6ZFM
Structure of alpha-Cobratoxin with a peptide inhibitor
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005576 | cellular_component | extracellular region |
| A | 0030550 | molecular_function | acetylcholine receptor inhibitor activity |
| A | 0035821 | biological_process | modulation of process of another organism |
| A | 0090729 | molecular_function | toxin activity |
| A | 0099106 | molecular_function | ion channel regulator activity |
| B | 0005576 | cellular_component | extracellular region |
| B | 0030550 | molecular_function | acetylcholine receptor inhibitor activity |
| B | 0035821 | biological_process | modulation of process of another organism |
| B | 0090729 | molecular_function | toxin activity |
| B | 0099106 | molecular_function | ion channel regulator activity |
| D | 0005576 | cellular_component | extracellular region |
| D | 0030550 | molecular_function | acetylcholine receptor inhibitor activity |
| D | 0035821 | biological_process | modulation of process of another organism |
| D | 0090729 | molecular_function | toxin activity |
| D | 0099106 | molecular_function | ion channel regulator activity |
| E | 0005576 | cellular_component | extracellular region |
| E | 0030550 | molecular_function | acetylcholine receptor inhibitor activity |
| E | 0035821 | biological_process | modulation of process of another organism |
| E | 0090729 | molecular_function | toxin activity |
| E | 0099106 | molecular_function | ion channel regulator activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 7 |
| Details | binding site for residue 1PE F 102 |
| Chain | Residue |
| B | PHE29 |
| C | TYR8 |
| C | MET9 |
| E | ILE32 |
| F | TYR8 |
| F | MET9 |
| F | HOH201 |
| site_id | AC2 |
| Number of Residues | 12 |
| Details | binding site for Di-peptide QJE C 101 and TYR C 2 |
| Chain | Residue |
| B | ARG33 |
| B | GLY34 |
| B | LYS35 |
| B | ARG36 |
| B | VAL37 |
| B | PHE65 |
| C | MET3 |
| C | TRP4 |
| C | HOH203 |
| C | HOH207 |
| B | ASP27 |
| B | PHE29 |
| site_id | AC3 |
| Number of Residues | 11 |
| Details | binding site for Di-peptide QJE F 101 and TYR F 2 |
| Chain | Residue |
| E | ASP27 |
| E | PHE29 |
| E | ARG33 |
| E | GLY34 |
| E | LYS35 |
| E | ARG36 |
| E | VAL37 |
| E | PHE65 |
| F | MET3 |
| F | TRP4 |
| F | HOH203 |
Functional Information from PROSITE/UniProt
| site_id | PS00272 |
| Number of Residues | 21 |
| Details | SNAKE_TOXIN Snake toxins signature. GCaatCPtvktgvdiq.CCstD |
| Chain | Residue | Details |
| A | GLY40-ASP60 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 8 |
| Details | SITE: Binds to Torpedo AChR => ECO:0000269|PubMed:10574958 |
| Chain | Residue | Details |
| A | LYS23 | |
| A | LYS49 | |
| B | LYS23 | |
| B | LYS49 | |
| D | LYS23 | |
| D | LYS49 | |
| E | LYS23 | |
| E | LYS49 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 20 |
| Details | SITE: Binds to both neuronal alpha-7/CHRNA7 and Torpedo AChRs => ECO:0000269|PubMed:10574958, ECO:0000269|PubMed:10852927 |
| Chain | Residue | Details |
| A | TRP25 | |
| B | PHE65 | |
| D | TRP25 | |
| D | ASP27 | |
| D | PHE29 | |
| D | ARG33 | |
| D | PHE65 | |
| E | TRP25 | |
| E | ASP27 | |
| E | PHE29 | |
| E | ARG33 | |
| A | ASP27 | |
| E | PHE65 | |
| A | PHE29 | |
| A | ARG33 | |
| A | PHE65 | |
| B | TRP25 | |
| B | ASP27 | |
| B | PHE29 | |
| B | ARG33 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 8 |
| Details | SITE: Binds to alpha-7/CHRNA7 AChR => ECO:0000269|PubMed:10852927 |
| Chain | Residue | Details |
| A | ALA28 | |
| A | LYS35 | |
| B | ALA28 | |
| B | LYS35 | |
| D | ALA28 | |
| D | LYS35 | |
| E | ALA28 | |
| E | LYS35 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 4 |
| Details | SITE: Binds to both neuronal alpha-7/CHRNA7 and Torpedo AChRs, may be important for inhibition of GABA(A) receptors => ECO:0000269|PubMed:10574958, ECO:0000269|PubMed:10852927, ECO:0000305|PubMed:26221036 |
| Chain | Residue | Details |
| A | ARG36 | |
| B | ARG36 | |
| D | ARG36 | |
| E | ARG36 |
