO A 603 |
| Chain | Residue |
| A | GLY425 |
| A | LYS428 |
| A | ARG465 |
| B | GLN437 |
| site_id | AC4 |
| Number of Residues | 2 |
| Details | binding site for residue EDO B 601 |
| Chain | Residue |
| B | LEU444 |
| B | GLY504 |
| site_id | AC5 |
| Number of Residues | 8 |
| Details | binding site for residue EDO B 602 |
| Chain | Residue |
| B | ALA477 |
| B | ASN478 |
| B | TYR479 |
| B | SER480 |
| B | ASP483 |
| B | ASN486 |
| B | ALA488 |
| B | ARG499 |
| site_id | AC6 |
| Number of Residues | 4 |
| Details | binding site for residue PEG B 603 |
| Chain | Residue |
| B | ARG497 |
| B | GLN500 |
| B | HIS534 |
| C | SER507 |
| site_id | AC7 |
| Number of Residues | 9 |
| Details | binding site for residue PGE B 605 |
| Chain | Residue |
| B | PRO402 |
| B | ARG403 |
| B | PRO404 |
| B | TRP412 |
| B | GLU416 |
| B | TRP420 |
| B | GLN423 |
| B | GLU472 |
| B | LEU473 |
| site_id | AC8 |
| Number of Residues | 4 |
| Details | binding site for residue EDO B 606 |
| Chain | Residue |
| B | LEU524 |
| B | HIS530 |
| B | ARG535 |
| C | GLU525 |
| site_id | AC9 |
| Number of Residues | 3 |
| Details | binding site for residue EDO B 607 |
| Chain | Residue |
| B | LYS428 |
| B | SER432 |
| B | LEU455 |
| site_id | AD1 |
| Number of Residues | 3 |
| Details | binding site for residue EDO C 602 |
| Chain | Residue |
| C | SER513 |
| C | HIS547 |
| C | SER548 |
| site_id | AD2 |
| Number of Residues | 2 |
| Details | binding site for residue EDO C 603 |
| Chain | Residue |
| C | HIS516 |
| C | ARG517 |
| site_id | AD3 |
| Number of Residues | 2 |
| Details | binding site for residue EDO C 604 |
| Chain | Residue |
| C | TRP420 |
| C | GLU469 |
| site_id | AD4 |
| Number of Residues | 5 |
| Details | binding site for residue EDO D 601 |
| Chain | Residue |
| D | GLY425 |
| D | PHE426 |
| D | TYR429 |
| D | ARG465 |
| E | GLN437 |
| site_id | AD5 |
| Number of Residues | 8 |
| Details | binding site for residue PEG D 602 |
| Chain | Residue |
| D | ALA477 |
| D | ASN478 |
| D | TYR479 |
| D | SER480 |
| D | ASP483 |
| D | ASN486 |
| D | ALA488 |
| D | ARG499 |
| site_id | AD6 |
| Number of Residues | 2 |
| Details | binding site for residue EDO D 604 |
| Chain | Residue |
| D | ASP489 |
| D | ARG512 |
| site_id | AD7 |
| Number of Residues | 3 |
| Details | binding site for residue EDO D 605 |
| Chain | Residue |
| D | LYS428 |
| D | SER432 |
| D | LEU455 |
| site_id | AD8 |
| Number of Residues | 2 |
| Details | binding site for residue EDO D 606 |
| Chain | Residue |
| D | GLU448 |
| D | ARG463 |
| site_id | AD9 |
| Number of Residues | 5 |
| Details | binding site for residue EDO D 607 |
| Chain | Residue |
| D | GLN452 |
| D | LYS458 |
| D | ARG463 |
| E | GLU449 |
| E | ASP454 |
| site_id | AE1 |
| Number of Residues | 4 |
| Details | binding site for residue EDO D 608 |
| Chain | Residue |
| D | ARG465 |
| D | ARG468 |
| E | GLN437 |
| E | ASP439 |
| site_id | AE2 |
| Number of Residues | 7 |
| Details | binding site for residue EDO E 601 |
| Chain | Residue |
| D | GLU520 |
| D | GLY532 |
| D | ARG535 |
| E | GLN521 |
| E | GLN522 |
| E | GLU525 |
| E | ASP526 |
| site_id | AE3 |
| Number of Residues | 3 |
| Details | binding site for residue EDO F 601 |
| Chain | Residue |
| E | SER459 |
| F | GLN436 |
| F | ASP454 |
| site_id | AE4 |
| Number of Residues | 5 |
| Details | binding site for Di-peptide BME B 604 and CYS B 482 |
| Chain | Residue |
| B | TYR479 |
| B | SER480 |
| B | THR481 |
| B | ASP483 |
| B | VAL506 |
| site_id | AE5 |
| Number of Residues | 6 |
| Details | binding site for Di-peptide BME C 601 and CYS C 482 |
| Chain | Residue |
| C | TYR479 |
| C | SER480 |
| C | THR481 |
| C | ASP483 |
| C | TYR503 |
| C | VAL506 |
| site_id | AE6 |
| Number of Residues | 7 |
| Details | binding site for Di-peptide BME D 603 and CYS D 482 |
| Chain | Residue |
| D | THR481 |
| D | ASP483 |
| D | VAL506 |
| D | SER507 |
| C | ARG497 |
| D | TYR479 |
| D | SER480 |
| site_id | AE7 |
| Number of Residues | 6 |
| Details | binding site for Di-peptide BME E 602 and CYS E 482 |
| Chain | Residue |
| E | TYR479 |
| E | SER480 |
| E | THR481 |
| E | ASP483 |
| E | VAL506 |
| E | SER507 |
| site_id | AE8 |
| Number of Residues | 7 |
| Details | binding site for Di-peptide BME F 602 and CYS F 482 |
| Chain | Residue |
| F | TYR479 |
| F | SER480 |
| F | THR481 |
| F | ASP483 |
| F | TYR503 |
| F | VAL506 |
| F | SER507 |
| site_id | AE9 |
| Number of Residues | 6 |
| Details | binding site for Di-peptide BME G 601 and CYS G 482 |
| Chain | Residue |
| G | TYR479 |
| G | SER480 |
| G | THR481 |
| G | ASP483 |
| G | VAL506 |
| G | SER507 |
| site_id | AF1 |
| Number of Residues | 7 |
| Details | binding site for Di-peptide BME H 601 and CYS H 482 |
| Chain | Residue |
| H | TYR479 |
| H | SER480 |
| H | THR481 |
| H | ASP483 |
| H | ARG484 |
| H | VAL506 |
| H | SER507 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 8 |
| Details | MOD_RES: Phosphoserine => ECO:0000269|PubMed:30333228 |
| Chain | Residue | Details |
| A | SER548 | |
| B | SER548 | |
| C | SER548 | |
| D | SER548 | |
| E | SER548 | |
| F | SER548 | |
| G | SER548 | |
| H | SER548 |
