6ZF8

Keap1 kelch domain bound to a small molecule inhibitor of the Keap1-Nrf2 protein-protein interaction

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0008134	molecular_function	transcription factor binding
A	0016567	biological_process	protein ubiquitination
A	0031463	cellular_component	Cul3-RING ubiquitin ligase complex

Functional Information from PDB Data

site_id	AC1
Number of Residues	10
Details	binding site for residue SO4 A 701

Chain	Residue
A	ILE435
A	HOH955
A	HIS437
A	SER438
A	SER439
A	ARG494
A	HOH807
A	HOH835
A	HOH838
A	HOH882

---

site_id	AC2
Number of Residues	6
Details	binding site for residue SO4 A 702

Chain	Residue
A	CYS434
A	HIS436
A	ARG459
A	ARG494
A	ARG498
A	HOH824

---

site_id	AC3
Number of Residues	3
Details	binding site for residue DMS A 703

Chain	Residue
A	ARG494
A	ASN495
A	DMS711

---

site_id	AC4
Number of Residues	7
Details	binding site for residue DMS A 704

Chain	Residue
A	THR388
A	ASP389
A	SER390
A	SER391
A	ARG470
A	HOH808
A	HOH884

---

site_id	AC5
Number of Residues	3
Details	binding site for residue DMS A 705

Chain	Residue
A	LEU457
A	THR458
A	ARG459

---

site_id	AC6
Number of Residues	2
Details	binding site for residue DMS A 706

Chain	Residue
A	ARG442
A	ARG447

---

site_id	AC7
Number of Residues	2
Details	binding site for residue DMS A 707

Chain	Residue
A	ALA407
A	SER408

---

site_id	AC8
Number of Residues	3
Details	binding site for residue DMS A 708

Chain	Residue
A	ARG459
A	ARG494
A	ARG498

---

site_id	AC9
Number of Residues	6
Details	binding site for residue DMS A 709

Chain	Residue
A	ILE421
A	HIS424
A	TYR426
A	ARG442
A	PRO492
A	HOH979

---

site_id	AD1
Number of Residues	4
Details	binding site for residue DMS A 710

Chain	Residue
A	ARG326
A	HIS562
A	GLN563
A	HOH863

---

site_id	AD2
Number of Residues	5
Details	binding site for residue DMS A 711

Chain	Residue
A	LEU452
A	VAL453
A	ALA454
A	ASN495
A	DMS703

---

site_id	AD3
Number of Residues	2
Details	binding site for residue DMS A 712

Chain	Residue
A	PRO361
A	HIS553

---

site_id	AD4
Number of Residues	4
Details	binding site for residue DMS A 713

Chain	Residue
A	TYR525
A	GLN530
A	SER555
A	QHZ717

---

site_id	AD5
Number of Residues	2
Details	binding site for residue DMS A 714

Chain	Residue
A	HIS451
A	LEU452

---

site_id	AD6
Number of Residues	8
Details	binding site for residue DMS A 715

Chain	Residue
A	ALA356
A	ASP357
A	ARG551
A	HIS552
A	GLU593
A	HOH822
A	HOH943
A	HOH956

---

site_id	AD7
Number of Residues	8
Details	binding site for residue DMS A 716

Chain	Residue
A	ARG380
A	GLY433
A	VAL539
A	GLU540
A	HOH801
A	HOH803
A	HOH957
A	HOH967

---

site_id	AD8
Number of Residues	12
Details	binding site for residue QHZ A 717

Chain	Residue
A	TYR334
A	ASN414
A	ARG415
A	ARG483
A	SER508
A	GLY509
A	TYR572
A	PHE577
A	SER602
A	GLY603
A	DMS713
A	HOH802

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	45
Details	Repeat: {"description":"Kelch 1"}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	50
Details	Repeat: {"description":"Kelch 2"}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	46
Details	Repeat: {"description":"Kelch 3"}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	46
Details	Repeat: {"description":"Kelch 4"}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	45
Details	Repeat: {"description":"Kelch 5"}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	46
Details	Repeat: {"description":"Kelch 6"}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	1
Details	Site: {"description":"Sensor for electrophilic agents","evidences":[{"source":"PubMed","id":"20498371","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	1
Details	Modified residue: {"description":"S-cGMP-cysteine","evidences":[{"source":"PubMed","id":"20498371","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---