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6ZF8

Keap1 kelch domain bound to a small molecule inhibitor of the Keap1-Nrf2 protein-protein interaction

Functional Information from GO Data
ChainGOidnamespacecontents
A0008134molecular_functiontranscription factor binding
A0016567biological_processprotein ubiquitination
A0031463cellular_componentCul3-RING ubiquitin ligase complex
Functional Information from PDB Data
site_idAC1
Number of Residues10
Detailsbinding site for residue SO4 A 701
ChainResidue
AILE435
AHOH955
AHIS437
ASER438
ASER439
AARG494
AHOH807
AHOH835
AHOH838
AHOH882

site_idAC2
Number of Residues6
Detailsbinding site for residue SO4 A 702
ChainResidue
ACYS434
AHIS436
AARG459
AARG494
AARG498
AHOH824

site_idAC3
Number of Residues3
Detailsbinding site for residue DMS A 703
ChainResidue
AARG494
AASN495
ADMS711

site_idAC4
Number of Residues7
Detailsbinding site for residue DMS A 704
ChainResidue
ATHR388
AASP389
ASER390
ASER391
AARG470
AHOH808
AHOH884

site_idAC5
Number of Residues3
Detailsbinding site for residue DMS A 705
ChainResidue
ALEU457
ATHR458
AARG459

site_idAC6
Number of Residues2
Detailsbinding site for residue DMS A 706
ChainResidue
AARG442
AARG447

site_idAC7
Number of Residues2
Detailsbinding site for residue DMS A 707
ChainResidue
AALA407
ASER408

site_idAC8
Number of Residues3
Detailsbinding site for residue DMS A 708
ChainResidue
AARG459
AARG494
AARG498

site_idAC9
Number of Residues6
Detailsbinding site for residue DMS A 709
ChainResidue
AILE421
AHIS424
ATYR426
AARG442
APRO492
AHOH979

site_idAD1
Number of Residues4
Detailsbinding site for residue DMS A 710
ChainResidue
AARG326
AHIS562
AGLN563
AHOH863

site_idAD2
Number of Residues5
Detailsbinding site for residue DMS A 711
ChainResidue
ALEU452
AVAL453
AALA454
AASN495
ADMS703

site_idAD3
Number of Residues2
Detailsbinding site for residue DMS A 712
ChainResidue
APRO361
AHIS553

site_idAD4
Number of Residues4
Detailsbinding site for residue DMS A 713
ChainResidue
ATYR525
AGLN530
ASER555
AQHZ717

site_idAD5
Number of Residues2
Detailsbinding site for residue DMS A 714
ChainResidue
AHIS451
ALEU452

site_idAD6
Number of Residues8
Detailsbinding site for residue DMS A 715
ChainResidue
AALA356
AASP357
AARG551
AHIS552
AGLU593
AHOH822
AHOH943
AHOH956

site_idAD7
Number of Residues8
Detailsbinding site for residue DMS A 716
ChainResidue
AARG380
AGLY433
AVAL539
AGLU540
AHOH801
AHOH803
AHOH957
AHOH967

site_idAD8
Number of Residues12
Detailsbinding site for residue QHZ A 717
ChainResidue
ATYR334
AASN414
AARG415
AARG483
ASER508
AGLY509
ATYR572
APHE577
ASER602
AGLY603
ADMS713
AHOH802

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues45
DetailsRepeat: {"description":"Kelch 1"}
ChainResidueDetails

site_idSWS_FT_FI2
Number of Residues50
DetailsRepeat: {"description":"Kelch 2"}
ChainResidueDetails

site_idSWS_FT_FI3
Number of Residues46
DetailsRepeat: {"description":"Kelch 3"}
ChainResidueDetails

site_idSWS_FT_FI4
Number of Residues46
DetailsRepeat: {"description":"Kelch 4"}
ChainResidueDetails

site_idSWS_FT_FI5
Number of Residues45
DetailsRepeat: {"description":"Kelch 5"}
ChainResidueDetails

site_idSWS_FT_FI6
Number of Residues46
DetailsRepeat: {"description":"Kelch 6"}
ChainResidueDetails

site_idSWS_FT_FI7
Number of Residues1
DetailsSite: {"description":"Sensor for electrophilic agents","evidences":[{"source":"PubMed","id":"20498371","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails

site_idSWS_FT_FI8
Number of Residues1
DetailsModified residue: {"description":"S-cGMP-cysteine","evidences":[{"source":"PubMed","id":"20498371","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails

243083

PDB entries from 2025-10-15

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